Microgravity-induced bone loss - Will it limit human space exploration?

Lancet

Volumn 355, Issue 9215, 2000, Pages 1569-1570

  Holick, Michael F ^a  

^a Skin Bone Res Lab Sect E   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL;

BONE ATROPHY; BONE DENSITY; BONE MINERAL; HUMAN; HUMAN TISSUE; MICROGRAVITY; NOTE; PRIORITY JOURNAL;

EID: 0034612096     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(80)02208-8     Document Type: Note

References (11)

1. Holick M.F. Perspective on the impact of weightlessness on calcium and bone metabolism. Bone. 22:1998;105-111.
2. Parfitt A.M. Bone effect of space flight. analysis by quantum concept of bone remodeling Acta Astronaut. 8:1981;1083-1090.
3. Whedon G.D., Lutwak L., Reid J.et al. Mineral and nitrogen metabolic studies on Skylab orbital space flights. Trans Assoc Am Physicians. 87:1974;95-110.
4. Stupakov G.P., Kazeikin V.S., Kozlovskii A.P., Korolev V.V. Evaluation of the changes in the bone structures of the human axial skeleton in prolonged space flight. Kosm Biol Aviakosm Med. 18:1984;33-37. [in Russian].
5. LeBlanc A.D., Schneider F.S., Evans H.J., Engelbretson D.A., Krebs J.M. Bone mineral loss and recovery after 17 weeks of bed-rest. J Bone Miner Res. 5:1990;843-850.
6. Arnaud S.B., Sherrard D.J., Maloney N., Whalen R.T., Fung P. Effect of 1 week head-down tilt bed-rest on bone formation and the calcium endocrine system. Aviat Space Environ Med. 52:1991;1-7.
7. Lueken S.A., Arnaud S.B., Taylor A.K., Baylink D.J. Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res. 8:1993;1433-1438.
8. Schneider V.S., McDonald J. Skeletal calcium homeostasis and countermeasures to prevent disuse osteoporosis. Calcif Tissue Int. 36:1984;151-154.
9. Lockwood D.R., Vogel J.M., Schneider V.S., Hulley S.B. Effect of the diphosphonate EHDP on bone mineral metabolism during prolonged bed rest. J Endocrinol Metab. 41:1990;533-541.
10. Tilton F.E., Gegioanni J.J.C., Schneider F.S. Long-term follow-up of Skylab bone demineralization. Aviat Space Environ Med. 51:1980;1209-1213.
11. Slovik D.M., Rosenthal D.I., Doppelt S.H.et al. Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1-34) and 1, 25-dihydroxyvitamin D. J Bone Miner Res. 1:1986;377-381.