A differential role of CREB phosphorylation in cAMP-inducible gene expression in the rat pineal

Brain Research

Volumn 864, Issue 2, 2000, Pages 270-280

  Spessert, Rainer ^a   Rapp, Maria ^a   Jastrow, Holger ^a   Karabul, Nesrin ^a   Blum, Frank ^a   Vollrath, Lutz ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Arylalkylamine N acetyltransferase; cAMP; cAMP response element binding protein (CREB); Fos related antigen 2 (Fra 2); Inducible cAMP early repressor (ICER); JunB; Okadaic acid; Rat pineal

Indexed keywords

ARALKYLAMINE ACETYLTRANSFERASE; BUCLADESINE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; OKADAIC ACID; TRANSCRIPTION FACTOR;

ARTICLE; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; IMMUNOBLOTTING; IMMUNOREACTIVITY; PINEAL BODY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; BLOTTING, WESTERN; BUCLADESINE; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FOS-RELATED ANTIGEN-2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; NERVE TISSUE PROTEINS; OKADAIC ACID; PHOSPHORYLATION; PINEAL GLAND; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034640193     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02185-5     Document Type: Article

References (33)

1. R. Baler, D.C. Klein, Circadian expression of transcription factor Fra-2 in the rat pineal gland, J. Biol. Chem. 45 (1995) 27319-27325.
2. R. Baler, S. Covington, D.C. Klein, The rat arylalkylamine N-acetyltransferase gene promotor. cAMP activation via a cAMP-responsive element-CCAAT complex, J. Biol. Chem. 272 (1997) 6979-6985.
3. J. Borjigin, M.M. Wang, S.H. Snyder, Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland, Nature 371 (1995) 783-785.
4. D.A. Carter, A daily rhythm of activator protein-1 activity in the rat pineal is dependent upon trans-synaptic induction of JunB, Neuro-science 62 (1994) 1267-1278.
5. S.L. Coon, PH. Roseboom, R. Baler, J.L. Weller, M.A.A. Namboodiri, E.V. Koonin, D.C. Klein, Pineal serotonin N-acetyltransferase: Expression cloning and molecular analysis, Science 270 (1995) 1681-1683.
6. T. Deguchi, J. Axelrod, Sensitive assay of serotonin N-acetyltransferase activity in rat pineal, Anal. Biochem. 50 (1972) 174-179.
7. V.C. Foletta, M.H. Sonobe, T. Suzuki, T. Endo, H. Iba, D.R. Cohen, Cloning and characterization of the mouse fra-2 gene, Oncogene 9 (1994) 3305-3311.
8. N.S. Foulkes, J. Borjigin, S.H. Snyder, P. Sassone-Corsi, Transcriptional control of circadian hormone synthesis via the CREM feedback loop, Proc. Natl. Acad. Sci. USA 93 (1996) 14140-14145.
9. N.S. Foulkes, G. Duval, P. Sassone-Corsi, Adaptive inducibility of CREM as transcriptional memory of circadian rhythms, Nature 381 (1996) 83-85.
10. N.S. Foulkes, D. Whitmore, P Sassone-Corsi, Rhythmic transcription: The molecular basis of circadian melatonin synthesis, Biol. Cell 89 (1997) 487-494.
11. M. Hagiwara, A. Alberts, P. Brindle, J. Meinkoth, J. Feramisco, T. Deng, M. Karin, S. Shenolikar, M. Montminy, M., Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB, Cell 70 (1992) 105-113.
12. T.A.J. Haystead, A.T.R. Sim, D. Carling, R.C. Honnor, Y. Tsukitani, P. Cohen, D.G. Hardie, Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism, Nature 337 (1989) 78-81.
13. T. Herdegen, J.D. Leah, Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by JunB, Fos and Krox, and CREB/ATF proteins, Brain Res. Rev. 28 (1998) 370-490.
14. A.B. Hickman, D.C. Klein, F. Dyda, Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 Å resolution suggests a catalytic mechanism, Mol. Cell 3 (1999) 23-32.
15. A.K. Ho, C.L. Chik, Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes, Am. J. Physiol. 268 (1995) 458-466.
