Gilbert's, conjecture: The search for DNA (cytosine-5) demethylases and the emergence of new functions for eukaryotic DNA (cytosine-5) methyltransferases

Journal of Molecular Biology

Volumn 302, Issue 1, 2000, Pages 1-7

  Smith, Steven S ^a  

^a Department of Cell and Tumor Biology ^*  (United States)

Author keywords

Chromosome stability; Demethylase; DNA methyltransferase; Gene expression; Methylation

Indexed keywords

5 METHYLCYTOSINE; CYTOSINE DERIVATIVE; DNA (CYTOSINE 5) METHYLTRANSFERASE;

DNA METHYLATION; DNA RECOMBINATION; DNA REPAIR; DNA STRUCTURE; ENZYME ANALYSIS; EUKARYOTE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC STABILITY; PRIORITY JOURNAL; REVIEW;

EUKARYOTA;

EID: 0034623007     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4046     Document Type: Review

References (62)

1. Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA
2. Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells
3. A mammalian protein with specific demethylase activity for mCpG DNA
4. Characterization of the human DNA methyltransferase splice variant Dnmtlb
5. Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene
6. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
7. DNA hypomethylation leads to elevated mutation rates
8. Hairpins are formed by the single DNA strands of the fragile X triplet repeats: Structure and biological implications
9. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21(WAF1)
10. The amazing demethylase
11. 5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation
12. Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA
13. Eukaryotic DNA methylation as an evolutionary device
14. Interchromosomal transfer of epigenetic states in Ascobolus: Transfer of DNA methylation is mechanistically related to homologous recombination
15. Recognition of stereo chemical paths by orbital interaction
16. Concluding remarks
17. Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells
18. Induction of thymidine kinase in enzyme-deficient chinese hamster cells
19. Bisulfite modification of nucleic acids and their constituents
20. Hypermethylated SUPERMAN epigenetic alleles in Arabidopsis
21. Ectopic hypermethylation of flower-specific genes in Arabidopsis
22. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
23. Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase
24. The RNA moiety of chick embryo 5-methylcytosine-DNA glycosylase targets DNA demethylation
25. Stalling of human DNA (cytosine-5) methyltransferase at single-strand conformers from a site of dynamic mutation
26. Cytidine methylation of regulatory sequences near the π-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
27. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
28. Enzymatic methylation of DNA-roles and prospects
29. An inverted repeat triggers cytosine methylation of identical sequences in Arabidopsis
30. Absence of genome-wide changes in DNA methylation during development of the zebrafish
31. Demethylation of the zygotic paternal genome
32. Arabidopsis PAI gene arrangements, cytosine methylation and expression
33. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
34. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
35. Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome
36. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
37. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
38. Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: Possible in vivo relevance during tumorigenesis
39. Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation
40. DNA methylation is a reversible biological signal
41. Epimutation of repeated genes in Ascobolus immersus
42. Base flipping
43. Carpel, a new Arabidopsis epi-mutant of the SUPERMAN gene: Phenotypic analysis and DNA methylation status
44. Reactions of cytosine derivatives with acidic buffer solutions. II. Studies on transamination, deamination, and deuterium exchange
45. Mechanism of inhibition of DNA(Cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine
46. DNA-methyltransferase SsoII interaction with own promoter region binding site
47. The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha demethylase of Candida albicans (Other names are: Lanosterol 14 alpha-demethylase, P-450(14DM), and CYP51)
48. Feedback regulation of DNA methyltransferase gene expression by methylation
49. DNA methylation in eukaryotic chromosome stability revisited: DNA methyltransferase in the management of DNA conformation space
50. Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation
51. Recognition of unusual DNA structures by human DNA (cytosine-5) methyltransferase
52. Hypermethylation of telomerelike foldbacks at codon 12 of the human c-Ha-ras gene and the trinucleotide repeat of the FMR-1 gene of fragile X
53. Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts
54. Drosophila melanogaster genomic DNA sequence homologous to mammalian cytosine DNA-methyltransferase gene
55. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
56. RNA-directed de novo methylation of genomic sequences in plants
57. DNA demethylation in vitro: Involvement of RNA
58. The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue
59. Imprinted expression of the Igf2r gene depends on an intronic CpG island
60. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
61. A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast