GABAB-ergic modulation of burst rate and intersegmental coordination in lamprey: Experiments and simulations

Brain Research

Volumn 864, Issue 1, 2000, Pages 81-86

  Tegnér, Jesper ^a,b,c   Grillner, Sten ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^c BRANDEIS UNIVERSITY   (United States)

Author keywords

Afterhyperpolarization; Calcium channels; Intersegmental coordination; Motor control; NMDA; Phase lag

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID;

4 AMINOBUTYRIC ACID RELEASE; AFTERHYPERPOLARIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; COMPUTER SIMULATION; CONTROLLED STUDY; LAMPREY; LOCOMOTION; MOTOR CONTROL; MOTOR COORDINATION; NERVE CELL NETWORK; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SPIKE; SPINAL CORD;

ACTION POTENTIALS; ANIMALS; BACLOFEN; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; LAMPREYS; MODELS, NEUROLOGICAL; N-METHYLASPARTATE; NERVE NET; NEURAL PATHWAYS; NEURONS; POTASSIUM CHANNELS; RECEPTORS, GABA-B; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; TIME FACTORS;

EID: 0034607586     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02139-9     Document Type: Article

References (44)

1. B receptor-mediated phasic modulation in axons of spinal motor interneurons, Eur. J. Neurosci. 3 (1991) 107-117.
2. B receptors and coupled G-proteins in spinal GABA-ergic presynaptic inhibition, J. Neurosci. 12 (1991) 3718-3728.
3. B.J. Bacskai, P. Wallén, V. Lev-Ram, S. Grillner, R.Y. Tsien, Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy, Neuron 14 (1995) 19-28.
4. N.G. Bowery, D.R. Hill, A.L. Hudson, A. Doble, D.N. Middlemiss, J. Shaw, M. Turnbull, (-)-baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor, Nature (Lond.) 283 (1980) 92-94.
5. L. Brodin, S. Grillner, C.M. Rovainen, N-methyl-D-aspartate (NMDA), kainate and quisqualate receptors and the generation of fictive locomotion in the lamprey spinal cord, Brain Res. 325 (1985) 302-306.
6. L. Brodin, H. Tråvén, A. Lansner, P. Wallén, Ö. Ekeberg, S. Grillner, Computer simulations of N-methyl-D-aspartate (NMDA) receptor induced membrane properties in a neuron model, J. Neurophysiol. 66 (1991) 473-484.
7. J. Buchanan, Electrophysiological properties of identified classes of lamprey spinal neurons, J. Neurophysiol. 70 (1993) 2313-2325.
8. J. Buchanan, S. Grillner, Newly identified 'glutamate interneurons' and their role in locomotion in the lamprey spinal cord, Science 236 (1987) 312-314.
9. J.T. Buchanan, Identification of interneurons with contralateral, caudal axons in the lamprey spinal cord: Synaptic interactions and morphology, J. Neurophysiol. 47 (1982) 961-975.
10. A.H. Cohen, P.J. Holmes, R.H. Rand, The nature of the coupling between segmental oscillators of the lamprey spinal generator for locomotion: A mathematical model, J. Math. Biol. 13 (1982) 345369.
11. A.H. Cohen, P. Wallén, The neuronal correlate of locomotion in fish. 'Fictive swimming' induced in an in vitro preparation of the lamprey spinal cord, Exp. Brain Res. 41 (1980) 11-18.
12. P. Ekeberg Ö. Hammarlund, B. Levin, A. Lansner, SWIM. A simulation environment for realistic neural network modeling, in: J. Skrzypek (Ed.), Neural Network Simulation Environments, Kluwer, Hingham, MA, 1994, pp. 47-71.
13. Ö. Ekeberg, P. Wallén, A. Lansner, H. Tråvén, L. Brodin, S. Grillner, A computer based model for realistic simulations of neural networks. I. The single neuron and synaptic interaction, Biol. Cybern. 65 (1991) 81-90.
14. A. El Manira, J. Tegnér, S. Grillner, Calcium-dependent potassium channels play a critical role for burst termination in the locomotor network in lamprey, J. Neurophysiol. 72 (1994) 1852-1861.
15. S. Grillner, J. Buchanan, A. Lansner, Simulations of the segmental burst generating network for locomotion in lamprey, Neurosci. Lett. 89 (1988) 31-35.
16. S. Grillner, Ö. Ekeberg, A. El Manira, R. Hill, A. Lansner, D. Parker, J. Tegnér, P. Wallén, Intrinsic function of a neural network - a vertebrate central pattern generator, Brain Res. Rev. 26 (1998) 184-197.
17. S. Grillner, A.D. McClellan, K. Sigvardt, P. Wallén, M. Wilén, Activation of NMDA receptors elicits 'fictive locomotion' in lamprey spinal cord in vitro, Acta Physiol. Scand. 113 (1981) 549-551.
18. S. Grillner, P. Wallén, L. Brodin, A. Lansner, Neuronal network generating locomotor behavior in lamprey: Circuitry, transmitters, membrane properties and simulations, Annu. Rev. Neurosci. 14 (1991) 169-199.
