Dynamic modeling of EDG1 receptor structural changes induced by site-directed mutations

Journal of Molecular Structure: THEOCHEM

Volumn 529, Issue 1-3, 2000, Pages 219-224

  Bautista, D L ^a   Baker, D L ^b   Wang, D ^b   Fischer, D J ^b   Van Brocklyn, J ^c   Spiegel, S ^c   Tigyi, G ^b   Parrill, A L ^a  

^a UNIVERSITY OF MEMPHIS   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

Endothelial differentiation gene; G protein coupled receptor; Molecular dynamics; Solvent accessible surface area; Sphingosine 1 phosphate

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; PHOSPHOLIPID; SPHINGOSINE 1 PHOSPHATE;

BINDING AFFINITY; CONFERENCE PAPER; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR GENE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 0034623279     PISSN: 01661280     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-1280(00)00549-2     Document Type: Conference Paper

References (34)

1. Differential pharmacological properties and signal transduction of the sphingosine-1-phosphate receptors EDG-1, EDG-3, and EDG-5
2. Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator
3. A family of phospholipid autacoids: Occuttence, metabolism, and bioactions
4. Lysophosphatidic acid: G protein signaling and cellular responses
5. Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophophatidic acid from Xenopus oocytes
6. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist
7. Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes
8. Phospholipid growth factors: Identification and mechanism of action
9. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
10. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids
11. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine-1-phosphate receptors
12. A novel membrane receptor with high affinity for lysopshingomyelin and sphingosine-1-phosphate in atrial myocytes
13. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6
14. The transmembrahe 7-a-bundle of rhodopsin: Distance geometry calculations with hydrogen bonding constraints
15. Projection structure of rhodopsin
16. A general method applicable to the search for similarities in the amino acid sequences of two proteins
17. The protein data bank: A computer based archival file for macro-molecular structures
18. Using known substructures in protein modeling and crystallography
19. Accurate modeling of protein conformation by automatic segment matching
20. Prediction of protein three-dimensional structures in insertion and deletion regions: A procedure for searching data bases of representative protein fragments using geometric scoring criteria
21. Polarity conserved positions in trans-membrane domains of G-protein coupled receptors and bacteriorhodopsin
22. Merck molecular force field. I. Basis form, scope parameterization, and preformance of MMFF94(*)
23. Structural features of EDG1 receptor-ligand complexes revealed by computational modeling and mutagenesis
24. A second generation force field for the simulation of proteins, nucleic acids, and organic molecules
25. Different β-subunits determine G-protein interaction with transmembrane receptors
26. The 2.0 Å crystal structure of a heterotrimeric G protein
27. Diversity of G proteins in signal transduction
28. G-protein-coupled receptor heterodimerization modulates receptor function
29. A peptide agonist acts by occupation of a monomeric G protein-coupled receptor: Dual sites of covalent attachment to domains near TM1 and TM7 of the same molecule make biologically significant domain-swapped dimerization unlikely
30. Three-dimensional structure of the cytoplasmic face of the G protein receptor rhodopsin
31. A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an Asn-Pro/Asp-Pro motif