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1
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0029915494
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(a) For some examples, see:
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(a) For some examples, see: Chen, C.; Dagnino Jr., R.; De Souza, E. B.; Grigoriadis, D. E.; Huang, C. Q.; Kim, K.-I.; Liu, Z.; Moran, T.; Webb, T. R.; Whitten, J. P.; Xie, Y. F.; McCarthy, J. R. J. Med. Chem. 1996, 39, 4358-4360.
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Chen, C.1
Dagnino R., Jr.2
De Souza, E.B.3
Grigoriadis, D.E.4
Huang, C.Q.5
Kim, K.-I.6
Liu, Z.7
Moran, T.8
Webb, T.R.9
Whitten, J.P.10
Xie, Y.F.11
McCarthy, J.R.12
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2
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0023943817
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(b) and references cited therein
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(b) Maggiali, C.; Morini, G.; Mossini, F.; Morini, G.; Barocelli, E.; Impicciatore, M. Farmaco, Ed. Sci. 1987, 43, 277-291 and references cited therein.
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Maggiali, C.1
Morini, G.2
Mossini, F.3
Morini, G.4
Barocelli, E.5
Impicciatore, M.6
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3
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0033529014
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(c)
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(c) Williams, M.; Kowaluk, E. A.; Arneric, S. P. J. Med. Chem. 1999, 42, 1481-1500.
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Williams, M.1
Kowaluk, E.A.2
Arneric, S.P.3
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4
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0031694835
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(d)
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(d) Ban, M.; Taguchi, H.; Katsushima, T.; Aoki, S.; Watanabe, A. Bioorg. Med. Chem. 1998, 6, 1057-1068.
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Bioorg. Med. Chem.
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Ban, M.1
Taguchi, H.2
Katsushima, T.3
Aoki, S.4
Watanabe, A.5
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5
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0030956592
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(e)
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(e) Drugs Fut. 1997, 22, 208-210.
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(E) Drugs Fut.
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6
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0026652620
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(a) See, for example:
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(a) See, for example: Taylor, E. C.; Gillespie, P.; Patel, M. J. Org. Chem. 1992, 57, 3218-3225.
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Taylor, E.C.1
Gillespie, P.2
Patel, M.3
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8
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0008594585
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(c)
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(c) Boldyrev, I. V.; Vladimirtsev, I. F.; Romanenko, E. A.; Korzhenevskaya, N. G.; Titov, E. V.; Cherkasov, V. M. Chem. Heterocycl. Compd. (Engl. Transl.) 1977, 13, 1006-1009.
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Boldyrev, I.V.1
Vladimirtsev, I.F.2
Romanenko, E.A.3
Korzhenevskaya, N.G.4
Titov, E.V.5
Cherkasov, V.M.6
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9
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0003000662
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(a) and references cited therein. Interestingly, the reaction of 2,4,6-trichloropyrimidine with guanidine has been reported to produce regioselectively 2-guanidino-4,6-dichloropyrimidine
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(a) Vorbruggen, H. Adv. Heterocycl. Chem. 1990, 49, 117-192 and references cited therein. Interestingly, the reaction of 2,4,6-trichloropyrimidine with guanidine has been reported to produce regioselectively 2-guanidino-4,6-dichloropyrimidine:
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(1990)
Adv. Heterocycl. Chem.
, vol.49
, pp. 117-192
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Vorbruggen, H.1
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11
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21844497570
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(c) and references cited therein
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(c) Zawadzki, H.; Penkowski, M. Polish J. Chem. 1995, 69, 1409-1416 and references cited therein.
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Polish J. Chem.
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Zawadzki, H.1
Penkowski, M.2
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12
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84945096445
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(a)
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(a) Gabriel, S. Chem. Ber. 1901, 34, 3362-3366.
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(1901)
Chem. Ber.
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, pp. 3362-3366
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Gabriel, S.1
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13
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84943952094
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(b)
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(b) Büttner, E. Chem. Ber. 1903, 36, 2227-2235.
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(1903)
Chem. Ber.
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, pp. 2227-2235
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Büttner, E.1
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14
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0021354529
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Mossini, F.; Maggiali, C.; Morini, G.; Impicciatore, M.; Morini, G.; Molina, E. Farmaco, Ed. Sci. 1984, 39, 189-199.
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(1984)
Farmaco, Ed. Sci.
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, pp. 189-199
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Mossini, F.1
Maggiali, C.2
Morini, G.3
Impicciatore, M.4
Morini, G.5
Molina, E.6
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15
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84993899438
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Delia, T. J.; Stark, D.; Glenn, S. K. J. Heterocycl. Chem. 1995, 32, 1177-1180.
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Delia, T.J.1
Stark, D.2
Glenn, S.K.3
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16
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0021746725
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For further examples of amino-de-chlorinations of 2,4,6-pyrimidine see the references cited in Ref. 6. See also:
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For further examples of amino-de-chlorinations of 2,4,6-pyrimidine see the references cited in Ref. 6. See also: (a) D'Atri, G.; Gomarasca, P.; Resnati, G.; Tronconi, G.; Scolastico, C.; Sirtori, C. R. J. Med. Chem. 1984, 27, 1621-1629.
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D'Atri, G.1
Gomarasca, P.2
Resnati, G.3
Tronconi, G.4
Scolastico, C.5
Sirtori, C.R.6
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18
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0019076502
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Giovanninetti, G.; Garuti, L.; Cavrini, V.; Roveri, P.; Mannini Palenzona, A.; Sinibaldi, P.; Fusco, P. A. Farmaco, Ed. Sci. 1980, 35, 879-886.
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(1980)
Farmaco, Ed. Sci.
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, pp. 879-886
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Giovanninetti, G.1
Garuti, L.2
Cavrini, V.3
Roveri, P.4
Mannini Palenzona, A.5
Sinibaldi, P.6
Fusco, P.A.7
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20
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0343387729
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13C NMR, FT IR and mass spectrometry.
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13C NMR, FT IR and mass spectrometry.
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21
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0342952265
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The proton H-5 of 4-alkoxycarbonylamino-2,6-dichloropyrimidines 4 resonates at extraordinarily low fields (δ 7.8-8.3). This could be explained by an intramolecular C-H···O=C-N hydrogen bonding, which is confirmed by preliminary X-ray diffraction experiments.
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The proton H-5 of 4-alkoxycarbonylamino-2,6-dichloropyrimidines 4 resonates at extraordinarily low fields (δ 7.8-8.3). This could be explained by an intramolecular C-H···O=C-N hydrogen bonding, which is confirmed by preliminary X-ray diffraction experiments.
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22
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0343387728
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3)=-77.8.
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3)=-77.8.
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23
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0027394635
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NAr reaction of N-metalated phtalimide with an activated aromatic chloride: Zhao, W.-Y.; Liu, Y.; Huang, Z.-T. Synth. Commun. 1993, 23, 591-599.
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NAr reaction of N-metalated phtalimide with an activated aromatic chloride: Zhao, W.-Y.; Liu, Y.; Huang, Z.-T. Synth. Commun. 1993, 23, 591-599.
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