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Volumn 29, Issue 4, 2000, Pages 215-223

Mode of action of glucocorticoids;Mode d'action des glucocorticoides

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; DNA; IMMUNOSUPPRESSIVE AGENT; STEROID;

EID: 0034606837     PISSN: 07554982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (13)

References (49)
  • 2
    • 0001935854 scopus 로고    scopus 로고
    • Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones
    • Eds Goodman & Gilman
    • Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In The pharmacological basis of therapeutics. Eds Goodman & Gilman 1996 ; 1459-85.
    • (1996) The Pharmacological Basis of Therapeutics , pp. 1459-1485
    • Schimmer, B.P.1    Parker, K.L.2
  • 3
    • 0023769378 scopus 로고
    • The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
    • Freedman LP, Luisi BF, Korszun RZ et al. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature 1988 ; 334:543-6.
    • (1988) Nature , vol.334 , pp. 543-546
    • Freedman, L.P.1    Luisi, B.F.2    Korszun, R.Z.3
  • 5
    • 0024356431 scopus 로고
    • Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor
    • Danielsen M, Hinck L, Ringold GM. Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor. Cell 1989 ; 57:1131-8.
    • (1989) Cell , vol.57 , pp. 1131-1138
    • Danielsen, M.1    Hinck, L.2    Ringold, G.M.3
  • 6
    • 0023441954 scopus 로고
    • Two signals mediate hormone dependent nuclear localization of the glucocorticoid receptor
    • Picard D, Yamamoto KR. Two signals mediate hormone dependent nuclear localization of the glucocorticoid receptor. EMBO J 1987 ; 6:3333-40.
    • (1987) EMBO J , vol.6 , pp. 3333-3340
    • Picard, D.1    Yamamoto, K.R.2
  • 7
    • 0026632462 scopus 로고
    • Hormonal regulation of the nuclear localization signals of the glucocorticosteroid receptor
    • Cadepond F, Gasc JM, Delahaye F et al. Hormonal regulation of the nuclear localization signals of the glucocorticosteroid receptor. Exp Cell Res 1992 ; 201:99-108.
    • (1992) Exp Cell Res , vol.201 , pp. 99-108
    • Cadepond, F.1    Gasc, J.M.2    Delahaye, F.3
  • 8
    • 0343593519 scopus 로고
    • Nuclear receptors
    • Academic Press
    • Bolander FF. Nuclear receptors. In: Molecular endocrinology. Academic Press, 1994 ; 118-48.
    • (1994) Molecular Endocrinology , pp. 118-148
    • Bolander, F.F.1
  • 9
    • 0030024586 scopus 로고    scopus 로고
    • Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination
    • Zhang S, Liang X, Danielsen M. Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination. Mol Endocrinol 1996 ; 10:24-34.
    • (1996) Mol Endocrinol , vol.10 , pp. 24-34
    • Zhang, S.1    Liang, X.2    Danielsen, M.3
  • 10
    • 0023649571 scopus 로고
    • Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor
    • Hollenberg SM, Giguere V, Segui P, Evans RE. Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor Cell 1987 ; 49:39-46.
    • (1987) Cell , vol.49 , pp. 39-46
    • Hollenberg, S.M.1    Giguere, V.2    Segui, P.3    Evans, R.E.4
  • 11
    • 0023235562 scopus 로고
    • Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation
    • Miesfeld R, Godowski PJ, Maler BA, and Yamamoto KR. Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation. Science 1987 ; 236:423-7.
    • (1987) Science , vol.236 , pp. 423-427
    • Miesfeld, R.1    Godowski, P.J.2    Maler, B.A.3    Yamamoto, K.R.4
  • 12
    • 0023789310 scopus 로고
    • A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
    • Picard D, Salser SJ, Yamamoto KR. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 1988 ; 54:1073-80.
    • (1988) Cell , vol.54 , pp. 1073-1080
    • Picard, D.1    Salser, S.J.2    Yamamoto, K.R.3
  • 13
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrine Reviews 1997 ; 18:306-60.
    • (1997) Endocrine Reviews , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 14
    • 0026629289 scopus 로고
    • Monovalentication selectivity for ATP-dependent association of the glucocorticoid receptor with hsp 70 and hsp 90
    • Hutchinson KA, Czar MJ, Scherrer LC, Pratt WB. Monovalentication selectivity for ATP-dependent association of the glucocorticoid receptor with hsp 70 and hsp 90. J Biol Chem 1992 ; 267:14047-53.
    • (1992) J Biol Chem , vol.267 , pp. 14047-14053
    • Hutchinson, K.A.1    Czar, M.J.2    Scherrer, L.C.3    Pratt, W.B.4
  • 15
    • 0029885423 scopus 로고
    • Interaction of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp 70
    • Chen S, Prapapanich V, Rimerman RA, Honoré B, Smith DF. Interaction of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp 70. Mol Endocrinol 1993 ; 10: 682-93.
    • (1993) Mol Endocrinol , vol.10 , pp. 682-693
    • Chen, S.1    Prapapanich, V.2    Rimerman, R.A.3    Honoré, B.4    Smith, D.F.5
  • 16
    • 0029075280 scopus 로고
    • Binding of p23 and hsp 90 during assembly with the progesterone receptor
    • Johnson JL, Toft DO. Binding of p23 and hsp 90 during assembly with the progesterone receptor. Mol Endocrinol 1995 ; 9:670-8.
    • (1995) Mol Endocrinol , vol.9 , pp. 670-678
    • Johnson, J.L.1    Toft, D.O.2
  • 17
    • 0030869037 scopus 로고    scopus 로고
    • Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery
    • Dittmar KD, Demady DR, Stancato LF, Krishna P, Pratt WB. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. J Biol Chem 1997 ; 272:21213-20.
    • (1997) J Biol Chem , vol.272 , pp. 21213-21220
    • Dittmar, K.D.1    Demady, D.R.2    Stancato, L.F.3    Krishna, P.4    Pratt, W.B.5
  • 18
    • 0031757167 scopus 로고    scopus 로고
    • Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton
    • Galigniana MD, Scruggs JL, Herrington J et al. Heat Shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton. Mol Endocrinol 1998 ; 12:1903-13.
    • (1998) Mol Endocrinol , vol.12 , pp. 1903-1913
    • Galigniana, M.D.1    Scruggs, J.L.2    Herrington, J.3
  • 19
    • 0030046766 scopus 로고    scopus 로고
    • Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking
    • Yang J, DeFranco DB. Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking. Mol Endocrinol 1996 ; 10:3-13.
    • (1996) Mol Endocrinol , vol.10 , pp. 3-13
    • Yang, J.1    DeFranco, D.B.2
  • 20
    • 0032929622 scopus 로고    scopus 로고
    • Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor
    • Savory JGA, Hsu B, Laquian IR. Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol 1999 ; 19:1025-37.
    • (1999) Mol Cell Biol , vol.19 , pp. 1025-1037
    • Savory, J.G.A.1    Hsu, B.2    Laquian, I.R.3
  • 22
    • 0029863813 scopus 로고    scopus 로고
    • ATP-dependent release of glucocorticoid receptors from the nuclear matrix
    • Tang Y, DeFranco DB. ATP-dependent release of glucocorticoid receptors from the nuclear matrix. Mol Cell Biol 1996 ; 16:1989-2001.
    • (1996) Mol Cell Biol , vol.16 , pp. 1989-2001
    • Tang, Y.1    DeFranco, D.B.2
  • 23
    • 0027135889 scopus 로고
    • Macromolecular domains within the cell nucleus
    • Spector DL. Macromolecular domains within the cell nucleus. Annu Rev Cell Biol 1993 ; 9:265-315.
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 265-315
    • Spector, D.L.1
  • 24
    • 0012800613 scopus 로고    scopus 로고
    • Subcellular and subnuclear trafficking of steroid receptor
    • Freedman LP ed. Birkhäuser, Boston
    • DeFranco DB. Subcellular and subnuclear trafficking of steroid receptor. In: Molecular Biology of Steroid and Nuclear Hormone Receptors. Freedman LP ed. Birkhäuser, Boston, 1998, 19-34.
    • (1998) Molecular Biology of Steroid and Nuclear Hormone Receptors , pp. 19-34
    • DeFranco, D.B.1
  • 25
    • 0019131149 scopus 로고
    • The specific binding of estrogens and androgens to the nuclear matrix of sex responsive tissues
    • Barrack ER, Coffey DS. The specific binding of estrogens and androgens to the nuclear matrix of sex responsive tissues. J Biol Chem 1980 ; 255:7265-75.
    • (1980) J Biol Chem , vol.255 , pp. 7265-7275
    • Barrack, E.R.1    Coffey, D.S.2
  • 26
    • 0032160629 scopus 로고    scopus 로고
    • The DNA-binding and tau2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal
    • Tang Y, Getzenberg RH, Vietmeier BN et al. The DNA-binding and tau2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal. Mol Endocrinol 1998 ; 12:1420-31.
