Detection of single nucleotide polymorphisms of the human Mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: Potential in studies of addiction

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 5, 2000, Pages 604-615

  Steven LaForge, K ^a   Shick, Valentin ^b   Spangler, Rudolph ^a   Proudnikov, Dmitri ^b   Yuferov, Vadim ^a   Lysov, Yuri ^b   Mirzabekov, Andrei ^b   Kreek, Mary Jeanne ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

Addiction; Microchips; Mu opioid receptor; Polymorphism; SNP

Indexed keywords

BETA ENDORPHIN; MU OPIATE RECEPTOR; OPIATE;

ARTICLE; AUTOMATION; DNA HYBRIDIZATION; DNA SEQUENCE; DRUG DEPENDENCE; GENE AMPLIFICATION; GENE FREQUENCY; GENE TARGETING; GENETIC PREDISPOSITION; HERITABILITY; HUMAN; NUCLEIC ACID BASE SUBSTITUTION; OPIATE ADDICTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

DNA; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU; SEQUENCE ANALYSIS, DNA; SUBSTANCE-RELATED DISORDERS;

EID: 0034626401     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/1096-8628(20001009)96:5<604::AID-AJMG5>3.0.CO;2-F     Document Type: Article

References (87)

1. Further evidence for a quantitative trait locus on murine chromosome 10 controlling morphine preference in inbred mice
2. Effect of chronic cocaine treatment on μ and δ opioid receptor mRNA levels in dopaminergically innervated brain regions
3. Expression of two variants of the human μ opioid receptor mRNA in SK-N-SH cells and human brain
4. Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking
5. Chromosome mapping of gene loci affecting morphine and amphetamine responses in BDX recombinant inbred mice
6. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains
7. μ Opioid receptor gene variants: Lack of association with alcohol dependence
8. Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains
9. Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse
10. Single nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction
11. An adoption study demonstrating two genetic pathways to drug abuse
12. Characterization of single-nucleotide polymorphisms in coding regions of human genes
13. Accessing genetic information with high-density DNA arrays
14. Inheritance of alcohol abuse: Cross-fostering analysis of adopted men
15. Detection of sickle cell β(s)-globin allele by hybridization with synthetic oligonucleotides
16. Identifying genes for alcohol and drug sensitivity: Recent progress and future directions
17. Hypothalamic-pituitary-adrenal axis hypersensitivity to naloxone in opioid dependence: A case of naloxone induced withdrawal
18. Narcotic blockade
19. Sequence analysis by hybridization with oligonucleotide microchip: Identification of β-thalassemia mutations
20. Polymorphism analysis and gene detection by minisequencing on an array of gel-immobilized primers
21. Light directed, spatially addressable parallel chemical synthesis
22. Parallel thermodynamic analysis of duplexes on oligodeoxyribonucleotide microchips
23. 2 adrenergic receptor impart distinct agonist-promoted regulatory properties
24. The rapid detection of unknown mutations in nucleic acids
25. Manual manufacturing of oligonucleotide, DNA and protein microchips
26. Detection of heterozygous mutations in BCRA1 using high density oligonucleotide arrays and two-colour florescence analysis
27. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
28. PCR-SSCP: A simple and sensitive method for detection of mutations in the genomic DNA
29. How sensitive is PCR-SSCP?
30. SSCP analysis: A blind sensitivity trial
31. Cocaine use, abuse and dependence in a population-based sample of female twins
32. Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins
33. An oligonucleotide hybridization approach to DNA sequencing
34. A method for DNA sequencing by hybridization with oligonucleotide matrix
35. Murine chromosomal location of the μ and κ opioid receptor genes
36. Association of alcohol or other drug dependence with alleles of the μ opioid receptor gene (OPRM1)
37. Medical safety and side effects of methadone in tolerant individuals
38. Medical complications in methadone patients
39. Opiates, opioids and addiction
40. Opioid receptors: Some perspectives from early studies of their role in normal physiology, stress responsivity and in specific addictive diseases
41. Long-term pharmacotherapy for opiate (primarily heroin) addiction: Opioid agonists
42. Long-term pharmacotherapy for opiate (primarily heroin) addiction: Opioid antagonists and partial agonists
43. Chronic use of opioids and antipsychotic drugs: Side effects, effects on endogenous opioids and toxicity
44. Drug dependence: Stress and dysregulation of brain reward pathways
45. Effects of chronic exogenous opioid administration on levels of one endogenous opioid (beta-endorphin) in man
46. Naloxone, a specific opioid antagonist, reverses chronic idiopathic constipation
47. μ Opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality
48. A double-blind, placebo-controlled pilot study to evaluate the efficacy and safety of oral nalmefene HCl for alcohol dependence
49. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioidreceptor gene
50. Familial transmission of substance use disorders
51. The human μ opioid receptor: Modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C
52. A simple salting out procedure for extracting DNA from human nucleated cells
53. The genetics of pain and pain inhibition
54. Natural killer cell activity and lymphocyte subsets in parenteral heroin abusers and long-term methadone maintenance patients
55. Naltrexone and coping skills therapy for alcohol dependence: A controlled study
56. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
57. DNA sequencing by hybridization to microchip octa- and decanucleotides extended by stacked pentanucleotides
58. Pharmacological mechanisms of opioid analgesics
59. Mini-sequencing: A specific tool for DNA analysis and diagnostics on oligo-nucleotide arrays
60. Array-based multiplex analysis of candidate gene reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population
61. Heterogeneity in the inheritance of alcoholism
62. Immobilization of DNA in polyacrylamide gel for the manufacture of DNA and DNA-oligonucleotide microchips
63. Human μ-opioid receptor variation and alcohol dependence
64. Characterization of polymerase chain reaction amplification of specific alleles
65. Nalmefene causes greater hypothalamic-pituitary-adrenal axis activation than naloxone in normal volunteers: Implications for the treatment of alcoholism
66. Identification of HLA DQA1 alleles by the oligonucleotide microchip method
67. Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia
68. Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models
69. From gels to chips: 'Minisequencing' primer extension for analysis of point mutations and single nucleotide polymorphisms
70. A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E
71. Altered hematopoiesis, behavior, and sexual function in μ opioid receptor-deficient mice
72. Regioselective immobilization of short oligonucleotides to acrylic copolymer gels
73. Genetic influences on DSM-III-R drug abuse and dependence: A study of 3,372 twin pairs
74. Co-occurrence of abuse of different drugs in men
75. The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses
76. Chronic cocaine alters brain mu opioid receptors
77. Repeated cocaine administration upregulates κ and μ, but not δ, opioid receptors
78. Naltrexone in the treatment of alcohol dependence
79. Human μ opiate receptor cDNA and genomic clones, pharmacologic characterization and chromosomal assignment
80. Large scale identification, mapping and genotyping of single-nucleotide polymorphisms in the human genome
81. The human μ opioid receptor gene: 5' Regulatory and intronic sequences
82. Detecting single base substitutions as heteroduplex polymorphisms
83. Allele-specific enzymatic amplification of β-globin genomic DNA for diagnosis of sickle cell anemia
84. DNA Analysis and diagnostics on oligonucleotide microchips
85. Acute 'binge' cocaine increases μ-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system
86. Increased μ opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving