Endogenous tissue factor pathway inhibitor modulates thrombus formation in an in vivo model of rabbit carotid artery stenosis and endothelial injury

Circulation

Volumn 102, Issue 1, 2000, Pages 113-117

  Ragni, Massimo ^a   Golino, Paolo ^a   Cirillo, Plinio ^a   Scognamiglio, Annalisa ^a   Piro, Orlando ^a   Esposito, Nicolino ^a   Battaglia, Carmine ^a   Botticella, Filomena ^a   Ponticelli, Paola ^a   Ramunno, Luigi ^a   Chiariello, Massimo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Blood flow; Coagulation; Inhibitors; Thromboplastin

Indexed keywords

BLOOD CLOTTING INHIBITOR; PROTEINASE INHIBITOR; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY FLOW; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; HEMOSTASIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; THROMBOGENESIS;

EID: 0034604267     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.1.113     Document Type: Article

References (23)

1. Davies MJ, Woolf N. Atherosclerosis: what is it and why does it occur? Br Heart J. 1993;69(suppl):S3-S11.
2. Wilcox JN, Smith KN, Schwartz SM, et al. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci U S A. 1989;86:2839-2843.
3. Annex BH, Denning SM, Channon KM, et al. Differential expression of tissue factor protein in directional atherectomy specimens from patients with stable and unstable coronary syndromes. Circulation. 1995;91: 619-622.
4. Toschi V, Gallo R, Lettino M, et al. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation. 1997;95: 594-599.
5. Badimon JJ, Lettino M, Toschi V, et al. Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions. Circulation. 1999;99:1780-1787.
6. Jang IK, Gold HK, Leinbach RC, et al. Antithrombotic effect of a monoclonal antibody against tissue factor in a rabbit model of platelet-mediated arterial thrombosis. Arterioscler Thromb. 1992;12:948-954.
7. Pawashe AB, Golino P, Ambrosio G, et al. A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries. Circ Res. 1994;74:56-63.
8. Ragni M, Cirillo P, Pascucci I, et al. A monoclonal antibody against tissue factor shortens tissue-plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. Circulation. 1996; 93:1913-1918.
9. Golino P, Ragni M, Cirillo P, et al. Antithrombotic effects of recombinant human, active site-blocked factor VIIa in a rabbit model of recurrent arterial thrombosis. Circ Res. 1998;82:39-46.
10. Broze GJ Jr. The role of tissue factor pathway inhibitor in a revised coagulation cascade. Semin Hematol. 1992;29:159-169.
11. Broze GJ Jr, Warren LA, Novotny WF, et al. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. Blood. 1988;71:335-343.
12. Haskel EJ, Torr SR, Day KC, et al. Prevention of arterial reocclusion after thrombolysis with recombinant lipoprotein-associated coagulation inhibitor. Circulation. 1991;84:821-827.
13. Golino P, Ambrosio G, Pascucci I, et al. Experimental carotid stenosis and endothelial injury in the rabbit: an in vivo model to study intravascular platelet aggregation. Thromb Haemost. 1992;67:302-305.
14. Folts JD, Crowell EB Jr, Rowe CG. Platelet aggregation in partially obstructed vessels and its elimination by aspirin. Circulation 1976;54: 365-370.
15. Golino P, Cappelli-Bigazzi M, Ambrosio G, et al. Endothelium-derived relaxing factor modulates platelet aggregation in an in vivo model of recurrent platelet activation. Circ Res. 1992;71:1447-1456.
16. Golino P, Ragni M, Cirillo P, et al. Aurintricarboxylic acid reduces platelet deposition in stenosed and endothelially injured rabbit carotid arteries more effectively than other antiplatelet interventions. Thromb Haemost. 1995;74:974-980.
17. Belaaouaj A, Kuppuswamy MN, Birktoft JJ, et al. Revised cDNA sequence of rabbit tissue factor pathway inhibitor. Thromb Res. 1993;69: 547-553.
18. Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1988.
19. Sanset PM, Warn-Cramer BJ, Rao LVM, et al. Depletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation induced with tissue factor: evidence supporting a physiological role for EPI as a natural anticoagulant. Proc Natl Acad Sci U S A. 1991;88:708-712.
20. Girard TJ, Warren LA, Novotny KM, et al. Functional significance of the Kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. Nature. 1989;338:515-520.
21. Sandset PM, Abildgaard U. Extrinsic pathway inhibitor - the key to feedback control of blood coagulation initiated by tissue thromboplastin. Haemostasis. 1991;21:219-239.
22. Sevinsky JR, Rao LVM, Rul W. Ligand-induced protease receptor translocation into caveolae mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway. J Cell Biol. 1996; 133:293-304.
23. Verstraete M. Biology and chemistry of thrombosis. In: Haber E, Braunwald E, eds. Thrombolysis: Basic Contributions and Clinical Progress. St Louis, Mo: Mosby-Year Book Inc; 1991:3-16.