Two functionally distinct forms of NKX2.1 protein are expressed in the pulmonary epithelium

Biochemical and Biophysical Research Communications

Volumn 270, Issue 2, 2000, Pages 462-468

  Li, Changgong ^a   Cai, Jiaxin ^a   Pan, Quping ^a   Minoo, Parviz ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; EMBRYO DEVELOPMENT; EXON; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; THYROID GLAND;

MAMMALIA;

EID: 0034643263     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2443     Document Type: Article

References (16)

1. Kimura S., Hara Y., Pineau T., Fernardenz-Salguero P., Fox C. H., Ward J. M., Gonzalez F. J. The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 10:1996;60-69.
2. Minoo P., Su G., Drum H., Bringas P., Kimura S. Defects in tracheoesophageal and lung morphogenesis in Nkx2.1 (-/-) mouse embryos. Dev. Biol. 209:1999;60-71.
3. Guazzi S., Price M., De Felice M., Damante G., Mattei M-G., Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding Specificity. EMBO J. 9:1990;3631-3639.
4. Hamdan H., Liu H., Li C., Jones C., Lee M., deLemos R., Minoo P. Structure of the human Nkx2.1 gene. Biochem. et Biophys. Acta. 1396:1998;336-348.
5. Kelly S. E., Bachurski C. J., Burhans M. S., Glasser S. W. Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1. J. Biol. Chem. 271:1996;6881-6888.
6. Ramirez M. I., Richi A. K., Cao Y. X., Williams M. C. TGT3, thyroid transcription factor I, and Sp1 elements regulate transcriptional activity of the 1.3-kilobase pair promoter of T1alpha, a lung alveolar type I cell gene. J. Biol. Chem. 272:1997;26285-26294.
7. Chun Y. S., Saji M., Zeiger M. A. Overexpression of TTF-1 and PAX-8 restores thyroglobulin gene promoter activity in ARO and WRO cell lines. Surgery. 124:1998;1100-1105.
8. Ros P., Rossi D. L., Acebron A., Santisteban P. Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Biochimie. 81:1999;389-396.
9. Bohinski R. J., DiLauro R., Whitsett J. A. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 14:1994;5671-5681.
10. Wikenheiser K. A., Vorbroker D. K., Rice W. R., Clark J. C., Bachurski C. J., Oie H. K., Whitsett J. A. Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc. Natl. Acad. Sci. USA. 90:1993;11029-11033.
11. Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 1987;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
12. Zannini M., Acebron A., DeFelice M., Arnone M. I., Martin-Perez J., Santisteban P., DiLauro R. Mapping and functional role of phosphorylation sites in the Thyroid Transcription Factor-1 (TTF-1). J. Biol. Chem. 271:1996;2249-2254.
13. Yan C., Whitsett A. Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of Thyroid Transcription Factor 1. J. Biol. Chem. 272:1997;17327-17332.
14. Ikeda K., Clark J. C., Shaw-White J. R., Stahlman M. T., Boutell C. J., Whitsett J. A. Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells. J. Biol. Chem. 270:1995;8108-8114.
15. Reecy J. M., Li X., Yamada M., DeMayo F. J., Newman C. S., Harvey R. P., Schwartz R. J. Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5. Development. 126:1999;839-849.
16. Li C., Ling X., Yuan B., Minoo P. A novel DNA element mediates transcription of Nkx2.1 by Sp1 and Sp3 in pulmonary epithelial cells. Biochim. Biophys. Acta. 1490:2000;213-224.