Tolerance to cadmium hepatotoxicity by metallothionein and zinc: In vivo and in vitro studies with MT-null mice

Toxicology

Volumn 150, Issue 1-3, 2000, Pages 53-67

  Coyle, Peter ^a   Niezing, Geralt ^a   Shelton, Tanya L ^a   Philcox, Jeffrey C ^a   Rofe, Allan M ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Cadmium; Cultured mouse hepatocytes; Dexamethasone; Metallothionein; Zinc

Indexed keywords

ALANINE AMINOTRANSFERASE; CADMIUM; DEXAMETHASONE; GLUCOSE; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER PROTECTIVE AGENT; METALLOTHIONEIN; PROGESTERONE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CYTOSOL; LIVER LEVEL; LIVER MITOCHONDRION; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CADMIUM; CELLS, CULTURED; DEXAMETHASONE; GLUTATHIONE; HEPATOCYTES; LIVER; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; ZINC;

EID: 0034618650     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00243-2     Document Type: Article

References (41)

1. Abel J., de Ruiter N. Inhibition of hydroxyl-radical-generated DNA degredation by metallothionein. Toxicol. Lett. 47:1989;191-196.
2. Basu A., Lazo J.S. A hypothesis regarding the protective role of metallothioneins against the toxicity of DNA interactive anticancer drugs. Toxicol. Lett. 50:1990;123-135.
3. Bell R.R., Soliman M.R., Early J.L. Acute effects of cadmium and selenium on glucose output from rat liver hepatocytes using various gluconeogenic precursors. Toxicology. 65:1990;161-168.
4. Bergmeyer H.U., Bergmeyer J., GraBl M. third ed Methods of Enzymatic Analysis. 3:1983;605 Verlag Chemic, Basel.
5. Bracken W.M., Klaassen C.D. Induction of metallothionein in rat primary hepatocyte cultures: evidence for direct and indirect induction. J. Toxicol. Environ. Health. 22:1987;163-174.
6. Conrad C.C., Walter C.A., Richardson A., Hanes M.A., Grabowski D.T. Cadmium toxicity and distribution in metallothionein-I and II deficient transgenic mice. J. Toxicol. Environ. Health. 52:1997;527-543.
7. Cousins R.L, Dunn M.A., Leinart A.S., Yedinak K.C., DiSilvestro R.A. Coordinate regulation of zinc metabolism and metallothionein gene expression in rats. Am. J. Physiol. 251:1986;E688-E694.
8. Coyle P., Philcox J.C., Rofe A.M. Corticosterone enhances the zinc and interleukin-6-mediated induction of metallothionein in cultured rat hepatocytes. J. Nutr. 123:1993;1464-1470.
9. Coyle R, Zalewski P.D., Philcox J.C., Forbes I.L, Ward A.D., Lincoln S.R, Mahadevan I., Rofe A.M. Measurement of zinc in hepatocytes using a fluorescent probe, Zinquin: relationship to metallothionein and intracellular zinc. Biochem. J. 303:1994;781-786.
10. Coyle R, Philcox J.C., Rofe A.M. Hepatic zinc in metallothionein-null mice following zinc challenge: in vivo and in vitro studies. Biochem. J. 309:1995;25-31.
11. Dudley R.E., Svoboda D.J., Klaassen C.D. Acute exposure to cadmium causes severe liver injury in rats. Toxicol. Appl. Pharmacol. 65:1982;302-313.
12. Eaton D.L., Toal B.F. Evaluation of the Cd/hemoglobin assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66:1982;134-142.
13. Failla M.L., Cousins R.J. Zinc accumulation and metabolism in primary cultures of adult rat liver cells: regulation by glucocorticoids. Biochim. Biophys. Acta. 543:1978;293-304.
14. Goering P.L., Klaassen C.D. Zinc-Induced tolerance to cadmium hepatoxicity. Toxicol. Appl. Pharmacol. 74:1984;299-307.
15. Hamer D.H. Metallothionein. Ann. Rev. Biochem. 55:1986;913-951.
16. Kelley S.L., Basu A., Teicher B.A., Hacker M.P., Hamer D.H., Lazo J.S. Overexpression of metallothionein confers resistance to anticancer drugs. Science. 241:1988;1813-1815.
17. Lakritz L, Plopper C.G., Buckpitt A.R. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples. Anal. Biochem. 247:1997;63-68.
18. Lazo J.S., Kondo Y., Dellapiazza D., Michalska A.E., Choo K.H.A. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270:1995;5506-5510.
