The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 5, 2000, Pages 483-486

  Milkiewicz, Karen L ^a   Marsilje, Thomas H ^a,b   Woodworth, Richard P ^a   Bifulco, Neil ^a   Hangauer, Matthew J ^a   Hangauer, David G ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYDROXYINDOLE AMIDE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE P60; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INHIBITION KINETICS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDOLES; MODELS, MOLECULAR; SRC-FAMILY KINASES;

EID: 0034611235     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00040-8     Document Type: Article

References (9)

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9. The % inhibition was 46% and 41% with 2k at 45 μM and [ATP] at 200 or 1000 μM, respectively.