Occupational exposure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase

Toxicology

Volumn 150, Issue 1-3, 2000, Pages 1-29

  Storm, Jan E ^a   Rozman, Karl K ^a,b   Doull, John ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Acetylcholinesterase inhibition; Occupational exposure limits; Organophosphate pesticides; Review

Indexed keywords

ACETYLCHOLINESTERASE; ORGANOPHOSPHATE PESTICIDE;

ACUTE TOXICITY; CHOLINESTERASE INHIBITION; DATA BASE; ERYTHROCYTE; HUMAN; INHALATION; LC 50; LD 50; MAXIMUM ALLOWABLE CONCENTRATION; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TOXICOKINETICS;

EID: 0034618652     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00219-5     Document Type: Article

References (56)

1. American Conference of Governmental Industrial Hygienists (ACGIH) 1991. Documentation of the threshold limit values and biological exposures indices, 6th edn. ACGIH, Cincinnati, OH.
2. American Conference of Governmental Industrial Hygienists (ACGIH) 1998. TLVs and BEIs. Threshold limit values for chemical stubstances and physical agents. Biological Exposure Indices (Booklet). ACGIH, Cincinnati, OH.
3. Anzueto A., Berdine G.G., Moore G.T., Gleiser C., Johnson D., White C.D., Johanson W.G. Jr. Pathophysiology of soman intoxication in primates. Toxicol. Appl. Pharmacol. 86:1986;56-68.
4. Atterberry T.T., Burnett W.T., Chambers J.E. Age-related differences in parathion and chlorpyrifos toxicity in male rats: target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism. Toxicol. Appl. Pharmacol. 147:1997;411-418.
5. Atterberry J.D., Durham W.F., Elliott J.W., Wolfe H.R. Exposure to parathion: measurement by blood cholinesterase level and urinary p-nitrophenol excretion. Arch. Environ. Health. 3:1961;112-121.
6. Ballantyne B., Marrs T.C. Overview of the biological and clinical aspects of organophosphates and carbamates. Ballantyne B., Marrs T.C. Clinical and Experimental Toxicology of Organophosphates and Carbamates. 1992;3-14 Butterworth-Heinemann, Oxford.
7. Butler A.M., Murray M. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J. Pharmacol. Exp. Ther. 280:1997;966-973.
8. Carr R.L., Chambers J.E. Acute effects of the organophosphate paraoxon on schedule-controlled behavior and esterase activity in rats: dose-response relationships. Pharmacol. Biochem.Behav. 40:1991;929-936.
9. Chambers H., Brown B., Chambers J.E. Noncatalytic detoxication of six organophosphorus compounds by rat liver homogenates. Pesticide Biochem. Physiol. 36:1990;308-315.
10. Chambers H.W. Organophosphorus compounds: an overview. Chambers P.E., Levi J.E. Organophosphates. Chemistry, Fate and Effects. 1992;3-18 Academic Press, San Diego, CA.
11. Chambers J.E., Carr R.L. Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats. Fundam. Appl. Toxicol. 21:1993;111-119.
12. Chambers J.E., Ma T., Boone J.S., Chambers H.W. Role of detoxication pathways in acute toxicity levels of phosphorothinate insecticides in the rat. Life Sci. 54:1994;1357-1364.
13. Durham W.F., Wolfe H.R. Measurement of the exposure of workers to pesticides. WHO Bull. 26:1962;75-91.
14. Durham W.F., Wolfe H.R., Ellliott J.W. Abosrption and excretion of parathion by spraymen. Arch. Environ. Health. 24:1972;381-387.
15. Environmental Protection Agency (EPA), 1998a. Science policy on the use of data on cholinesterase inhibition for risk assessment. Office of Pesticide Programs. Fax-on-demand (202-401-0527). Item 6022.
