Inhibitory effects of an antisense oligonucleotide in an experimentally infected mouse model of influenza A virus

Biochemical and Biophysical Research Communications

Volumn 279, Issue 1, 2000, Pages 158-161

  Mizuta, Tadashi ^a   Fujiwara, Masatoshi ^a   Abe, Takayuki ^b   Miyano Kurosaki, Naoko ^b   Yokota, Tomoyuki ^a   Shigeta, Shiro ^a   Takaku, Hiroshi ^b  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Animal model; Antisense oligonucleotides; Gene therapy; Influenza A virus; Transfection reagent; Viral RNA polymerase gene

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; PB2 AS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EXPERIMENTAL INFECTION; FEMALE; GENE THERAPY; INFLUENZA VIRUS A; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURVIVAL RATE; VIROGENESIS; VIRUS DETECTION; VIRUS REPLICATION;

ANIMALIA; INFLUENZA A VIRUS;

EID: 0034627117     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3924     Document Type: Article

References (22)

1. Brief overview of control of genetic expression by antisense oligonucleotides and in vivo applications. Prospects for neurobiology
2. Specific regulation of gene expression by antisense, sense and antigene nucleic acids
3. Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors Proc
4. Antibody targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibited viral replication
5. Free and liposome-encapsulated double-stranded RNAs as inducers of interferon, interleukin-6, and cellular toxicity
6. Intracellular availability unmodified phosphorothioate and liposomally encapsulated oligodeoxyribonucleotides for antisense activity
7. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides
8. Gene transfer in vivo with DNA-liposome complexes: Safety and acute toxicity in mice
9. Inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by unmodified, phosphorothioated, and liposomally encapsulated oligonucleotides
10. Specific inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by liposomally endocapsulated antisense phosphorothioate oligonucleotides: Penetration and localization of oligonucleotides in clone 76 cells
11. Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells
12. Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A
13. Stability of small unilamellar liposomes in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components
14. Comparison of the three large polymerase proteins of influenza A, B, and C viruses
15. The three subunits of the polymerase and the nucleoprotein of influenza B virus are the minimum set of viral proteins required for expression of a model RNA template
16. Systemic gene expression after intravenous DNA delivery into adult mice
17. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
18. Improved DNA: Liposome complexes for increased systemic delivery and gene expression
19. Liposomal gene delivery: A complex package
20. In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle
21. Improved cationic lipid formulations for in vivo gene therapy
22. Systemic gene therapy: Biodistribution and long-term expression of a transgene in mice