Design, synthesis, and SAR of novel carbapenem antibiotics with high stability to Xanthomonas maltophilia oxyiminocephalosporinase type II

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3632-3640

  Hakimelahi, G H ^a   Moosavi Movahedi, A A ^c   Tsay, S C ^a   Tsai, F Y ^a,d   Wright, J D ^b   Dudev, T ^b   Hakimelahi, S ^b,e   Lim, C ^b,d  

^a INSTITUTE OF CHEMISTRY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c UNIVERSITY OF TEHRAN   (Iran)

^d NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETOXYETHYL 6 (PHENYLACETAMIDO)CARBAPENEM; 2 HYDROXYCARBONYL 6 (PHENYLACETAMIDO)CARBAPENEM; 2 HYDROXYETHYL 6 (PHENYLACETAMIDO)CARBAPENEM; 2 METHOXYCARBOMETHYL 6 (PHENYLACETAMIDO)CARBAPENEM; 2 METHOXYCARBONYL 6 (PHENYLACETAMIDO)CARBAPENEM; 6 (PHENYLACETAMIDO)CARBAPENEM; BACTERIAL ENZYME; BETA LACTAMASE; CARBAPENEM DERIVATIVE; IMIPENEM; OXYIMINOCEPHALOSPORINASE II; PENICILLIN G; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DEHYDRATION; DRUG DESIGN; DRUG POTENCY; DRUG POTENTIATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION;

BETA-LACTAMASES; CARBAPENEMS; COLONY COUNT, MICROBIAL; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; STENOTROPHOMONAS MALTOPHILIA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034609810     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000213z     Document Type: Article

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