A method for the one-pot regioselective formation of the two disulfide bonds of α-conotoxin SI

Tetrahedron Letters

Volumn 41, Issue 19, 2000, Pages 3661-3663

  Cuthbertson, Alan ^a   Indrevoll, Bård ^a  

^a NYCOMED IMAGING AS   (Norway)

Author keywords

Disulfides; Peptide; Protecting groups; Regioselection

Indexed keywords

CONOTOXIN;

ARTICLE; CHEMICAL REACTION; DISULFIDE BOND; DRUG STRUCTURE; DRUG SYNTHESIS; OXIDATION; REACTION ANALYSIS; STEREOCHEMISTRY; TEMPERATURE;

EID: 0034612064     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00437-8     Document Type: Article

References (11)

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8. Atherton, E.; Sheppard, R. C. Solid Phase Synthesis; IRL Press: Oxford, 1989.
9. HPLC co-elution: Product 2 and an authentic sample of α-conotoxin SI (Bachem) were co-injected on a Vydac 218TP54 analytical column. The peptide was eluted using a gradient of 0 to 30% B over 40 min where A=water/0.1% TFA and B=acetonitrile/0.1% TFA at a flow rate of 1 mL/min. The product was a single peak with a retention time of 28.3 min.
10. Hargittai, B.; Barany, G. J. Peptide Res. 1999, 54, 468-479.
11. +.