The influence of combined Fpg- and MutY-deficiency on the spontaneous and γ-radiation-induced mutation spectrum in the lacZα gene of M13mp10

Mutation Research - DNA Repair

Volumn 461, Issue 3, 2000, Pages 189-195

  Kuipers, Gitta K ^a   Slotman, Ben J ^a   Poldervaart, Hester A ^a   Reitsma Wijker, Carola A ^a   Lafleur, M Vincent M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Base excision repair; Fpg deficiency; LacZ gene; M13; Mutation spectrum; MutY deficiency; radiation

Indexed keywords

ARTICLE; BASE MISPAIRING; CANCER; ESCHERICHIA COLI; EXCISION REPAIR; GAMMA IRRADIATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS;

BACTERIOPHAGE M13; BASE SEQUENCE; DNA DAMAGE; DNA GLYCOSYLASES; DNA PRIMERS; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; DOSE-RESPONSE RELATIONSHIP, RADIATION; ESCHERICHIA COLI PROTEINS; GAMMA RAYS; LAC OPERON; MUTATION; N-GLYCOSYL HYDROLASES;

EID: 0034626818     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(00)00050-1     Document Type: Article

References (26)

1. Nucleotide excision repair in Escherichia coli
2. DNA glycosylases
3. DNA glycosylases in the base excision repair of DNA
4. Yields of radiation-induced base products in DNA: Effects of DNA conformation and gassing conditions
5. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8oxodG
6. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions
7. Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome
8. Repair and replication of plasmids with site-specific 8-oxodG and 8-AAFdG residues in normal and repair-deficient human cells
9. Mutations in the mutY gene of Escherichia coli enhance the frequency of targeted G: C → T: A transversions induced by a single 8-oxoguanine residue in single-stranded DNA
10. Single-stranded shuttle plasmid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G: C → T: A transversions in simian kidney cells
11. The influence of formamido-pyrimidine-DNA glycosylase on the spontaneous and γ-radiation-induced mutation spectrum of the lacZα gene
12. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
13. A repair system for 8-oxo-7,8-dihydrodeoxyguanine
14. 60Co γ-rays induce predominantly C/G to G/C transversions in double-stranded M13 DNA
15. DNA sequencing with chain-terminating inhibitors
16. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA
17. Functional cooperation of MutT, MutM, MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli
18. A novel role for Escherichia coli endonuclease VIII in prevention of spontaneous G → T transversions
19. Instability and decay of the primary structure of DNA
20. DNA damages processed by base excision repair: Biological consequences
21. Specificity of spontaneous and t-butyl hydroperoxide-induced mutations in ΔoxyR strains of Escherichia coli differing with respect to SOS mutagenesis proficiency and to the MutY and MutM functions
22. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine
23. Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:guanine mispair to prevent spontaneous G: C → C: G transversions
24. Delayed transfection of DNA after riboflavin mediated photosensitization increases G:C to C:G transversions of supF gene in Escherichia coli mutY strain
25. Frameshift errors initiated by nucleotide misincorporation