-
2
-
-
84981860375
-
-
R. L. Noble, C. T. Beer and J. H. Cutts, Ann. N.Y. Acad. Sci., 1958, 76, 882.
-
(1958)
Ann. N.Y. Acad. Sci.
, vol.76
, pp. 882
-
-
Noble, R.L.1
Beer, C.T.2
Cutts, J.H.3
-
4
-
-
33645929976
-
-
note
-
By binding to the protein tubulin with high affinity, the vinca alkaloids inhibit microtubule assembly (they prevent cells from making the spindles needed to pull the chromosomes apart during cell division). This action is similar to that of colchicine, but is different from that of taxol, which also binds to tubulin but interferes with cell division in an opposite way, by preventing the spindles from being broken down.
-
-
-
-
7
-
-
33645933200
-
-
note
-
(a) An unpublished account of an X-ray structure determination of a different salt of the title compound (vinblastine dihydrochloride) has been mentioned in reference 6(b) as footnote 19 ("O. Kennard and J. Nachman, unpublished observations"), but no details were given other than the fact that the C17′-C18′-C15-C16 dihedral angle in that molecule had a value of 165°
-
-
-
-
8
-
-
37049101965
-
-
(b) B. K. Hunter, L. D. Hall and J. K. M. Sanders, J, Chem. Soc., Perkin Trans. 1, 1983, 657.
-
(1983)
J, Chem. Soc., Perkin Trans. 1
, pp. 657
-
-
Hunter, B.K.1
Hall, L.D.2
Sanders, J.K.M.3
-
9
-
-
0003492872
-
-
eds., A. Ducruix and R. Giegé, Oxford University Press, Oxford, UK
-
(a) Crystallization of Nucleic Acids and Proteins, eds., A. Ducruix and R. Giegé, Oxford University Press, Oxford, UK, 1992
-
(1992)
Crystallization of Nucleic Acids and Proteins
-
-
-
10
-
-
0003772938
-
-
ed. T. M. Bergfors, International University Line Press, Oxford, UK
-
(b) Protein Crystallization: Techniques, Strategies and Tips, ed. T. M. Bergfors, International University Line Press, Oxford, UK, 1999.
-
(1999)
Protein Crystallization: Techniques, Strategies and Tips
-
-
-
13
-
-
0004150157
-
-
University of Göttingen, Germany
-
(a) G. M. Sheldrick, SHELXS-86, University of Göttingen, Germany, 1986
-
(1986)
SHELXS-86
-
-
Sheldrick, G.M.1
-
14
-
-
0004150157
-
-
University of Cambridge, England
-
(b) G. M. Sheldrick, SHELX-76, University of Cambridge, England, 1976.
-
(1976)
SHELX-76
-
-
Sheldrick, G.M.1
-
15
-
-
33749417699
-
-
18 position is inverted (V. M. Lynch, A. Stamford, P. Magnus and B. E. David, Acta Crystallogr., Sect. C, 1991, 47, 1563.
-
(1991)
Acta Crystallogr., Sect. C
, vol.47
, pp. 1563
-
-
Lynch, V.M.1
Stamford, A.2
Magnus, P.3
David, B.E.4
-
16
-
-
0029069884
-
-
C. W. Andrews, J. Wisowaty, A. O. Davis, R. Crouch and G. E. Martin, J. Heterocycl. Chem., 1995, 32, 1011.
-
(1995)
J. Heterocycl. Chem.
, vol.32
, pp. 1011
-
-
Andrews, C.W.1
Wisowaty, J.2
Davis, A.O.3
Crouch, R.4
Martin, G.E.5
-
17
-
-
33645939472
-
-
note
-
5
-
-
-
-
18
-
-
33645954833
-
-
note
-
Peaks corresponding to H positions were found 0.95 Å from N6′ (peak H58) and 1.16 Å from N9 (peak H57). This not only indicates that both nitrogen atoms are protonated, but it also suggests that the hydrogen bond between N9 and the C3 hydroxy group is of the type N9-H ⋯ O27 and not N9 ⋯ H-O27.
-
-
-
-
21
-
-
77957095647
-
-
eds. A. Brossi and M. Suffness, Academic Press, New York
-
(a) M. E. Kuehne and I. Marko, in The Alkaloids, eds. A. Brossi and M. Suffness, Academic Press, New York, 1990, vol. 37, p. 77
-
(1990)
The Alkaloids
, vol.37
, pp. 77
-
-
Kuehne, M.E.1
Marko, I.2
-
22
-
-
0018728587
-
-
(b) P. Potier, D. Guénard and F. Zavala, C. R. Soc. Biol, 1979, 173, 414.
-
(1979)
C. R. Soc. Biol
, vol.173
, pp. 414
-
-
Potier, P.1
Guénard, D.2
Zavala, F.3
-
23
-
-
77957030571
-
-
eds. A. Brossi and M. Suffness, Academic Press, New York
-
(a) L. S. Borman and M. Kuehne, in The Alkaloids, eds. A. Brossi and M. Suffness, Academic Press, New York, 1990, vol. 37, p. 133
-
(1990)
The Alkaloids
, vol.37
, pp. 133
-
-
Borman, L.S.1
Kuehne, M.2
-
24
-
-
0027411538
-
-
(b) L. S. Borman, W. G. Bornmann and M. E. Kuehne, Cancer Chemother. Pharmacol., 1993, 31, 343.
-
(1993)
Cancer Chemother. Pharmacol.
, vol.31
, pp. 343
-
-
Borman, L.S.1
Bornmann, W.G.2
Kuehne, M.E.3
-
25
-
-
0029608861
-
-
J. G. Dong, W. Bornmann, K. Nakanishi and N. Berova, Phytochemistry, 1995, 40, 1821.
-
(1995)
Phytochemistry
, vol.40
, pp. 1821
-
-
Dong, J.G.1
Bornmann, W.2
Nakanishi, K.3
Berova, N.4
-
26
-
-
0026607701
-
-
E. Gageelli, G. Valensin, N. J. Stolowich, H. J. Williams and A. I. Scott, J. Nat. Prod., 1992, 55, 285.
-
(1992)
J. Nat. Prod.
, vol.55
, pp. 285
-
-
Gageelli, E.1
Valensin, G.2
Stolowich, N.J.3
Williams, H.J.4
Scott, A.I.5
-
27
-
-
0023502554
-
-
See reference 3 in: P. Magnus, M. Ladlow and J. Elliott, J. Am. Chem. Soc., 1987, 109, 7929.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 7929
-
-
Magnus, P.1
Ladlow, M.2
Elliott, J.3
-
28
-
-
0032495513
-
-
E. Nogales, S. G. Wolf and K. H. Downing, Nature, 1998, 391, 199.
-
(1998)
Nature
, vol.391
, pp. 199
-
-
Nogales, E.1
Wolf, S.G.2
Downing, K.H.3
|