    • (1998) Mol Endocrinol , vol.12 , pp. 1420-1431
    • Tang, Y.1    Getzenberg, R.H.2    Vietmeier, B.N.3
  • 27
    • 0031056844 scopus 로고    scopus 로고
    • Control by basal phosphorylation of cell cycle-dependent, hormone-induced glucocorticoid receptor hyperphosphorylation
    • Hu J-M, Bodwell JE, Munck A. Control by basal phosphorylation of cell cycle-dependent, hormone-induced glucocorticoid receptor hyperphosphorylation. Mol Endocrinol 1997 ; 11:305-11.
    • (1997) Mol Endocrinol , vol.11 , pp. 305-311
    • Hu, J.-M.1    Bodwell, J.E.2    Munck, A.3
  • 28
    • 0030998260 scopus 로고    scopus 로고
    • Mitogen-activated and cyclin-cependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor
    • Krstic M, Rogatsky I, Yamamoto KR, Garabedian MJ. Mitogen-activated and cyclin-cependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol 1997 ; 17:3947-54.
    • (1997) Mol Cell Biol , vol.17 , pp. 3947-3954
    • Krstic, M.1    Rogatsky, I.2    Yamamoto, K.R.3    Garabedian, M.J.4
  • 29
    • 0027402820 scopus 로고
    • Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene
    • Drouin J, Lin Sun Y, Chamberland M et al. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 1993 ; 12:14556.
    • (1993) EMBO J , vol.12 , pp. 14556
    • Drouin, J.1    Lin Sun, Y.2    Chamberland, M.3
  • 31
    • 0025188132 scopus 로고
    • Transcriptional interference between c-Jun and the glucocorticoid receptor : Mutual inhibition of DNA binding due to direct protein-protein interaction
    • Yang-Yen H-F, Chambard J-C, Sun Y-L et al. Transcriptional interference between c-Jun and the glucocorticoid receptor : mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 1990 ; 62:1205-15.
    • (1990) Cell , vol.62 , pp. 1205-1215
    • Yang-Yen, H.-F.1    Chambard, J.-C.2    Sun, Y.-L.3
  • 32
    • 0025130179 scopus 로고
    • Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
    • Schule R, Rangarajan P, Kliewer S et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990 ; 62:1217-25.
    • (1990) Cell , vol.62 , pp. 1217-1225
    • Schule, R.1    Rangarajan, P.2    Kliewer, S.3
  • 33
    • 0025015647 scopus 로고
    • Antitumor promotion and antiinflammation : Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
    • Jonat C, Rahmsdorf HJ, Park K-K et al. Antitumor promotion and antiinflammation : down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 1990 ; 62:1189-1204.
    • (1990) Cell , vol.62 , pp. 1189-1204
    • Jonat, C.1    Rahmsdorf, H.J.2    Park, K.-K.3
  • 34
    • 0028909667 scopus 로고
    • Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids
    • Caldenhoven E, Liden J, Wissink S et al. Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol Endocrinol 1995 ; 9:401-12.
    • (1995) Mol Endocrinol , vol.9 , pp. 401-412
    • Caldenhoven, E.1    Liden, J.2    Wissink, S.3
  • 35
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NFkB activity through induction of IkB synthesis
    • Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NFkB activity through induction of IkB synthesis. Science 1995 ; 270:286-90.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    DiDonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 36
    • 0030846576 scopus 로고    scopus 로고
    • Promoter dependent synergy between glucocorticoid receptor and STAT5 in the activation of b-casein gene transcription
    • Lechner J, Welte T, Tomasi JK et al. Promoter dependent synergy between glucocorticoid receptor and STAT5 in the activation of b-casein gene transcription. J Biol Chem 1997 ; 272:20954-60.
    • (1997) J Biol Chem , vol.272 , pp. 20954-20960
    • Lechner, J.1    Welte, T.2    Tomasi, J.K.3
  • 37
    • 0030868701 scopus 로고    scopus 로고
    • Specific DNA binding of STAT 5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription
    • Stoecklin E, Wissler M, Moriggl R, Groner B. Specific DNA binding of STAT 5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription. Mol Cell Biol 1997 ; 17:6708-16
    • (1997) Mol Cell Biol , vol.17 , pp. 6708-6716
    • Stoecklin, E.1    Wissler, M.2    Moriggl, R.3    Groner, B.4
  • 38
    • 0030774374 scopus 로고    scopus 로고
    • Rôle des co-facteurs transcriptionnels dans le transduction des signaux hormonaux par les récepteurs nucléaires
    • Gelman G, Staels B, Auverx J. Rôle des co-facteurs transcriptionnels dans le transduction des signaux hormonaux par les récepteurs nucléaires. Med/Sci 1997; 13:961-70.
