Proconvulsive effects of the mitochondrial respiratory chain inhibitor - 3-nitropropionic acid

European Journal of Pharmacology

Volumn 403, Issue 3, 2000, Pages 229-233

  Haberek, Grzegorz ^a   Tomczyk, Tomasz ^a   Zuchora, Beata ^a   Wielosz, Marian ^a   Turski, Waldemar A ^a,b   Urbanska, Ewa M ^a,b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

Author keywords

3 Nitropropionic acid; 4 Aminopyridine; Electroconvulsion; GABA ( aminobutyric acid); Mitochondrial toxin; Seizure

Indexed keywords

3 NITROPROPIONIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOPYRIDINE; AMINOOXYACETIC ACID; BICUCULLINE; GLYCINE RECEPTOR ANTAGONIST; PENTETRAZOLE; PICROTOXIN; PILOCARPINE; STRYCHNINE;

ANIMAL MODEL; ARTICLE; CONVULSION; ELECTRIC CURRENT; LD 50; MALE; MITOCHONDRIAL RESPIRATION; MORTALITY; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SEIZURE; TONIC CLONIC SEIZURE;

ACETYLCHOLINE; ANIMALS; CONVULSANTS; DRUG INTERACTIONS; ELECTRIC STIMULATION; ELECTRON TRANSPORT; ELECTROSHOCK; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLYCINE; KYNURENIC ACID; MALE; MICE; NITRO COMPOUNDS; POTASSIUM CHANNELS; PROPIONIC ACIDS; SEIZURES; SYNAPTIC TRANSMISSION;

EID: 0034623262     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00510-0     Document Type: Article

References (17)

1. Alston T.A., Mela L., Bright H.J. 3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase. Proc. Natl. Acad. Sci. U. S. A. 74:1977;3767-3771.
2. Beal M.F., Brouillet E., Jenkins B.G., Ferrante R.J., Kowall N.W., Miller J.M., Storey E., Srivastava R., Rosen B.R., Hyman B.T. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13:1993;4181-4192.
3. Borlongan C.V., Nishino H., Sanberg P.R. Systemic, but not intraparenchymal, administration of 3-nitropropionic acid mimics the neuropathology of Huntington's disease: a speculative explanation. Neurosci. Res. 28:1997;185-189.
4. Buckle P.J., Haas H.L. Enhancement of synaptic transmission by 4-aminopyridine in hippocampal slices of the rat. J. Physiol. (London). 326:1982;109-122.
5. De Deyn P.P., D'Hooge R., Marescau B., Pei Y.Q. Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants. Epilepsy Res. 12:1992;87-110.
6. Greene J.G., Greenamyre J.T. Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48:1996;613-634.
7. Lees G.J. Contributory mechanisms in the causation of neurodegenerative disorders. Neuroscience. 54:1993;287-322.
8. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-111.
9. Ludolph A.C., He F., Spencer P.S., Hammerstad J., Sabri M. 3-Nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin. Can. J. Neurol. Sci. 18:1991;492-498.
10. Ludolph A.C., Seelig M., Ludolph A., Novitt P., Allen C.N., Spencer P.S., Sabri M.I. 3-Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants. Neurodegeneration. 1:1992;155-161.
11. Löscher W., Schmidt D. Which animal model should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2:1988;145-181.
12. Turski W.A., Cavalheiro E.A., Schwarz M., Czuczwar S.J., Kleinrok Z., Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav. Brain Res. 9:1983;315-335.
13. Turski W.A., Dziki M., Urbanska E., Calderazzo-Filho L.S., Cavalheiro E.A. Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. Synapse. 7:1991;173-180.
14. Urbanska E., Blaszczak P., Saran T., Kleinrok Z., Turski W.A. Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. Eur. J. Pharmacol. 359:1998;55-58.
15. Urbanska E.M., Blaszczak P., Saran T., Kleinrok Z., Turski W.A. AMPA/kainate-related mechanisms contribute to convulsant and proconvulsant effects of 3-nitropropionic acid in mice. Eur. J. Pharmacol. 370:1999;251-256.
16. Wallace D.C., Lott M.T., Shoffner J.M., Ballinger S. Mitochondrial DNA mutations in epilepsy and neurological disease. Epilepsia. 35:1994;S43-S50.
17. Yamaguchi S., Rogawski M.A. Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice. Epilepsy Res. 11:1992;9-16.