Production of nitroxyl (HNO) at biologically relevant temperatures from the retro-Diels-Alder reaction of N-hydroxyurea-derived acyl nitroso-9,10- dimethylanthracene cycloadducts

Tetrahedron Letters

Volumn 41, Issue 22, 2000, Pages 4265-4269

  Xu, Yueping ^a   Alavanja, Maria Michelle ^a   Johnson, Veta L ^a   Yasaki, Genichiro ^a   King, S Bruce ^a  

^a WAKE FOREST UNIVERSITY   (United States)

Author keywords

Acyl nitroso compounds; N hydroxyureas; Nitric oxide; Nitroxyl; Retro Diels Alder

Indexed keywords

ANTHRACENE DERIVATIVE; HYDROXYUREA; NITROUS OXIDE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DECOMPOSITION; HYDROLYSIS; NONHUMAN; OXIDATION; SPECTROPHOTOMETRY;

EID: 0034622088     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00670-5     Document Type: Article

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20. 2: C, 54.54; H, 6.54; N, 18.17. Found: C, 54.71; H, 6.94; N, 18.43. Cycloadducts 4a-d slowly decompose to 9,10-DMA at room temperature. Storage of these compounds in a freezer prevents thermal decomposition.