16. Environmental Protection Agency (EPA), 1998b. Status of pesticides in registration, Reregistration and Special Review. EPA 738-R-98-002.
17. Environmental Protection Agency (EPA), 1998c. Health effects division toxicity chapter for disulfoton for reregistration eligibility decision (RED). Office of Prevention, Pesticides and Toxic Substances.
18. Environmental Protection Agency (EPA), 1998d. The HED chapter of the reregistration eligibility decision document (RED) for azinphos-methyl. Office of Prevention, Pesticides and Toxic Substances.
19. Environmental Working Group (EWG), 1998. The English Patients. Human experiments and pesticide policy. Environmental Working Group/The Tides Center, Washington, DC (www.ewg.org).
20. Frawley J.P., Hagan E.C., Fitzhugh O.G. A comparative pharmacological and toxicological study of organic phosphate-anticholinesterase compounds. J. Pharmacol. Exp. Ther. 105:1952;156-165.
21. Furlong C.E. Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorifos oxon and paraoxon. Am. J. Hum. Genet. 43:1988;230-238.
22. Furlong E.E. Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase. Anal. Biochem. 180:1989;242-247.
23. Gad S., Weil C.S. Statistics And Experimental design for Toxicologists. 1991;CRC Press, Boca Raton, FL.
24. Gaines T.B., Kimbrough R., Laws E.R. Toxicology of abate in laboratory animals. Arch. Environ. Health. 14:1967;283-288.
25. Gallo M.A., Lawryk N.J. Organic Phosphorus Pesticides. Hayes W. Handbook of Pesticide Toxicology. II:1991;917-1090 Academic Press, New York.
26. Hattis D., Barlow K. Human interindividual variability in cancer risks-technical and management challenges. Hum. Ecol. Risk Assess. 2:1996;194-220.
27. Hosokawa M., Endo T., Fujisawa M., Hara S., Iwata N., Sato Y., Satoh T. Interindividual variation in carboxylesterase levels in human liver microsomes. Drug. Metab. Dispos. 23:1995;1022-1027.
28. Jett D.A., Fernando J.C., Eldefrawi M.E., Eldefrawi A. Differential regulation of muscarinic receptor subtypes in rat brain regions by repeated injections of parathion. Toxicol. Lett. 73:1994;33-41.
29. Johnson J.A., Wallace K.B. Species-related differences in the inhibition of brain acetylcholinesterase by paraoxon and malaoxon. Toxicol. Appl. Pharmacol. 88:1987;234-241.
30. Kemp J.R., Wallace K.B. Molecular determinants of the species-selective inhibition of brain acetylcholinesterase. Toxicol. Appl. Pharmacol. 104:1990;246-258.
31. Kimmerle G., Klimmer O.R. Acute and subchronic toxicity of sulfotep. Arch. Toxicol. 33:1974;1-16.
32. Ma T., Chambers J.E. Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes. Food Chem. Toxicol. 32:1994;763-767.
33. Ma T., Chambers J.E. A kinetic analysis of hepatic microsomal activation of parathion and chlorpyrifos in control and phenobarbital-treated rats. J. Biochem. Toxicol. 10:1995;63-68.
34. Maxwell D.M., Lenz D.E. Structure-activity relationships and anticholinesterase activity. Ballantyne B., Marrs T.C. Clinical and Experimental Toxicology of Organophosphates and Carbamates. 1992;47-58 Butterwort-Heinemann, Oxford.
35. McCollister D.D., Oyen F., Rowe V. Toxicological studies of O,O-Dimethyl-O-(2,4,5-trichlorophenyl) phosphorothioate (ronnel) in laboratory animals. J. Agric. Food Chem. 7:1959;689-693.
36. Meister, R.T. (Ed.), 1995. Farm Chemicals Handbook '95. Meister Publishing Co., Willoughby, OH.
