Discovery of (2S)-1-(4-Amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-pi perazinyl}-2-propanol Dimethanesulfonate (SUN N8075): A dual Na+ and Ca2+ channel blocker with antioxidant activity

Journal of Medicinal Chemistry

Volumn 43, Issue 18, 2000, Pages 3372-3376

  Annoura, H ^a   Nakanishi, K ^a   Toba, T ^a   Takemoto, N ^a   Imajo, S ^a   Miyajima, A ^a   Tamura Horikawa, Y ^a   Tamura, S ^a  

^a SUNTORY LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINO 2,3,5 TRIMETHYLPHENOXY) 3 [4 [4 (4 FLUOROBENZYL)PHENYL] 1 PIPERAZINYL] 2 PROPANOL DIMETHANESULFONATE; 7 [[4 [BIS(4 FLUOROPHENYL)METHYL] 1 PIPERAZINYL]METHYL] 2 [(2 HYDROXYETHYL)AMINO] 4 ISOPROPYL 2,4,6 CYCLOHEPTATRIEN 1 ONE; ALPHA TOCOPHEROL; ANTIOXIDANT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DOPAMINE 2 RECEPTOR; FLUNARIZINE; LIPID; NEUROTOXIN; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SUN N8075; UNCLASSIFIED DRUG; VERATRIDINE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTIOXIDANT ACTIVITY; BINDING AFFINITY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; EXTRAPYRAMIDAL SYMPTOM; HUMAN; LETTER; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; SODIUM CALCIUM EXCHANGE; STRUCTURE ACTIVITY RELATION;

ACOUSTIC STIMULATION; ANILINE COMPOUNDS; ANIMALS; ANTICONVULSANTS; ANTIOXIDANTS; CALCIUM CHANNEL BLOCKERS; CEREBRAL CORTEX; LIPID PEROXIDATION; MICE; MICE, INBRED DBA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUROPROTECTIVE AGENTS; PIPERAZINES; RATS; SEIZURES; SODIUM CHANNEL BLOCKERS;

EID: 0034618546     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000143w     Document Type: Letter

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