New substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with α2-adrenoceptor antagonist activity

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3653-3664

  Mayer, P ^a   Brunel, P ^a   Chaplain, C ^a   Piedecoq, C ^a   Calmel, F ^a   Schambel, P ^a   Chopin, P ^a   Wurch, T ^a   Pauwels, P J ^a   Marien, M ^a   Vidaluc, J L ^a   Imbert, T ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2,3 DIHYDROBENZO[1,4]DIOXIN 2 YLMETHYL]PIPERIDIN 4 YL; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; AMIDE; ATIPAMEZOLE; CLONIDINE; DOPAMINE 2 RECEPTOR; EFAROXAN; FLUPAROXAN; IDAZOXAN; IMIDAZOLINE; PIPEROXAN; R 47243; UNCLASSIFIED DRUG; UREA; YOHIMBINE;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PARKINSON DISEASE; STRUCTURE ANALYSIS;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; DIOXANES; GUANABENZ; HYPOTHERMIA; IMIDAZOLES; MALE; MEMBRANES; MICE; NEUROGLIA; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034609811     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991121g     Document Type: Article

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