37. Mileson B.E., Chambers J.E., Chen W.L., Dettbarn W., Ehrich M., Eldefrawi A.T., Gaylor D.W., Hamernik K., Hodgson E., Karczmar A.G., Padilla S., Pope C.N., Richardson R.J., Saunders D.R., Sheets L.P., Sultatos L.G., Wallace K.B. Common mechanism of toxicity: a case study of organophosphorus pesticides. Toxicol. Sci. 41:1998;8-20.
38. Milsom W.K. Comparative aspects of vertebrate pulmonary mechanics. Wood S.C. Comparative Pulmonary Physiology. Current Concepts. 1989;587-600 Marcel Dekker, New.
39. Neal R.A., DuBois K.P. Studies on the mechanism of detoxification of cholinergic phosphorothioates. J. Pharmacol. Exp. Ther. 148:1965;185-192.
40. Nostrandt A.C., Padilla S., Moser V. The relationship of oral chlorpyrifos: effects on behavior, cholinesterase inhibition, and muscarinic receptor density in rats. Pharmacol. Biochem. Behav. 58:1997;15-23.
41. Padilla S. Regulatory and research issues related to cholinesterase inhibition. Toxicology. 102:1995;215-220.
42. Padilla S., Wilson V.Z., Bushnell P.J. Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats. Toxicology. 92:1994;11-25.
43. Pond A.L., Chambers H.W., Chambers J.E. Organophosphate detoxication potential of various rat tissues via A-esterase and aliesterase activities. Toxicol. Lett. 78:1995;245-252.
44. Richardson R.J. Assessment of the neurotoxic potential of chlorpyrifos relative to other organophosphorus compounds: A Critical Review of the Literature. J. Toxicol. Environ. Health. 44:1995;135-165.
45. Rozman K.K. Delayed acute toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD), after oral administration, obeys Haber's rule of inhalation toxicology. Toxicol. Sci. 49:1999;102-109.
46. Sidell G.T. Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates. Clin. Toxicol. 7:1974;1-17.
47. Storm J.E., Rozman K.K. Evaluation of alternative models for establishing safe levels of occupational exposure to vinyl halides. Regul. Toxicol. Pharmacol. 25:1997;240-255.
48. Storm J.E., Rozman K.K. Derivation of an occupational exposure limit (OEL) for methylene chloride based on acute CNS effects and relative potency analysis. Regul. Toxicol. Pharmacol. 27:1998;240-250.
49. Sultatos L.G. Factors affecting the hepatic biotransformation of the phosphorothioate pesticide Chlorpyrifos. Toxicology. 51:1988;191-200.
50. Sultatos L., Huang G., Jackson O., Reed K., Soranno T.M. The effect of glutathione monoethyl ester on the potentiation of the acute toxicity of methyl parathion, methyl paraoxon or fenitrothion by diethyl maleate in the mouse. Toxicol. Lett. 55:1991;77-83.
51. Thorpe E., Wilson A.B., Dix K.M. Teratological studies with dichlorvos vapor in rabbits and rats. Arch. Toxicol. 30:1972;29-38.
52. Wang C., Murphy S.D. Kinetic analysis of species differences in acetylcholinesterase sensitivity to organophosphate insecticides. Toxicol. Appl. Pharmacol. 66:1982;409-419.
53. Winthrobe M.M., Lee G.R. Hematologic Alterations. Winthrobe M.M., Thorn G.W., Adams R.D., Braunwald E., et al. Harrisons Principles of Internal Medicine. 1974;28-38 McGraw-Hill, New York.
54. World Health Organization (WHO), 1996. Biological Monitoring of Chemical Exposure in the Workplace. Guidelines Ch. 5. Selected Pesticides. WHO, Geneva.
55. Wolfe H.R., Staiff D.C., Armstron J.F., Davis J.E. Exposure of fertilizer mixing plant workers to disulfoton. Bull. Environ. Contam. Toxicol. 20:1978;79-86.
56. Zhang H.X., Sultatos L.G. Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ. Drug Metab. Dispos. 19:1991;473-477.