Performance modeling and simulation of biochemical process sequences with interacting unit operations

Biotechnology and Bioengineering

Volumn 67, Issue 3, 2000, Pages 300-311

  Groep, M E ^a,b   Gregory, M E ^b   Kershenbaum, L S ^a   Bogle, I D L ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Interaction; Modeling; Operations; Optimization; Sequence; Simulation

Indexed keywords

BIOCHEMISTRY; BIOTECHNOLOGY; COMPUTER SIMULATION; ENZYMES; MATHEMATICAL MODELS; OPTIMIZATION; PROCESS ENGINEERING;

ENZYME PRODUCTION;

BIOCHEMICAL ENGINEERING;

ARTICLE; BIOMASS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FERMENTATION; FUNGUS CULTURE; MATHEMATICAL MODEL; NONHUMAN; SACCHAROMYCES CEREVISIAE;

ALCOHOL DEHYDROGENASE; BIOTECHNOLOGY; CENTRIFUGATION; FERMENTATION; FUNGAL PROTEINS; MODELS, BIOLOGICAL; PRECIPITATION; SACCHAROMYCES CEREVISIAE;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0034606980     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(20000205)67:3<300::AID-BIT6>3.0.CO;2-P     Document Type: Article

References (20)

1. Bailey JE, Ollis DF. 1986. Biochemical Engineering Fundamentals. New York: McGraw-Hill.
2. Clarkson AI, Lefevre P, Titchener-Hooker NJ. 1993. A study of process interactions between cell disruption and debris clarification stages in the recovery of yeast intracellular products. Biotechnol Prog 9:462-467.
3. Clarkson AI, Bulmer M, Siddiqi SF, Titchener-Hooker NJ. 1994. Pilot scale verification of bioprocess models. Comput Chem Eng 18(Suppl.):S651-S655.
4. Gregory ME, Bulmer M, Bogle IDL, Tichener-Hooker N. 1996. Optimising enzyme production by bakers yeast continuous culture: Physiological knowledge useful for process design and control. Technical Report A96.6, Centre For Process Systems Engineering, Imperial College of Science, Technology and Medicine, London SW7 2BY, U.K.
5. Groep ME. A Supervisory Control Strategy for Performance Optimisation of Sequences of Interacting Stochastic Biochemical Operations. PhD thesis, University of London, March 1997.
6. Hetherington PJ, Follows M, Dunnill P, Lilly MD. 1971. Release of protein from baker's yeast by disruption in an industrial homogeniser. Trans Inst Chem Eng 49:142-148.
7. Lu Y. 1995. Modelling and simulation of an intracellular enzyme production process. Technical Report C95.22, Centre for Process Systems Engineering, Imperial College of Science, Technology and Medicine, London SW7 2BY, U.K.
8. Lu Y, Clarkson A, Titchener-Hooker N, Pantelides C, Bogle D. 1994. Simulation as a tool in process design and management for production of intracellular enzymes. Trans IChemE 72(Part A):371-375.
9. Mannweiler K, Hoare M. 1992. The scale-down of an industrial disc stack centrifuge. Bioprocess Eng 8:19-25.
10. Middelberg APJ, O'Neill BK, Bogle IDL. 1992. Modelling bioprocess interactions for optimal design and operating strategies. Trans IChemE 70(Part C):8-12.
11. Middelberg APJ. 1995. The importance of accounting for bioprocess interactions. Australasian Biotechnol 5(4):99-103.
12. Morgan SW. 1992. Use process integration to improve process designs and the design process. Chem Eng Prog September: 62-68.
13. Niktari M, Chard S, Richardson P, Hoare M. 1990. The monitoring and control of protein purification and recovery processes. In: Pyle DL, editor. Separations for Biotechnology. London: Elsevier. p 622-634.
14. Perkins JD, Sargent RWH. 1982. Speedup: A computer program for steady-state and dynamic simulation and design of chemical processes. AIChemE Symp Ser 244(78):1-11.
15. Pomerleau Y, Viel G. 1992. Industrial application of adaptive nonlinear control for bakers' yeast production. In: Pyle DL, editor. IFAC Modelling and Control of Biotechnol Processes, London: Elsevier. p 315-317.
16. Richardson JF, Zaki WN. 1954. Sedimentation and fluidisation: Part 1. Trans Inst Chem Eng 32:35-53.
17. Ayazi Shamlou P, Siddiqi SF, Titchener-Hooker NJ. 1995. A physical model of high-pressure disruption of bakers' yeast cells. Chem Eng Sci 50(9):1383-1391.
18. Siddiqi SF, Bulmer M, Ayazi Shamlou P, Tichener-Hooker NJ. 1995. The effects of fermentation conditions on yeast cell debris particle size distributions during high pressure homogenisation. Bioprocess Eng 14:1-8.
19. Simutis R, Havik I, Luebbert A. 1992. Process state estimation and prediction in a production-scale beer fermentation using fuzzy-aided extended kalman filter and neural networks. In: Karim MN, Stephanopoulos G, editors. IFAC Modelling and Control of Biotechnical Processes. Oxford: Pergamon. p 95-100.
20. Yuan JQ, Bellgardt KH. 1992. Structured segregated model for optimal profit control of baker's yeast production. In: IFAC Modeling and Control of Biotechnical Processes. p 53-58.