Asymmetric synthesis of (2S,4R)-4-hydroxypipecolic acid

Tetrahedron Letters

Volumn 41, Issue 19, 2000, Pages 3551-3553

  Brooks, Clinton A ^a   Comins, Daniel L ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Amino acids; Asymmetric synthesis; Dihydropyridones; Pyridinium salts

Indexed keywords

ANTIVIRUS AGENT; PALINAVIR; PIPECOLIC ACID DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

EID: 0034611961     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00460-3     Document Type: Article

References (15)

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10. Comins, D. L.; Joseph, S. P.; Goehring, R. R. J. Am. Chem. Soc. 1994, 116, 4719.
11. TCC=trans-2-(α-cumyl)cyclohexanol, see: Comins, D. L.; Salvador, J. M. J. Org. Chem. 1993, 58, 4656.
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13. The racemic compound is known, see: Hays, S. J.; Malone, T. C.; Johnson, G. J. Org. Chem. 1991, 56, 4084.
14. 13C NMR spectra and elemental analysis or high-resolution mass spectra.
15. 3) δ 205.2, 170.8, 155.8, 136.2, 135.2, 128.9, 128.8, 128.5, 128.4, 128.2, 68.2, 67.7, 54.8, 41.3, 40.5, 39.8.