Simple and simultaneous analysis of fenfluramine, amphetamine and methamphetamine in whole blood by gas chromatography-mass spectrometry after headspace-solid phase microextraction and derivatization

Forensic Science International

Volumn 109, Issue 3, 2000, Pages 215-223

  Namera, Akira ^a   Yashiki, Mikio ^a   Liu, Junting ^a   Okajima, Kazuo ^a,b   Hara, Kenji ^c   Imamura, Tohru ^a   Kojima, Tohru ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b Department of Radiology   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

Author keywords

Amphetamine; Analysis; Fenfluramine; Methamphetamine; Whole blood

Indexed keywords

AMPHETAMINE; FENFLURAMINE; METHAMPHETAMINE;

ADULT; ARTICLE; BLOOD; DERIVATIZATION; DRUG ANALYSIS; DRUG DETERMINATION; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

EID: 0034630212     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(00)00145-6     Document Type: Article

References (24)

1. Pinder R.M., Brogden R.N., Sawyer P.R., Speight T.M., Avery G.S. Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. Drugs. 10:1975;241-323.
2. Gold R.G., Gordon H.E., D da Costa R.W., Porteous I.B., Kimber K.J. Fenfluramine overdosage. Lancet. 2:1969;1306.
3. Fleisher M.R., Campbell D.B. Fenfluramine overdosage. Lancet. 2:1969;1306-1307.
4. Kintz P., Mangin P. Toxicological findings after fatal fenfluramine self-poisoning. Hum. Exp. Toxicol. 11:1992;51-52.
5. Brownsill R., Wallace D., Taylor A., Campbell B. Study of human urinary metabolism of fenfluramine using gas chromatography-mass spectrometry. J. Chromatogr. 562:1991;267-277.
6. Srinivas N.R., Hubbard J.W., Cooper J.K., Midha K.K. Enantioselective gas chromatographic assay with electron-capture detection for dl-fenfluramine and dl-norfenfluramine in plasma. J. Chromatogr. 433:1988;105-117.
7. Krebs H.A., Cheng L.K., Wright G.J. Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. J. Chromatogr. 310:1984;412-417.
8. Caccia S., Jon A. Gas-liquid chromatographic determination of the optical isomers of fenfluramine and norfenfluramine in biological samples. J. Chromatogr. 144:1977;127-131.
9. Moeller M.R., Steinmeyer S., Kraemer T. Determination of drugs of abuse in blood. J. Chromatogr. B. 713:1998;91-109.
10. Kraemer T., Maurer H.H. Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine. J. Chromatogr. B. 713:1998;163-187.
11. Nagasawa N., Yashiki M., Iwasaki Y., Hara K., Kojima T. Rapid analysis of amphetamines in blood using head space-solid phase microextraction and selected ion monitoring. Forensic Sci. Int. 78:1996;95-102.
12. Arthur C.L., Pawliszyn J. Solid phase microextraction with fused silica optical fibers. Anal. Chem. 62:1990;2145-2148.
13. Yashiki M., Kojima T., Miyazaki T., Nagasawa N., Y Iwasaki K. Hara, Detection of amphetamines in urine using head space-solid phase microextraction and chemical ionization selected ion monitoring. Forensic Sci. Int. 76:1995;169-177.
14. Ishii A., Seno H., Kumazawa T., et al. Simple clean-up of methamphetamine and amphetamine in human urine by direct-immersion solid phase microextraction (DI-SPME). Jpn. J. Forensic Toxicol. 14:1996;228-232.
15. Ameno K., Fuke C., Ameno S., Kinoshita H., Ijiri I. Application of a solid-phase microextraction technique for the detection of urinary methamphetamine and amphetamine by gas chromatography. Can. Soc. Forensic Sci. J. 29:1996;43-48.
16. Centini F., Masti A., Comparini I.B. Quantitative and qualitative analysis of MDMA. MDEA, MA and amphetamine in urine by headspace/solid phase micro-extraction (SPME) and GC/MS. Forensic Sci. Int. 83:1996;161-166.
17. Lord H.L., Pawliszyn J. Method optimization for the analysis of amphetamines in urine by solid-phase microextraction. Anal. Chem. 69:1997;3899-3906.
18. Ugland H.G., Krogh M., Rasmussen K.E. Aqueous alkylebloroformate derivatisation and solid-phase microextraction: determination of amphetamines in urine by capillary gas chromatography. J. Chromatogr. B. 701:1997;29-38.
19. Battu C., Marquet P., Fauconnet A.L., Lacassie E., Lachatre G. Screening procedure for 21 amphetamine-related compounds in urine using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. Sci. 36:1998;1-7.
20. Koide I., Noguchi O., Okada K., et al. Determination of amphetamine and methamphetamine in human hair by headspace solid-phase microextraction and gas chromatography with nitrogen-phosphorus detection. J. Chromatogr. B. 707:1998;99-104.
21. Hara K., Nagata T., Kimura K. Forensic toxicologic analysis of methamphetamine and amphetamine in body materials by gas chromatography/mass spectrometry. Z. Rechtsmed. 96:1986;93-104.
22. Zhang Z., Pawliszyn J. Headspace solid phase microextraction. Anal. Chem. 65:1993;1843-1852.
23. Arthur C.L., Killam L.M., Buchholz K.D., Pawliszyn J. Automation and optimization of solid-phase microextraction. Anal. Chem. 64:1992;1960-1966.
24. Richards R.P., Gordon B.H., Ings R.M., Campbell D.B., King L.J. The measurement of d-fenfluramine and its metabolite, d-norfenfluramine in plasma and urine with an application of the method to pharmacokinetic studies. Xenobiotica. 19:1989;547-553.