Trifluoromethyl ketones derived from squalene: Inhibition of the cholesterol biosynthesis in HepG2 cells

Tetrahedron Letters

Volumn 41, Issue 33, 2000, Pages 6367-6370

  Benayoud, Farid ^a   Abouabdellah, Ahmed ^a   Richard, Cyrille ^a   Bonnet Delpon, Danièle ^a   Bégué, Jean Pierre ^a   Levasseur, Danielle ^b   Boutaud, Olivier ^b   Schuber, Francis ^b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FLUORINE DERIVATIVE; FLUOROFORM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETONE DERIVATIVE; OXYSTEROL; SQUALENE;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL SYNTHESIS; ENZYME INHIBITION; ENZYME REPRESSION;

EID: 0034641444     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)01066-2     Document Type: Article

References (30)

1. 14C]acetate incorporation into non-saponifiable sterols in HepG2 cells and HMG-CoA reductase assays were performed as described previously
2. Other fluoro epoxysqaalenes exhibited poor inhibitory activity on OSC