16. H. Ishihara, B.L. Martin, D.L. Brautigan, H. Karaki, H. Ozaki, Y. Kato, N. Fusetani, S. Watabe, K. Hashimotot, D. Uemura, D.J. Hartshorne, Calyculin A and okadic acid: inhibitors of protein phosphatase activity, Biochem. Biophys. Res. Commun. 159 (1989) 871-877.
17. Z. Kawakami, I. Kitibayashi, T. Matsuoka, G. Gachelin, K. Yokoyama, Conserved structural motifs among mammalian JunB genes, Nucleic Acids Res. 20 (1992) 914.
18. D.C. Klein, R.Y Moore, Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by retinohypothalamic tract and the suprachiasmatic nucleus, Brain Res. 174 (1979) 245-262.
19. D.C. Klein, S.L. Coon, P.H. Roseboom, J.L. Weller, M. Bernard, J.A. Gastel, M. Zatz, P.M. Iuvone, I.R. Rodriguez, V. Begay, J. Falcon, G.M. Cahill, V.M. Cassone, R. Baler, The melatonin rhythm-generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the rat pineal gland, Rec. Prog. Horm. Res. 52 (1997) 307-358.
20. H.-W. Korf, C. Schomerus, J.H. Stehle, The pineal organ: Its hormone melatonin, and the photoneuroendocrine system, Adv. Anat. Embryol. Cell Biol. 146 (1998) 1-100.
21. U.K. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-688.
22. E. Maronde, C. Schomerus, J.H. Stehle, H.-W. Korf, Control of CREB phosphorylation and its role for induction of melatonin synthesis in rat pinealocytes, Biol. Cell 89 (1997) 505-511.
23. E. Maronde, M. Pfeffer, J. Olcese, C.A. Molina, F. Schlotter, F. Dehghani, H.-W. Korf, J.H. Stehle, Transcription factors in neuroendocrine regulation: Rhythmic changes in pCREB and ICER levels frame melatonin synthesis, J. Neurosci. 19 (1999) 3326-3336.
24. C.A. Molina, N.S. Foulkes, E. Lalli, P. Sassone-Corsi, Inducibility and negative autoregulation of CREM: an alternative promotor directs the expression of ICER, an early response repressor, Cell 93 (1993) 875-886.
25. K. Nakajima, T. Kusafuka, T. Takeda, Y. Fujitani, K. Nakae, T. Hirano, Identification of a novel interleucin-6 response element containing an ets-binding site and a CRE-like site in the junB promotor, Mol. Cell. Biol. 13 (1993) 3027-3041.
26. J.E. Reusch, P. Hsieh, D. Klemm, J. Hoeffler, B. Draznin, Insulin inhibits dephosphorylation of adenosine 3′,5′-monophosphate response element-binding protein/activating transcription factor-1: effect on nuclear phosphoserine phosphatase-2a, Endocrinology 135 (1994) 2418-2422.
27. P.H. Roseboom, D.C. Klein, Norepinephrine stimulation of pineal CREB phosphorylation: primary role of a β-adrenergic-cyclic AMP mechanism, Mol. Pharmacol. 47 (1995) 439-449.
28. P.H. Roseboom, S.L. Coon, R. Baler, S.K. McCune, J.L. Weller, D.C. Klein, Melatonin synthesis: Analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland, Endocrinology 137 (1996) 3033-3044.
29. C. Schomerus, E. Maronde, E. Laedtke, H.-W. Korf, Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) induce phosphorylation of the transcription factor CREB in subpopulations of rat pinealocytes: immunocytochemical and immunochemical evidence, Cell Tissue Res. 286 (1996) 305-313.
30. J.H. Stehle, N.S. Foulkes, C.A. Molina, V. Simmonneaux, P. Pevet, P. Sassone-Corsi, Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the rat pineal gland, Nature 365 (1993) 314-320.
31. T. Uz, H. Manev, Orcadian expression of pineal 5-lipoxygenase mRNA, NeuroReport 9 (1998) 783-786.
32. B.E. Wadzinski, W.H. Wheat, S. Jaspers, L.F. Peruski Jr., R.L. Lickteig, O.L. Johnson, D.J. Klemm, Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation, Mol. Cell Biol. 13 (1993) 2822-2834.
33. T. Yoshida, T. Suzuki, H. Sato, H. Nishina, H. Iba, Analysis of fra-2 gene expression, Nucleic Acids Res. 21 (1993) 2715-2721.