    • (1997) Med/Sci , vol.13 , pp. 961-970
    • Gelman, G.1    Staels, B.2    Auverx, J.3
  • 39
    • 0027494730 scopus 로고
    • Anti-inflammatory actions of steroids: Molecular mechanisms
    • Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 1993 ; 14:436-41.
    • (1993) Trends Pharmacol Sci , vol.14 , pp. 436-441
    • Barnes, P.J.1    Adcock, I.2
  • 40
    • 0027409741 scopus 로고
    • Glucocorticoids, lipocortins and the immune response
    • Goulding NJ, Guyre PM. Glucocorticoids, lipocortins and the immune response. Curr Op Immunol 1993 ; 5:108-13.
    • (1993) Curr Op Immunol , vol.5 , pp. 108-113
    • Goulding, N.J.1    Guyre, P.M.2
  • 41
    • 0029870836 scopus 로고    scopus 로고
    • Protein degradation or regulation: Ub the judge
    • Hochstrasser M. Protein degradation or regulation: ub the judge. Cell 1996 ; 84:813-5.
    • (1996) Cell , vol.84 , pp. 813-815
    • Hochstrasser, M.1
  • 42
    • 0028879819 scopus 로고
    • Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids
    • Scheinman RI, Cogswell PC, Lofquist AK, Baldwin Jr AS. Role of transcriptional activation of IkBa in mediation of immunosuppression by glucocorticoids. Science 1995 ; 270:283-6.
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin A.S., Jr.4
  • 43
    • 0030789420 scopus 로고    scopus 로고
    • IkBα-independent downregulation of NFκB activity by glucocorticoid receptor
    • Heck S, Bender K, Kullmann M, Göttlicher M et al. IkBα-independent downregulation of NFκB activity by glucocorticoid receptor. EMBO J 1997 ; 16:4698-707.
    • (1997) EMBO J , vol.16 , pp. 4698-4707
    • Heck, S.1    Bender, K.2    Kullmann, M.3    Göttlicher, M.4
  • 44
    • 0027172987 scopus 로고
    • Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NFAT
    • Paliogianni F, Raptis A, Ahuja SS, Najjar SM, Boumpas DT. Negative transcriptional regulation of human interleukin 2 (IL-2) gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NFAT. J Clin Invest 1993 ; 91:1481-9.
    • (1993) J Clin Invest , vol.91 , pp. 1481-1489
    • Paliogianni, F.1    Raptis, A.2    Ahuja, S.S.3    Najjar, S.M.4    Boumpas, D.T.5
  • 45
    • 0025832496 scopus 로고
    • Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
    • Boumpas DT, Anastassiou ED, Older SA et al. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest 1991 ; 87:1739-47.
    • (1991) J Clin Invest , vol.87 , pp. 1739-1747
    • Boumpas, D.T.1    Anastassiou, E.D.2    Older, S.A.3
  • 46
    • 0029052324 scopus 로고
    • Negative transcriptional regulation of the interferon-g promoter by glucocorticoids and dominant negative mutants of c-Jun
    • Cippitelli M, Sica A, Viggiano V et al. Negative transcriptional regulation of the interferon-g promoter by glucocorticoids and dominant negative mutants of c-Jun. J Biol Chem 1995 ; 270:12548-56.
    • (1995) J Biol Chem , vol.270 , pp. 12548-12556
    • Cippitelli, M.1    Sica, A.2    Viggiano, V.3
  • 47
    • 0032567347 scopus 로고    scopus 로고
    • Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter
    • Wargnier A, Lafaurie C, Legros-Maida S et al. Down-regulation of human granzyme B expression by glucocorticoids. Dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the granzyme B promoter. J Biol Chem 1998 ; 273:35226-31.
    • (1998) J Biol Chem , vol.273 , pp. 35226-35231
    • Wargnier, A.1    Lafaurie, C.2    Legros-Maida, S.3
  • 48
    • 0029774085 scopus 로고    scopus 로고
    • Transcriptional control of steroid-regulated apoptosis in murine thymoma cells
    • Chapman MS, Askew DJ, Kuscuoglu U, Miesfeld RL. Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Mol Endocrinol 1996 ; 10:967-78.
    • (1996) Mol Endocrinol , vol.10 , pp. 967-978
    • Chapman, M.S.1    Askew, D.J.2    Kuscuoglu, U.3    Miesfeld, R.L.4
  • 49
    • 0031474156 scopus 로고    scopus 로고
    • Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo
    • Vayssière BM, Dupont S, Choquart A et al. Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo. Mol Endocrinol 1997 ; 11:1245-55.
    • (1997) Mol Endocrinol , vol.11 , pp. 1245-1255
    • Vayssière, B.M.1    Dupont, S.2    Choquart, A.3


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