Increased TNF-α and PGI2, but not NO release from macrophages in 18-month-old rats

Mechanisms of Ageing and Development

Volumn 114, Issue 2, 2000, Pages 79-88

  Tang, Yueming ^a   Di Pietro, Luisa ^b   Feng, Yan ^a   Wang, Xian ^a  

^a Third Teaching Hospital   (China)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aging; Macrophage; Nitric oxide; Prostaglandin; TNF

Indexed keywords

MESSENGER RNA; NITRIC OXIDE; PROSTACYCLIN; TUMOR NECROSIS FACTOR ALPHA;

AGE; AGED; AGING; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; MALE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; EPOPROSTENOL; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; NITRIC OXIDE; RATS; RATS, WISTAR; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034642964     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(00)00090-7     Document Type: Article

References (29)

1. Alvarez E., Machado A., Sobrino F., Santa-Macia C. Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages. Cell. Immunol. 169:1996;152-155.
2. Bradley S.F., Vibhagool A., Kunkel S.L., Kauffman C.A. Monokine secretion in aging and protein malnutrition. J. Leuk. Biol. 45:1989;510-514.
3. Chen Y., Bradley S.F. Aging and eliciting agents: effect on murine peritoneal macrophage monokine activity. Exp. Gerontol. 28:1993;145-159.
4. Chen L., Pace J., Russell S.W., Morrison D.C. Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice. Infect. Immun. 64:1996;4288-4298.
5. Chorinchath B.B., Kong L.Y., Mao L., McCallum R.E. Age-associated differences in TNF-α and nitric oxide production in endotoxic mice. J. Immunol. 156:1996;1525-1530.
6. Davila D.R., Edwards C.K., Arkins S., Simon J., Kelley K.W. Interferon-γ induced priming for secretion of superoxide anion and tumor necrosis factor-α decline in macrophages from aged rats. FASEB J. 4:1990;2906-2911.
7. Deakin A.M., Payne A.N., Whittle B.J.R., Moncada S. The modulation of IL-6 and TNF-α release by nitric oxide following stimulation of J774 cells with LPS and IFN-γ Cytokine. 5:1995;408-416.
8. Dong Y.L., Hernoon D.N., Yan T.Z., Waymack J.P. Blockade of prostaglandin augments macrophage and neutrophil tumor necrosis factor synthesis in burn injury. J. Surg. Res. 54:1993;480-485.
9. Eigler A., Moeller J., Endres S. Exogenous and endogenous nitric oxide attenuates tumor necrosis factor synthesis in the murine macrophage cell line RAW 264.7. J. Immunol. 154:1995;4048-4054.
10. Fagiolo U., Cossarizza A., Scala E. et al. Increase cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23:1993;2375-2378.
11. Feng Y., Tang Y., Guo J., Wang X. Inhibition of LPS-induced TNF-α production by calcitonin gene-related peptide (CGRP) in cultured mouse peritoneal macrophages. Life Sci. 61:1997;PL281-PL287.
12. Foster K.D., Conn C.A., Kluger N.J. Fever, tumor necrosis factor and interleukin-6 in young, mature, and aged Fischer 344 rats. Am. J. Physiol. 262:1992;R211-R215.
13. Galanos C., Freudenberg M.A. Tumor necrosis factor mediates endotoxin shock: protective effects of antibodies and cortisone. Bonavida B, Granger G Tumor necrosis factor: Structure, Mechanism of Action, Role in Disease and Therapy. 1990;187-193 Karger, Basel.
14. Green L.C., Wagner D.A., Glogwski J. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem. 126:1982;131-138.
15. Hayek M.G., Mura C., Wu D. et al. Enhanced expression of inducible cyclooxygenase with age in murine macrophages. J. Immunol. 159:1997;2445-2451.
16. Hyde S., McCallum R.E. Lipopolysaccharide-tumor necrosis factor-α glucocorticoid interactions during cecal ligation and puncture-induced sepsis in mature versus senescent mice. Infect. Immun. 60:1992;976-982.
17. Mayoral J.L., Schweich C.J., Dunn D.L. Decreased tumor necrosis factor production during the initial stages of infection correlates with survival during murine Gram-negative sepsis. Arch. Surg. 125:1990;24-28.
18. Mooradian A.D., Reed R.L., Scuderi P. Serum levels of tumor necrosis factor alpha, interleukin-1 alpha and beta in healthy elderly subjects. Age. 14:1991;61-64.
19. Morrison D.C., Chen L.C., Pace J.L. Altered regulation of nitric oxide production in vitro by macrophages from senescent mice. J. Leuk. Biol. 54:1993;575-580.
20. Mysliwska J., Bryl E., Foerster J., Mysliwske A. The upregulation of TNF-α production is not a generalised phenomenon in the elderly between their sixth and seventh decades of life. Mech. Ageing Dev. 107:1999;1-14.
21. Pierre V. The pathphysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:1992;411-452.
22. Riancho J.A., Zarrabeitia M.T., Amado J.A., Olmos J.M., Mac'ias J.G. Age-related difference in cytokine secretion. Gerontology. 40:1994;8-12.
23. Strassmann G., Patil-koota V., Finkelman F., Fong M., Kambayashi T. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med. 180:1994;2365-2370.
24. Tang Y., Han C., Wang X. Role of nitric oxide and prostaglandins in the potentiating effects of calcitonin gene-related peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages. Immunology. 96:1999;171-175.
25. Tang Y., Han C., Fiscus R.R., Wang X. Increase of calcitonin gene-related peptide (CGRP) release and mRNA levels in endotoxic rats. Shock. 7:1997;225-229.
26. Thonassen M.J., Buhrow L.T., Connors M.J., Kaneko F.T., Erzurum S.C., Kavuru M.S. Nitric oxide inhibits inflammatory cytokine production by human alveolar macrophages. Am. J. Respir. Cell. Mol. Biol. 17:1997;279-283.
27. Wu D., Mura C., Beharka A.A. et al. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. Am. J. Physiol. 275:1998;C661-C668.
28. Zhang X., Morrison D.C. Lipopolysaccharide-induced selective priming effects on tumor necrosis factor α and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 177:1993a;511-516.
29. Zhang X., Morrison D.C. Pertussis toxin-sensitive factor differentially regulates lipopolysaccharide-induced tumor necrosis factor α and nitric oxide production in mouse peritoneal macrophages. J. Immunol. 150:1993b;1011-1018.