Cell vacuolation induced by the VacA cytotoxin of Helicobacter pylori is regulated by the Rac1 GTPase

Journal of Biological Chemistry

Volumn 275, Issue 19, 2000, Pages 14009-14012

  Hotchin, Neil A ^a   Cover, Timothy L ^b   Akhtar, Nasreen ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DUODENUM ULCER; HELICOBACTER PYLORI; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; CYTOTOXINS; DOGS; HELICOBACTER PYLORI; RAC1 GTP-BINDING PROTEIN; VACUOLES;

EID: 0034640406     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000153200     Document Type: Article

References (33)

1. Cover, T. L., and Blaser, M. J. (1992) Annu. Rev. Med. 43, 135-145
2. Cover, T. L. (1996) Mol. Microbiol. 20, 241-246
3. Molinari, M., Galli, C., Norais, N., Telford, J. L., Rappuoli, R., Luzio, J. P., and Montecucco, C. (1997) J. Biol. Chem. 272, 25339-25344
4. Satin, B., Norais, N., Telford, J., Rappuoli, R., Murgia, M., Montecucco, C., and Papini, E. (1997) J. Biol. Chem. 272, 25022-25028
5. Czajkowsky, D. M., Iwamoto, H., Cover, T. L., and Shao, Z. (1999) Proc. Natl. Acad. Set. U. S. A. 96, 2001-2006
6. Papini, E., Satin, B., Bucci, C., de Bernard, M., Telford, J. L., Manetti, R., Rappuoli, R., Zerial, M., and Montecucco, C. (1997) EMBO J. 16, 15-24
7. Iwamoto, H., Czajkowsky, D. M., Cover, T. L., Szabo, G., and Shao, Z. (1999) FEBS Lett. 450, 101-104
8. Tombola, F., Carlesso, C., Szabo, I., de Bernard, M., Reyrat, J. M., Telford, J. L., Rappuoli, R., Montecucco, C., Papini, E., and Zoratti, M. (1999) Biophys. J. 76, 1401-1409
9. Hall, A. (1998) Science 279, 509-514
10. Bretscher, M. S., and Aguado-Velasco, C. (1998) Curr. Biol. 8, 721-724
11. Ellis, S., and Mellor, H. (2000) Trends Cell Biol. 10, 85-88
12. Gampel, A., Parker, P. J., and Mellor, H. (1999) Curr. Biol. 9, 955-958
13. Lamaze, C., Chuang, T. H., Terlecky, L. J., Bokoch, G. M., and Schmid, S. L. (1996) Nature 382, 177-179
14. Murphy, C., Saffrich, R., Grummt, M., Gournier, H., Rybin, V., Rubino, M., Auvinen, P., Lutcke, A., Parton, R. G., and Zerial, M. (1996) Nature 384, 427-432
15. Mellor, H., Flynn, P., Nobes, C. D., Hall, A., and Parker, P. J. (1998) J. Biol. Chem. 273, 4811-4814
16. Mounier, J., Laurent, V., Hall, A., Fort, P., Carlier, M. F., Sansonetti, P. J., and Egile, C. (1999) J. Cell Sci. 112, 2069-2080
17. Adam, T., Giry, M., Boquet, P., and Sansonetti, P. (1996) EMBO J. 15, 3315-3321
18. Rheinwald, J. G., and Green, H. (1975) Cell 6, 331-343
19. Hotchin, N. A., and Watt, F. M. (1992) J. Biol. Chem. 267, 14852-14838
20. Jou, T. S., and Nelson, W. J. (1998) J. Cell Biol. 142, 85-100
21. Cover, T. L., Hanson, P. I., and Heuser, J. E. (1997) J. Cell Biol. 138, 759-769
22. Akhtar, N., Hudson, K. R., and Hotchin, N. A. (2000) Cell Adh. Comm., in press
23. Nobes, C. D., and Hall, A. (1995) Cell 81, 53-62
24. Cover, T. L., Puryear, W., Perez-Perez, G. I., and Blaser, M. J. (1991) Infect. Immun. 59, 1254-1270
25. Landegren, U. (1984) J. Immunol. Methods 67, 379-388
26. de Bernard, M., Moschioni, M., Papini, E., Telford, J., Rappuoli, R., and Montecucco, C. (1998) Toxicol. Lett. 99, 109-115
27. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992) Cell 70, 401-410
28. Robertson, D., Paterson, H. F., Adamson, P., Hall, A., and Monaghan, P. (1995) J. Histochem. Cytochem. 43, 471-480
29. de Bernard, M., Arico, B., Papini, E., Rizzuto, R., Grandi, G., Rappuoli, R., and Montecucco, C. (1997) Mol. Microbiol. 26, 665-674
30. de Bernard, M., Moschioni, M., Papini, E., Telford, J. L., Rappuoli, R., and Montecucco, C. (1998) FEBS Lett. 436, 218-222
31. Nobes, C. D., Hawkins, P., Stephens, L., and Hall, A. (1995) J. Cell Sci. 108, 225-233
32. Palovuori, R., Perttu, A., Yan, Y., Karttunen, R., Eskelinen, S., and Karttunen, T. J. (2000) Biochem. Biophys. Res. Commun. 269, 247-253
33. Segal, E. D., Falkow, S., and Tompkins, L. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1259-1264