Chlorophyllin [CHLN] and the mutagenicity of monofunctional alkylating agents in Drosophila: The action of CHLN need not include an influence on metabolic activation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 467, Issue 2, 2000, Pages 113-117

  Olvera, O ^a   Arceo, C ^a   Zimmering, S ^b  

^a INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES   (Mexico)

^b BROWN UNIVERSITY   (United States)

Author keywords

Chlorophyllin; Direct and indirect acting; Drosophila; Inhibition; Monofunctional alkylating agents; Somatic cells

Indexed keywords

ALKYLATING AGENT; ANTIMUTAGENIC AGENT; CHLOROPHYLL; DIETHYLNITROSAMINE; ETHYLNITROSOUREA; MESYLIC ACID METHYL ESTER; METHYLNITROSOUREA; NITROSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; FORELIMB; LARVA; MALE; METABOLIC ACTIVATION; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SOMATIC CELL;

ALKYLATING AGENTS; ANIMALS; ANTIMUTAGENIC AGENTS; CHLOROPHYLLIDES; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; ETHYLNITROSOUREA; FEMALE; MALE; METHYL METHANESULFONATE; METHYLNITROSOUREA; MUTAGENESIS; MUTAGENICITY TESTS; WING;

EID: 0034621391     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00025-5     Document Type: Article

References (6)

1. Romert L.M., Curval M., Jennsen D. Chlorophyllin is both a positive and negative modifier of mutagenesis. Mutagenesis. 7:1992;349-355.
2. Graf U., Wurgler F.E., Katz A.J., Frei H., Juon H., Hall C.B., Kale P.G. Somatic mutation and recombination test in Drosophila melanogaster. Environ. Mutagen. 6:1984;153-188.
3. Lindsley D., Zimmer E. The Genome of Drosophila melanogaster. 1985;Univ. California, San Diego, La Jolla.
4. Olvera O., Zimmering S., Cruces M.P., Pimentel E., Arceo C., Guzman J., de la Rosa M.E. Ohigashi H., Osawa T., Terao J., Watanabe S., Yoshikawa T. Food Factors for Cancer Prevention. 1997;567-571.
5. Abraham S.K., Sarma L., Kesavan P.C. Role of chlorophyllin as an anticlastogen: protection against gamma-radiation and chemical clastogens. Mutat. Res. 322:1994;209-212.
6. Neault J.F., Tajmir-Riahi H.A. DNA-chlorophyllin interaction. Mutat. Res. 322:1998;209-212.