Solid-phase synthesis of aryl ethers on high loading dendrimer resin

Tetrahedron Letters

Volumn 41, Issue 19, 2000, Pages 3763-3767

  Basso, Andrea ^a   Evans, Brian ^b   Pegg, Neil ^b   Bradley, Mark ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Dendrimers; High loading beads; Single bead screening; Solid phase synthesis

Indexed keywords

DENDRIMER; ETHER DERIVATIVE; RESIN;

ARTICLE; DERIVATIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLYMERIZATION; REACTION ANALYSIS; REACTION TIME; SYNTHESIS;

EID: 0034612039     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00479-2     Document Type: Article

References (12)

1. Furka, A.; Sebestyen, F.; Asgedom, M.; Dibo, G. Abstr. 14th Int. Congr. Biochem., Prague, Czechoslovakia 1988, 5, 47; Abstr. 10th Int. Symp. Med. Chem. 1988, Budapest, Hungary, 288.
2. Furka, A.; Sebestyen, F.; Asgedom, M.; Dibo, G. Abstr. 14th Int. Congr. Biochem., Prague, Czechoslovakia 1988, 5, 47; Abstr. 10th Int. Symp. Med. Chem. 1988, Budapest, Hungary, 288.
3. Lebl, M.; Krchnák, V.; Sepetov, N. F.; Seligmann, B.; Strop, P.; Felder, S.; Lam, K. S. Biopolymers (Peptide Science) 1995, 37, 177-198.
4. Swali, V.; Wells, N. J.; Langley, G. J.; Bradley, M. J. Am. Chem. Soc. 1997, 62, 4902-4903.
5. Wells, N. J.; Basso, A.; Bradley, M. Biopolymers (Peptide Science) 1998, 47, 381-396.
6. Sarin, V. K.; Kent, S. B. H.; Tam, J. P.; Merrifield, R. B. Anal. Biochem. 1981, 117, 147-157.
7. Chang, C. D.; Waki, M.; Ahmad, M.; Meienhofer, J.; Lundell, E. O.; Haug, J. D. Int. J. Pept. Protein Res. 1980, 15, 59-66.
8. Mitsunobu, O. Synthesis 1981, 1-28.
9. Rano, T. A.; Chapman, K. T. Tetrahedron Lett. 1995, 36, 3789-3792.
10. Tsunoda, T.; Otsuka, J.; Yamamiya, Y.; Ito, S. Chem. Lett. 1994, 539-542.
11. Richter, L. S.; Gadek, T. R. Tetrahedron Lett. 1994, 35, 4705-4706.
12. 1H NMR signal integrations. This is then used as an internal standard in the calculation of the quantity of compound released by a known amount of resin.