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Volumn , Issue 13, 2000, Pages 2079-2082

Crystal structure of vinblastine

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFUSION; DRUG PRODUCTS; MOLECULAR STRUCTURE; X RAY CRYSTALLOGRAPHY;

EID: 0034617312     PISSN: 14704358     EISSN: None     Source Type: Journal    
DOI: 10.1039/b001855o     Document Type: Article
Times cited : (22)

References (28)
  • 4
    • 33645929976 scopus 로고    scopus 로고
    • note
    • By binding to the protein tubulin with high affinity, the vinca alkaloids inhibit microtubule assembly (they prevent cells from making the spindles needed to pull the chromosomes apart during cell division). This action is similar to that of colchicine, but is different from that of taxol, which also binds to tubulin but interferes with cell division in an opposite way, by preventing the spindles from being broken down.
  • 7
    • 33645933200 scopus 로고    scopus 로고
    • note
    • (a) An unpublished account of an X-ray structure determination of a different salt of the title compound (vinblastine dihydrochloride) has been mentioned in reference 6(b) as footnote 19 ("O. Kennard and J. Nachman, unpublished observations"), but no details were given other than the fact that the C17′-C18′-C15-C16 dihedral angle in that molecule had a value of 165°
  • 9
    • 0003492872 scopus 로고
    • eds., A. Ducruix and R. Giegé, Oxford University Press, Oxford, UK
    • (a) Crystallization of Nucleic Acids and Proteins, eds., A. Ducruix and R. Giegé, Oxford University Press, Oxford, UK, 1992
    • (1992) Crystallization of Nucleic Acids and Proteins
  • 10
  • 13
    • 0004150157 scopus 로고
    • University of Göttingen, Germany
    • (a) G. M. Sheldrick, SHELXS-86, University of Göttingen, Germany, 1986
    • (1986) SHELXS-86
    • Sheldrick, G.M.1
  • 14
    • 0004150157 scopus 로고
    • University of Cambridge, England
    • (b) G. M. Sheldrick, SHELX-76, University of Cambridge, England, 1976.
    • (1976) SHELX-76
    • Sheldrick, G.M.1
  • 17
    • 33645939472 scopus 로고    scopus 로고
    • note
    • 5
  • 18
    • 33645954833 scopus 로고    scopus 로고
    • note
    • Peaks corresponding to H positions were found 0.95 Å from N6′ (peak H58) and 1.16 Å from N9 (peak H57). This not only indicates that both nitrogen atoms are protonated, but it also suggests that the hydrogen bond between N9 and the C3 hydroxy group is of the type N9-H ⋯ O27 and not N9 ⋯ H-O27.
  • 21
    • 77957095647 scopus 로고
    • eds. A. Brossi and M. Suffness, Academic Press, New York
    • (a) M. E. Kuehne and I. Marko, in The Alkaloids, eds. A. Brossi and M. Suffness, Academic Press, New York, 1990, vol. 37, p. 77
    • (1990) The Alkaloids , vol.37 , pp. 77
    • Kuehne, M.E.1    Marko, I.2
  • 23
    • 77957030571 scopus 로고
    • eds. A. Brossi and M. Suffness, Academic Press, New York
    • (a) L. S. Borman and M. Kuehne, in The Alkaloids, eds. A. Brossi and M. Suffness, Academic Press, New York, 1990, vol. 37, p. 133
    • (1990) The Alkaloids , vol.37 , pp. 133
    • Borman, L.S.1    Kuehne, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.