Characterization of a diltiazem-lambda carrageenan complex

International Journal of Pharmaceutics

Volumn 200, Issue 2, 2000, Pages 207-216

  Bonferoni, M C ^a   Rossi, S ^a   Ferrari, F ^a   Bettinetti, G P ^a   Caramella, C ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Controlled release matrix tablets; Dialysis equilibria; Diltiazem HCl; Drug polymer complex; Lambda carrageenan

Indexed keywords

CALCIUM ANTAGONIST; CARRAGEENAN; DILTIAZEM; POLYMER;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED RELEASE FORMULATION; DRUG RELEASE; IONIC STRENGTH; MATRIX TABLET; PRIORITY JOURNAL; X RAY ANALYSIS;

CALCIUM CHANNEL BLOCKERS; CALORIMETRY, DIFFERENTIAL SCANNING; CARRAGEENAN; DELAYED-ACTION PREPARATIONS; DIALYSIS; DILTIAZEM; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; SOLUBILITY; WATER;

EID: 0034630970     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00389-6     Document Type: Article

References (15)

1. Bonferoni M.C., Rossi S., Tamayo M., Pedraz J.L., Dominguez Gil A., Caramella C. On the employment of λ carrageenan in a matrix system. I: sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum. J. Control. Rel. 26:1993;119-127.
2. Bonferoni M.C., Rossi S., Tamayo M., Pedraz J.L., Dominguez Gil A., Caramella C. On the employment of λ carrageenan in a matrix system. II: λ carrageenan and hydroxypropylmethylcellulose mixtures. J. Control. Rel. 30:1994;175-182.
3. Bonferoni M.C., Rossi S., Ferrari F., Bertoni M., Sinistri R., Caramella C. Characterization of three hydroxypropylmethylcellulose substitution types: rheological properties and dissolution behaviour. Eur. J. Pharm. Biopharm. 41:1995;242-246.
4. Bonferoni M.C., Rossi S., Ferrari F., Bertoni M., Bolhuis G.K., Caramella C. On the employment of λ carrageenan in a matrix system. III: optimization of a λ carrageenan -HPMC hydrophilic matrix. J. Control. Rel. 51:1998;231-239.
5. Bonferoni M.C., Caramella C., 1998b. Complex between carrageenan and a water-soluble drug, having a specific granulometry and relative controlled release pharmaceutical compositions. Patent Application PCT/EP98/06864.
6. Bubnis W.A., O'Hare K., Reilly W.J., 1998. Controlled release of diphenhydramine from carrageenan complexes in tablet matrices. 25th Int. Symp. Control. Rel. Bioact. Mater.
7. Caram Lelham N., Sundelof L.O. Some aspects on characterization and properties of charged polysaccharides: an investigation of the system carrageenan/amitriptyline/water with relation to amphiphile adsorption and charge density. Int. J. Pharm. 115:1995;103-111.
8. Caram Lelham N., Sundelof L.O. The effect of hydrophobic character of drugs and helix-coil transition of k-carrageenan on the polyelectrolyte-drug interaction. Pharm. Res. 13:1996;920-925.
9. Graham H.D., Baker Y.M., Njoku-obi A.N. Complex formation between hydrocolloids and tranquilizers and hypotensive agents. J. Pharm. Sci. 52:1963;192-198.
10. Graham H.D., Baker Y.M. Interaction of antihistamines with hydrocolloids. J. Pharm. Sci. 52:1963;964-967.
11. Klotz I.M., Walker F.M., Pivan R.B. The binding of organic ions by proteins. J. Am. Chem. Soc. 68:1946;1486-1490.
12. Nath B.S., Purushotham Rao K., Gaitonde R.V. Preparation and factors influencing the diphenhydramine hydrochloride carrageenan (type I) complex. East. Pharm. 27:1984;229-232.
13. Peppas N.A. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 60:1985;110-111.
14. Takahashi Y., Nambu N., Nagai T. Interaction of several nonsteroidal antiinflammatory drugs with pectin in aqueous solution and in solid state. Chem. Pharm. Bull. 26:1978;3836-3842.
15. Takahashi Y., Nambu N., Nagai T. Interaction of phenothiazines with pectin in aqueous solution. Chem. Pharm. Bull. 29:1981;828-833.