Comparative genomic hybridization: A new approach to screening for intrauterine complete or mosaic aneuploidy

American Journal of Medical Genetics

Volumn 92, Issue 4, 2000, Pages 281-284

  Lestou, V S ^a   Desilets, V ^a   Lomax, B L ^a   Barrett, I J ^a   Wilson, R D ^a   Langlois, S ^a   Kalousek, D K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CGH of placental tissue; Confined placental mosaicism; Extraembryonic tissues; Intrauterine chromosomal mosaicism

Indexed keywords

AMNION FLUID; ANEUPLOIDY; ARTICLE; CHROMOSOME MOSAICISM; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN TISSUE; INFANT; MALE; PLACENTA; PRIORITY JOURNAL; STROMA; TRISOMY; TROPHOBLAST;

AMNION; ANEUPLOIDY; CHROMOSOME ABERRATIONS; DNA; FEMALE; GENETIC SCREENING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MOSAICISM; NUCLEIC ACID HYBRIDIZATION; PLACENTA; PREGNANCY; TROPHOBLASTS; UTERUS;

EID: 0034608277     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000605)92:4<281::AID-AJMG12>3.0.CO;2-S     Document Type: Article

References (12)

1. Barker DJP. 1997. The long term outcome of retarded fetal growth. Clin Obstet Gynecol 40:853-863.
2. Breen CJ, Barton L, Carey A, Dunlop A, Glancy M, Hall K, Hegarty AM, Khokhar MT, Power M, Ryan K, Green AJ, Stallings RL. 1999. Applications of comparative genomic hybridization in constitutional chromosome studies. J Med Genet 36:511-517.
3. Hassold T, Hunt PA, Sherman S. 1993. Trisomy in humans: incidence, origin and etiology. Curr Opin Genet Dev 3:398-403.
4. Henderson KG, Shaw TE, Barrett IJ, Telenius AHP, Wilson RD, Kalousek DK. 1996. Distribution of mosaicism in human placentas. Hum Genet 97:650-654.
5. Jacobs PA, Hassold TJ. 1987. Chromosome abnormalities: origin and etiology in abortions and livebirths. In: Vogel F, Sperling K, editors. Human genetics. Berlin: Springer-Verlag, p 233-244.
6. Kallioniemi OP, Kallioniemi A, Piper J, Isola J, Waldman F, Gray JW, Pinkel D. 1994. Optimizing comparative genomic hybridization for analysis of DNA sequence copy changes in solid tumors. Genes Chromosome Cancer 10:231-234.
7. Kalousek DK. 1993. The effect of confined placental mosaicism on development of the human aneuploid conceptus. Birth Def 29:39-51.
8. Kalousek DK, Robinson W, Harrington B, Lestou VS. 1998. Molecular biology of the placenta with focus on special placental studies of infants with intrauterine growth retardation. In: Lewis SH, Perrin E, editors. Pathology of the placenta. Philadelphia: Churchill Livingstone. p 343-365.
9. Lestou VS, Kalousek DK. 1998. Confined placental mosaicism and intra-uterine fetal growth. Arch Dis Child Fetal Neonat Ed 79:223-226.
10. Lestou VS, Lomax BL, Barrett IJ, Kalousek DK. 1999. Screening of human placentas for chromosomal mosaicism using comparative genomic hybridization. Teratology 59:325-330.
11. Lomax BL, Tang SS, Separovic E, Thomson T, Kalousek DK. 1999. Comparative genomic hybridization (CGH) in combination with flow cytometry improves the accuracy of cytogenetic analysis of spontaneous abortions. Am J Hum Genet (in press).
12. Warburton D. 1999. Comparative genomic hybridization: FISH and chips in our future? Teratology 59:321-322.