An O-acetylated sialyl-Tn is involved in ovarian cancer-associated antigenicity

Biochemical and Biophysical Research Communications

Volumn 271, Issue 2, 2000, Pages 281-286

  Toba, Shinya ^a   Tenno, Mari ^a   Kurosaka, Akira ^a  

^a KYOTO SANGYO UNIVERSITY   (Japan)

Author keywords

Carbohydrate antigen; Monoclonal antibody; O acetylation; Ovarian cancer; Sialyl Tn

Indexed keywords

CARBOHYDRATE ANTIGEN; GALACTOSE; GLYCOCONJUGATE; MONOCLONAL ANTIBODY; MONOSACCHARIDE; MUCIN; SIALIC ACID DERIVATIVE; TIN DERIVATIVE; TUMOR ANTIGEN;

ACETYLATION; ANTIGENICITY; ARTICLE; HUMAN; OVARY CANCER; PRIORITY JOURNAL; SIALYLATION;

BOVINAE; OVIS; SIA;

EID: 0034630731     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.2618     Document Type: Article

References (32)

1. Hakomori, S. (1984) Tumor-associated carbohydrate antigens. Annu. Rev. Immunol. 2, 103-126.
2. Hakomori, S. (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids: Overview and perspectives. Cancer Res. 45, 2405-2414.
3. Sell, S. (1990) Cancer-associated carbohydrates identified by monoclonal antibodies. Hum. Pathol. 21, 1003-1019.
4. Hakomori, S. (1998) Cancer-associated glycosphingolipid anti-gens: Their structure, organization, and function. Acta Anat. 161, 79-90.
5. Kannagi, R., Nudelman, E., Levery, S. B., and Hakomori, S. (1982) A series of human erythrocyte glycosphingolipids reacting to the monoclonal antibody directed to a developmentally regulated antigen, SSEA-1. J. Biol. Chem. 257, 14865-14874.
6. Ladisch, S., Chang, F., Li, R., Cogen, P., and Johnson, D. (1997) Detection of medulloblastoma and astrocytoma-associated ganglioside GD3 in cerebrospinal fluid. Cancer Lett. 120, 71-78.
7. Hirohashi, S., Clausen, H., Yamada, T., Shimosato, Y., and Hakomori, S. (1985) Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: Its identification as Tn antigen. Proc. Natl. Acad. Sci. USA 82, 7039-7043.
8. Kurosaka, A., Fukui, S., Kitagawa, H., Nakada, H., Numata, Y., Funakoshi, I., Kawasaki, T., and Yamashina, I. (1987) Mucin-carbohydrate directed monoclonal antibody. FEBS Lett. 215, 137-139.
9. Kurosaka, A., Kitagawa, H., Fukui, S., Numata, Y., Nakada, H., Funakoshi, I., Kawasaki, T., Ogawa, T., Iijima, H., and Yamashina, I. (1988). A monoclonal antibody that recognizes a cluster of a disaccharide, NeuAcα2, 6Ga1NAc, in mucin-type glycoproteins. J. Biol. Chem. 263, 8724-8726.
10. Kjeldsen, T., Clausen, H., Hirohashi, S., Ogawa, T., Iijima, H., and Hakomori, S. (1988) Preparation and characterization of monoclonal antibodies directed to the tumor-associated O-linked sialosyl-2-6α-N-acetylgalactosaminyl (sialosyl-Tn) epitope. Cancer Res. 48, 2214-2220.
11. Longenecker, B. M., Willians, D. J., MacLean, G. D., Selvaraj, S., Suresh, M. R., and Noujaim, A. A. (1987) Monoclonal antibodies and synthetic tumor-associated glycoconjugates in the study of the expression of Thomsen-Friedenreich-like and Tn-like antigens on human cancers. J. Natl. Cancer Inst. 78, 489-496.
12. Kurosaka, A., Ikeda, K., Sakuragi, N., and Fujimoto, S. (1994) Production of monoclonal antibodies recognizing cancer-associated antigens expressed on mucin-type sugar chains. Biochem. Biophys. Res. Commun. 203, 1828-1834.
13. Tettamanti, G., and Pigman, W. (1968) Purification and characterization of bovine and ovine submaxillary mucins. Arch. Biochem. Biophys. 124, 41-50.
14. Kurosaka, A., Yano, A., Itoh, N., Kuroda, Y., Nakagawa, T., and Kawasaki, T. (1991) The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum. J. Biol. Chem. 266, 4168-4172.
