Stereocontrolled synthesis of a novel pharmacophore of the tubulin- depolymerizing marine natural product spongistatin

Tetrahedron Letters

Volumn 41, Issue 11, 2000, Pages 1699-1702

  Huang, He ^a   Mao, Chen ^a   Jan, Shyi Tai ^a   Uckun, Fatih M ^a  

^a Parker Hughes Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NATURAL PRODUCT; SPONGISTATIN 1; TUBULIN;

ARTICLE; PHARMACOPHORE; POLYMERIZATION; STEREOCHEMISTRY; STRUCTURE ANALYSIS; SYNTHESIS; X RAY ANALYSIS;

EID: 0034635788     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00054-X     Document Type: Article

References (9)

1. Pettit, G. R.; Cichacz, Z. A.; Gao, F.; Herald, C. L.; Boyd, M. R. J. Org. Chem. 1993, 58, 1302.
2. Bai, R.; Cichacz, Z. A.; Herald, C. L.; Pettit, G. R.; Hamel, E. Mol. Pharmacol. 1993, 44, 757; Bai, R.; Taylor, G. F.; Cichacz, Z. A.; Herald, C. L.; Kepler, J. A.; Pettit, G. R.; Hamel, E. Biochemistry 1995, 34, 9714.
3. Bai, R.; Cichacz, Z. A.; Herald, C. L.; Pettit, G. R.; Hamel, E. Mol. Pharmacol. 1993, 44, 757; Bai, R.; Taylor, G. F.; Cichacz, Z. A.; Herald, C. L.; Kepler, J. A.; Pettit, G. R.; Hamel, E. Biochemistry 1995, 34, 9714.
4. Nogales, E.; Whittaker, M.; Milligan, R. A.; Downing, K. H. Cell 1999, 96, 79; Nogales, E.; Wolf, S. G.; Downing, K. H. Nature 1998, 391, 199.
5. Nogales, E.; Whittaker, M.; Milligan, R. A.; Downing, K. H. Cell 1999, 96, 79; Nogales, E.; Wolf, S. G.; Downing, K. H. Nature 1998, 391, 199.
6. Mao, C.; Huang, H.; Jan, S.-T.; Navara, C.; Narla, R. K.; Uckun, F. M. Design and Synthesis of Novel Functional Analogs of Spongistatin as Anti-Cancer Agents. Proceedings of the American Association for Cancer Research (AACR 90th Annual Meeting), Vol. 40; Pharmacology and Experimental Therapeutics 36 - Novel Agents and Mechanisms of Action; Abstract #4108; p. 623, Philadelphia, PA; April 10-14, 1999.
7. Cohen, T.; Jeong, I.-H.; Mudryk, B.; Bhupathy, M.; Awad, M. M. A. J. Org. Chem. 1990, 55, 1528.
8. 3).
9. Uckun, F. M.; Mao, C.; Jan, S.-T. Synthetic spiroketal pyrans (SPIKET-P) as a novel class of tubulin-depolymerizing anti-cancer agents. AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Abstract #269; Washington, DC; November 16-19, 1999.