Synthesis and cytotoxicity of 4-amino-5-oxopyrido[2,3-d]pyrimidine nucleosides

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3704-3713

  Girardet, J L ^a   Gunic, E ^a   Esler, C ^a   Cieslak, D ^a   Pietrzkowski, Z ^a   Wang, G ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 CYANO 4 METHOXYPYRIDINE; 4 AMINO 5 OXO 8 (BETA RIBOFURANOSYL)PYRIDO[2,3 D]PYRIMIDINE; 4 AMINO 5 OXO 8 (BETA XYLOFURANOSYL)PYRIDO[2,3 D]PYRIMIDINE; 4 AMINO 5 OXOPYRIDO[2,3 D]PYRIMIDINE; 4 AMINO 5 OXOPYRIDO[2,3 D]PYRIMIDINE NUCLEOSIDE DERIVATIVE; CARBOHYDRATE DERIVATIVE; NUCLEOSIDE ANALOG; NUCLEOSIDE DERIVATIVE; PYRIDO[2,3 D]PYRIMIDINE NUCLEOSIDE; PYRIMIDINE DERIVATIVE; SANGIVAMYCIN DERIVATIVE; TOYOCAMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG INDUCED DISEASE; FIBROBLAST; HUMAN; HUMAN CELL; MELANOMA; PROSTATE CARCINOMA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; MICE; NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0034609860     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000073t     Document Type: Article

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