19. Liu J., Kershaw W.C., Klaassen C.D. Rat primary hepatocyte cultures are a good model for examining metallothionein-induced tolerance to cadmium toxicity. In Vitro Cell. Dev. Biol. 26:1990;75-79.
20. Liu J., Kershaw W.C., Klaassen C.D. The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture. Toxicol. Appl. Pharmacol. 107:1991;27-34.
21. Liu J., Kershaw W.C., Klaassen C.D. Protective effects of zinc on cultured rat primary hepatocytes to metals with low affinity for metallothionein. J. Toxicol. Environ. Health. 35:1992;52-62.
22. Liu Y., Liti J., Iszard M.B., Andrews G.K., Palmiter R.D., Klaassen C.D. Transgenic mice that overexpress metallothionein-1 are protected from cadmium lethallity and hepatotoxicity. Toxicol. Appl. Pharmacol. 135:1995;222-228.
23. Liu J., Liu Y., Michalska A.E., Choo A.K.H., Klaassen C.D. Distribution and retention of cadmium in metallothionein I and II null mice. Toxicol. Appl. Pharmacol. 136:1996;260-268.
24. Masters B.A, Kelly E.J., Quaife C.J., Brinster R.L., Palmiter R.D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA. 91:1994;584-588.
25. Michalska A., Choo K.H.A. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA. 90:1993;8088-8092.
26. Mishima A., Yamamoto C., Fujiwara Y., Kaji T. Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells. Toxicology. 118:1997;85-92.
27. Naruse I., Hayashi Y. Amelioration of the teratogenicity of cadmium by the metallothionein induced by bismuth nitrate. Teratology. 40:1989;459-465.
28. Pattanaik A., Shaw C.E III, Garvey J., Kraker A.J. Basal metallothionein in tumors: widespread presence of apoprotein. J. Inorg. Biochem. 54:1994;91-105.
29. Petering D.H., Dughish M., Huang M., Kreoski S., Krull S., Lewand D., Munoz A., Ren L., Ventatesh S., Blumenthal S., Shaw C.F. III. Cellular metallothionein: properties of apometallothionein and the comparitive toxicity of Cd2+ and Cd-metallothionein. Klaassen C.D. Metallothionein. IV:1999;459-466 Birkhauser, Basel.
30. Rofe A.M., Williamson D.H. Metabolic effects of vasopressin infusion in the starved rat: reversal of ketonaemia. Biochem. J. 212:1983;231-239.
31. Rofe A.M., Barry E.E., Shelton T.L., Philcox J.C., Coyle P. Paracetamol hepatotoxicity in metallothionein-null mice. Toxicology. 125:1998;131-140.
32. Schroeder J.J., Cousins R.J. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc. Natl. Acad. Sci. USA. 87:1990;3137-3141.
33. Shaikh Z.A., Tang W., Sadovic S. Zinc-induced protection against cadmiummetallothionein nephrotoxicity depends on glutathione status. Klaassen C.D. Metallothionein IV. 1999;467-469 Birkhauser, Basel.
34. Shiraishi N., Barter R.A., Uno H., Waalkes P.P. Effect of progesterone on cadmium toxicity in the male Fischer (F344/NCr) rat. Toxicol. Appl. Pharmacol. 118:1993;113-118.
35. Teitze F. Enzymatic method for the quantitative determination of nanogram amounts of total and oxidised glutathione. Application to mammalian blood and other tissues. Anal. Biochem. 27:1969;502-522.
36. Tukey J.W. Comparing individual means in the analysis of variance. Biometrics. 5:1949;99-114.
37. Waalkes M., Klaassen C.D. Concentration of metallothionein in major organs of rats after administration of various metals. Fundament. Appl. Toxicol. 5:1985;473-477.
38. Wolkowski-Tyl R., Preston S.F. The interaction of cadmium-binding proteins (Cd-bp) and progesterone in cadmium-induced tissue and embryo toxicity. Teratology. 20:1979;341-352.
39. Wong K.L., Klaassen C.D. Relationship between tissue levels of glutathione and metallothionein in rats. Toxicology. 19:1981;39-47.
40. Woo E.S., Lazo J.S. Nucleocytoplasmic functionality of metallothionein. Cancer Res. 57:1997;4236-4241.
41. Zheng R, Liu L, Liu Y., Klaassen C.D. Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity. Toxicol. Lett. 87:1996;139-145.