15. Kuraya, N., and Hase, S. (1992) Release of O-linked sugar chains from glycoproteins with anhydrous hydrazine and pyridylamination of the sugar chains with improved reaction conditions. J. Biochem. (Tokyo) 112, 122-126.
16. Ogura, H., Furuhata, K., Sato, S., Anazawa, K., Itoh, M., and Shitori, Y. (1987) Synthesis of 9-O-acyl- and 4-O-acetyl-sialic acids. Carbohydr. Res. 167, 77-86.
17. Jourdian, G. W., Dean, L., and Roseman, S. (1971) The sialic acids. XI. A periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides. J. Biol. Chem. 246, 430-435.
18. Schauer, R. (1978) Characterization of sialic acids. Methods Enzymol. 50, 64-89.
19. Tsuji, T., and Osawa, T. (1986) Carbohydrate structures of bovine submaxillary mucin. Carbohydr. Res. 151, 391-402.
20. Traving, C., and Schauer, R. (1998) Structure, function and metabolism of sialic acids. Cell Mol. Life Sci. 54, 1330-1349.
21. Corfield, A. P., Myerscough, N., Warren, B. F., Durdey, P., Paraskeva, C., and Schauer, R. (1999). Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence. Glycoconj. J. 16, 307-317.
22. Ogata, S., Ho, I., Chen, A., Dubois, D., Maklansky, J., Singhal, A., Hakomori, S., and Itzkowitz, S. H. (1995) Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa. Cancer Res. 55, 1869-1874.
23. Jass, J. R., Allison, L. M., and Edgar, S. (1994) Monoclonal antibody TKH2 to the cancer-associated epitope sialosyl Tn shows cross-reactivity with variants of normal colorectal goblet cell mucin. Pathology 26, 418-422.
24. Mann, B., Klussmann, E., Vandamme Feldhaus, V., Iwersen, M., Hanski, M. L., Riecken, E. O., Buhr, H. J., Schauer, R., Kim, Y. S., and Hanski, C. (1997) Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases. Int. J. Cancer 72, 258-264.
25. Cheresh, D. A., Reisfeld, R. A., and Varki, A. P. (1984) O-acetylation of disialoganglioside GD3 by human melanoma cells creates a unique antigenic determinant. Science 225, 844-846.
26. Cheresh, D. A., Varki, A. P., Varki, N. M., Stallcup, W. B., Levine, J., and Reisfeld, R. A. (1984) A monoclonal antibody recognizes an O-acylated sialic acid in a human melanoma-associated ganglioside. J. Biol. Chem. 259, 7453-7459.
27. Shi, W. X., Chammas, R., Varki, N. M., Powell, L., and Varki, A. (1996) Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing. J. Biol. Chem. 271, 31526-31532.
28. Fulcheri, E., Baracchini, P., Foglia, G., Lapertosa, G., Siciliano, B., and Ragni, N. (1990) Histochemical study of mucinous ovarian cystomas of intestinal and mixed types: O-Acetylated sialomucin content in relation to biologic behavior. Tumori 76, 73-76.
29. Corfield, A. P., Wagner, S. A., O'Donnell, L. J., Durdey, P., Mountford, R. A., and Clamp, J. R. (1993) The roles of enteric bacterial sialidase, sialate O-acetyl esterase and glycosulfatase in the degradation of human colonic mucin. Glycoconj. J. 10, 72-81.
30. Ogata, S., Koganty, R., Reddish, M., Longenecker, B. M., Chen, A. L., Perez, C., and Itzkowitz, S. H. (1998) Different modes of sialyl-Tn expression during malignant transformation of human colonic mucosa. Glycoconj. J. 15, 29-35.
31. Ogata, S., Chen, A., and Itzkowitz, S. H. (1994) Use of model cell lines to study the biosynthesis and biological role of cancer-associated sialosyl-Tn antigen. Cancer Res. 54, 4036-4044.
32. Brockhausen, I., Yang, J., Dickinson, N., Ogata, S., and Itzkowitz, S. H. (1998) Enzymatic basis for sialyl-Tn expression in human colon cancer cells. Glycoconj. J. 15, 595-603.