Identification of immunogenic antigens of Helicobacter pylori via the Escherichia coli hemolysin secretion system

FEMS Microbiology Letters

Volumn 186, Issue 2, 2000, Pages 251-256

  Spreng, Simone ^a   Gentschev, Ivaylo ^a   Goebel, Werner ^a   Mollenkopf, Hans Joachim ^a   Eck, Mathias ^b   Müller Hermelink, Hans Konrad ^b   Schmausser, Bernd ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Escherichia coli hemolysin; Helicobacter pylori antigen; Secretion of hlyA fusion protein

Indexed keywords

BACTERIAL ANTIGEN; HEMOLYSIN; HYBRID PROTEIN;

ARTICLE; BACTERIAL GENE; CHRONIC GASTRITIS; CONTROLLED STUDY; DNA SEQUENCE; ESCHERICHIA COLI; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOGENICITY; MOLECULAR CLONING; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN SECRETION; RECOMBINANT PLASMID; SERUM; STOMACH CARCINOMA;

ESCHERICHIA COLI; HELICOBACTER PYLORI;

EID: 0034607791     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(00)00157-9     Document Type: Article

References (27)

1. Alm R.A., Ling L.S., Moir D.T., King B.L., Brown E.D., Doig P.C., Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 397:1999;176-180.
2. Blaser M.L., Perez-Perez G.L., Kleanthous H., Cover T.L., Peek R.M., Chyou P.H., Stemmermann G.N., Nomura A. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55:1995;2111-2115.
3. Blight M.A., Holland J.B. Heterologous protein secretion and the versatile Escherichia coli haemolysin translocator. Trends Biotechnol. 12:1994;450-455.
4. Braun V., Killmann H. Bacterial solutions to the iron-supply problem. Trends Biochem. Sci. 24:1999;104-109.
5. Censini S., Lange C., Xiang Z., Crabtree J.E., Ghiara P., Borodovsky M., Rappuoli R., Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA. 93:1996;14648-14653.
6. Crabtree J.E., Taylor J.D., Wyatt J.I., Heatley R.V., Shallcross T.M., Tompkins D.S., Rathbone B.J. Mucosal recognition of Helicobacter pylori 120 kda protein, peptic ulceration, and gastric pathology. Lancet. 338:1991;332-335.
7. Eck M., Schmaußer B., Haas R., Greiner A., Czub S., Müller-Hermelink H.K. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein. Gastroenterology. 112:1997;1482-1486.
8. Foreman D. Eurogast Study Group. An international association between Helicobacter pylori infection and gastric cancer. Lancet. 341:1993;359-362.
9. Gentschev I., Mollenkopf H.-J., Sokolovic Z., Ludwig A., Tengel C., Hess J., Demuth A., Goebel W. Synthesis and secretion of bacterial antigens by attenuated Salmonella via the Escherichia coli hemolysin secretion system. Behring Inst. Mitt. 95:1994;57-66.
10. Gentschev I., Mollenkopf H.-J., Sokolovic Z., Hess J., Kaufmann S.H.E., Goebel W. Development of antigen-delivery systems, based on the Escherichia coli hemolysin secretion pathway. Gene. 179:1996;133-140.
11. Gentschev I., Dietrich G., Mollenkopf H.-J., Sokolovic Z., Hess J., Kaufmann S.H.E., Goebel W. The Escherichia coli hemolysin secretion apparatus - a versatile antigen delivery system in attenuated Salmonella. Behring Inst. Mitt. 98:1997;103-113.
12. Greiner A., Müller-Hermelink H.K. Recent advances in gastric extranodal B-cell lymphoma. Curr. Diagn. Pathol. 3:1996;91-98.
13. Hess J., Wels W., Vogel M., Goebel W. Nucleotide sequence of a plasmid-encoded hemolysin determinant and its comparison with a corresponding chromosomal hemolysin sequence. FEMS Lett. 34:1986;1-11.
14. Hess J., Gentschev I., Goebel W., Jarchau T. Analysis of the haemolysin secretion system by PhoA-HlyA fusion proteins. Mol. Gen. Genet. 224:1990;201-208.
15. Hueck C.J. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 62:1998;379-433.
16. Jarchau T., Chakraborty T., Garcia F., Goebel W. Selection for transport competence of C-terminal polypeptides derived from Escherichia coli hemolysin: the shortest peptide capable of autonomous HlyB-HlyD-dependent secretion comprises the C-terminal 62 amino acids of HlyA. Mol. Gen. Genet. 245:1994;53-60.
17. Kimmel B., Bosserhoff A., Frank R., Gross R., Goebel W., Beier D. Identification of immunodominant antigens from Helicobacter pylori and evaluation of their reactivities with sera from patients with different gastroduodenal pathologies. Infect. Immun. 68:2000;915-920.
18. Lauren F. The two histological main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histoclinical classification. Acta Pathol. Microbiol. Scand. 64:1965;31-40.
19. Mackman N., Baker K., Gray L., Haigh R., Nicaud J.M., Holland I.B. Release of a chimeric protein into the medium from Escherichia coli using the C-terminal secretion signal of haemolysin. EMBO J. 6:1987;2835-2841.
20. McGee D.J., Mobley H.L. Mechanisms of Helicobacter pylori infection: bacterial factors. Curr. Top. Microbiol. Immunol. 241:1999;155-180.
21. Misiewicz J.J., Tytgat G.N.J., Goodwin C.S., et al. The Sydney System: a new classification of gastritis. Work. Party Rep. 1990:1990;1-10.
22. Mollenkopf H.J., Gentschev I., Goebel W. Conversion of bacterial gene products to secretion-competent fusion proteins. BioTechniques. 854:1996;856-860.
23. Spreng S., Gentschev I. Construction of chromosomally encoded secreted hemolysin fusion proteins by use of mini-TnhlyAs transposon. FEMS Microbiol. Lett. 165:1998;187-192.
24. Spreng S., Dietrich G., Goebel W., Gentschev I. The Escherichia coli haemolysin secretion apparatus: a potential universal antigen delivery system in gram-negative bacterial vaccine carriers. Mol. Microbiol. 31:1999;1596-1598.
25. Wagner W., Vogel M., Goebel W. Transport of hemolysin across the outer membrane of Escherichia coli requires two functions. J. Bacteriol. 154:1983;200-210.
26. Wandersman C., Delepelaire P. TolC, an Escherichia coli outer membrane protein required for hemolysin secretion. Proc. Natl. Acad. Sci. USA. 78:1990;4776-4780.
27. Wotherspoon A.C., Ortiz-Hidalgo C., Falzon M.R., Isaacson P.G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 338:1991;1175-1176.