Synthesis and hypolipidemic and antiplatelet activities of α-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo)

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3671-3676

  Poplawski, J ^a   Lozowicka, B ^a   Dubis, A T ^a   Lachowska, B ^a   Witkowski, S ^a   Siluk, D ^b   Petrusewicz, J ^b   Kaliszan, R ^b   Cybulski, J ^c   Strzalkowska, M ^c   Chilmonczyk, Z ^d  

^a UNIVERSITY OF BIALYSTOK   (Poland)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

^d NATIONAL MEDICINES INSTITUTE   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ASARONE; CLOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INDOMETACIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPOLIPEMIA; ISOMER; LIPOPROTEIN BLOOD LEVEL; LUNG EMBOLISM; MOUSE; NONHUMAN; RAT; STRUCTURE ANALYSIS; THROMBOCYTE AGGREGATION;

ANIMALS; ANISOLES; ANTILIPEMIC AGENTS; FIBRINOLYTIC AGENTS; HUMANS; LUNG; MALE; MICE; PLATELET AGGREGATION; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOEMBOLISM;

EID: 0034609856     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000905n     Document Type: Article

References (34)

1. The pathogenesis of atherosclerosis - An update
2. Khellin analogues. 1. General topological requirements for lipid-altering activity in furochromones
3. The HDL: The good cholesterol carriers?
4. Thromboembolic diseases: Biochemical mechanisms and new possibilities of biological diagnosis
5. Insights into the pathogenesis of acute ischemic syndromes
6. Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis
7. Ischaemic heart disease and platelet aggregation
8. Antiplatelet drugs
9. Current trends in antithrombotic drug and device development
10. Antiaggregatory effects of flavonoids in vivo and their influence on lipooxygenase and cyclooxygenase in vitro
11. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins
12. Analytische und biopharmazeutische Untersuchung transisoasaronhaltiger Preparate
13. Asarone and its biological properties
14. Synthesis (E) and (Z)-asarones and its analogues
15. Inhibition of lipid synthesis and secretion in long-term culture of adult rat hepatocytes by α-asarone
16. Propenylbenzenes from Guatteria guameri
17. Synthesis and hypolipidemic activity of some α-asarone analogues
18. Effet de l' α-asarone sur l'hypercholesterolemie et la cholelithiasis experimentales
19. The mechanism of the tranquilizing action of asarone from Acorus Calamus Linn
20. Mobility inhibition and nematocidal activity of asarone and related phenylpropanoids on second-stage larvae of Toxocara canis
21. Teratogenic action of alpha-asarone in the mouse
22. Pharmacology and toxicology of Gatteria Guameri and alpha-asarone
23. Dibenzofuran. XXI. Benzene and Biphenyl Intermediates for 1,9-Derivatives
24. The six trimethoxyphenylisopropylamines (Trimethoxyamphetamines)
25. Comparative studies of antiplatelet activity of nonsteroidal antiinflammatory drugs and new pyrazine CH- and NH-acids
26. The hypolipidemic activity of alkylamines and their boranes derivatives: Structure-activity relationship in rodents
27. High-density lipoprotein: Are elevated levels desirable and achievable?
28. Postprandial lipoprotein responses in hypertriglyceridemic subjects with and without cardiovascular disease
29. Hypolipidemic activity of α-asarone in mice
30. Pharmacodynamics and Pharmacokinetics of Ticlopidine
31. Novel synthesis of 2,3,4-trimethoxy-1-propenylbenzene
32. Mouse antithrombotic assay: A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by alcohol
33. Aggregation of blood platelets by adenosine diphosphate and its reversal