A novel strategy for designing irreversible inhibitors of metalloproteases: Acetals as latent electrophiles that interact with catalytic nucleophile at the active site

Organic Letters

Volumn 2, Issue 20, 2000, Pages 3149-3152

  Han, Min Su ^a   Ryu, Choon Ho ^a   Chung, Sang J ^a   Kim, Dong H ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKANE; CARBOXYPEPTIDASE; CARBOXYPEPTIDASE A; METALLOPROTEINASE; PROTEINASE INHIBITOR; VALERIC ACID DERIVATIVE;

ARTICLE; BINDING SITE; CATALYSIS; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; KINETICS; STEREOISOMERISM; SYNTHESIS;

ALKANES; BINDING SITES; CARBOXYPEPTIDASES; CARBOXYPEPTIDASES A; CATALYSIS; DRUG DESIGN; KINETICS; METALLOENDOPEPTIDASES; PENTANOIC ACIDS; PROTEASE INHIBITORS; STEREOISOMERISM;

EID: 0034609676     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol006346w     Document Type: Article

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