19. B. Gustafsson, Afterhyperpolarization and the control of repetitive firing in spinal neurones of the cat, Acta Physiol. Scand. 416 (1974) 1-47.
20. J. Hellgren, S. Grillner, A. Lansner, Computer simulation of the segmental neural network generating locomotion in lamprey by using populations of network interneurons, Biol. Cybern. 68 (1992) 1-13.
21. R. Hill, T. Matsushima, J. Schotland, S. Grillner, Apamin blocks the slow AHP in lamprey and delays termination of locomotor bursts, NeuroReport 10 (1992) 943-945.
22. A.L. Hodgkin, A.F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol. 117 (1952) 500-544.
23. P. Katz, W. Frost, Intrinsic neuromodulation: Altering neuronal circuits from within, Trends Neurosci. 19 (1996) 54-61.
24. C. Koch, I. Segev, Methods in Neuronal Modeling, From Ions To Networks, MIT Press, Cambridge, MA, 1998.
25. N. Kopell, Toward a theory of modelling central pattern generators, in: A.H. Cohen, S. Rossignol, S. Grillner (Eds.), Neural Control of Rhythmic Movements in Vertebrates, Wiley, New York, 1988, pp. 369-413.
26. N. Kopell, Chains of coupled oscillators, in: A. Arbib (Ed.), The Handbook of Brain Theory and Neural Networks, MIT Press, Cambridge. MA, 1995, pp. 178-183.
27. E. Marder, R.L. Calabrese, Principles of rhythmic motor pattern generation, Physiol. Rev. 76 (1996) 687-717.
28. T. Matsushima, S. Grillner, Neural mechanisms of intersegmental coordination in lamprey: Local excitability changes modify the phase coupling along the spinal cord, J. Neurophysiol. 67 (1992) 373-388.
29. 2 currents, postinhibitory rebound, and postspike afterhyperpo-larization in lamprey neurons, J. Neurophysiol. 70 (1993) 2606-2619.
30. D. Meer, J. Buchanan, Apamin reduces the late afterhyperpolarization of lamprey spinal neurons, with little effect on fictive swimming, Neurosci. Lett. 143 (1992) 1-4.
31. W. Rall, Core conductor theory and cable properties of neurons, in: M. Brookhart, V. Mountcastle, E. Kandel (Eds.), Cellular Biology of Neurons, Handbook of Physiology. The Nervous System, Vol. I, American Physiological Society, Bethesda, MD, 1977, pp. 39-97, Sect. 1.
32. C.M. Rovainen, Synaptic interactions of identified nerve cells in the spinal cord of the sea lamprey, J. Neurophysiol. 154 (1974) 207-223.
33. C.M. Rovainen, Neurophysiology, in: M.W. Hardisty, I.C. Potter (Eds.), The Biology of Lampreys, Academic Press, London, 1983, pp. 1-136, Chapter 30.
34. B-ergic modulation of calcium channels and calcium dependent potassium channels in lamprey as revealed by experiments and simulations, J. Neurophysiol. 81 (1999) 1318-1329.
35. J. Tegnér, J. Hellgren-Kotaleski, A. Lansner, S. Grillner, Low voltage activated calcium channels in the lamprey locomotor network-simulation and experiment, J. Neurophysiol. 77 (1997) 1795-1812.
36. J. Tegnér, A. Lansner, S. Grillner, Modulation of burst frequency by calcium-dependent potassium channels in the lamprey locomotor system-dependence of the activity level, J. Comp. Neurosci. 5 (1998) 121-140.
37. B receptors, J. Neurophysiol. 69 (1993) 647-657.
38. H. Tråvén, L. Brodin, A. Lansner, Ö. Ekeberg, P. Wallén, S. Grillner, Computer simulations of NMDA and non-NMDA receptormediated synaptic drive - sensory and supraspinal modulation of neurons and small networks, J. Neurophysiol. 70 (1993) 695-709.
39. T. Wadden, J. Hellgren-Kotaleski, A. Lansner, S. Grillner, Intersegmental coordination in the lamprey: Simulations using a network model without segmental boundaries, Biol. Cybern. 76 (1997) 1-9.
40. P. Wallén, J. Buchanan, S. Grillner, R. Hill, J. Christenson, T. Hökfelt, Effects of 5-hydroxytryptamine on the afterhyperpolarization, spike frequency regulation, and oscillatory membrane properties in lamprey spinal cord neurons, J. Neurophysiol. 61 (1989) 759-768.
41. P. Wallén, Ö. Ekeberg, A. Lansner, L. Brodin, H. Tråvén, S. Grillner, A computer-based model for realistic simulations of neural networks. II. The segmental network generating locomotor rhythmicity in the lamprey, J. Neurophysiol. 68 (1992) 1939-1950.
42. P. Wallén, S. Grillner, N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey, J. Neurosci. 7 (1987) 2745-2755.
43. M. Wikström, A. El Manira, Calcium influx through N-type and P/Q-type channels activate apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarizarion in lamprey spinal neurons, Eur. J. Neurosci. 10 (1998) 1528-1532.
44. T. Williams, K. Sigvardt, Intersegmental phase lags in the lamprey spinal cord: Experimental confirmation of the existence of a boundary region, J. Comp. Neurosci. 1 (1994) 61-67.