Encoding of movement time by populations of cerebellar Purkinje cells

Nature

Volumn 405, Issue 6782, 2000, Pages 72-76

  Thier, Peter ^a   Dicke, Peter W ^a   Haas, Roman ^a   Barash, Shabtai ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CALCULATION; CELL POPULATION; LEARNING; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RHESUS MONKEY; SACCADIC EYE MOVEMENT; TIME;

ANIMALS; FEMALE; MACACA MULATTA; MALE; PURKINJE CELLS; REACTION TIME; SACCADES;

EID: 0034604158     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35011062     Document Type: Article

References (29)

1. Braitenberg, V. Functional interpretation of cerebellar histology. Nature 190, 539-640 (1961).
2. Ivry, R. B. & Diener, H. C. Impaired velocity perception in patients with lesions of the cerebellum. J. Cogn. Neurosci. 3, 355-366 (1991).
3. Ivry, R. B. & Keele, S. W. Timing functions of the cerebellum. J. Cogn. Neurosci. 1, 136-152 (1993).
4. Marr, D. A theory of cerebellar cortex. J. Physiol. 202, 437-470 (1969).
5. Ito, M. Cerebellar control of the vestibulo-ocular reflex- around the flocculus hypothesis. Annu. Rev. Neurosci. 5, 275-296 (1932).
6. Kawato, M. & Giomi, H. The cerebellum and VOR/OKR learning models. Trends Neurosci. 15, 445-453 (1992).
7. Raymond, J. L., Lisberger, S. G. & Mauk, M. D. The cerebellum: A neuronal learning machine? Science 272, 1126-1131 (1996).
8. Optican, L. M. & Robinson, D. A. Cerebellar-dependent adaptive control of primate saccadic system. J. Neurophysiol. 44, 1058-1076 (1980).
9. Takagi, M., Zee, D. S. & Tamargo, R. J. Effects of lesions of the oculomotor vermis on eye movement in primate: saccades. J. Neurophysiol. 80, 1911-1931 (1998).
10. Barash, S. et al. Saccadic dysmetria and adaptation after lesions of the cerebellar cortex. J. Neurosci. 19, 10931-10939 (1999).
11. Fitzgibbon, E. J. & Goldberg, R. A. in Adaptive Processes in Visual and Oculomotor Systems (eds Keller, B. L. & Zee, D. S.) 329-333 (Pergamon, Oxford, 1986).
12. Llinás, R. & Wolfe, J. W. Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements. Exp. Brain Res. 29, 1-14 (1977).
13. Kase, M., Miller, D. C. & Noda, H. Discharges of Purkinje cells and mossy fibers in the cerebellar vermis of the monkey during saccadic eye movements and fixation. J. Physiol. (Lond.) 300, 539-555 (1980).
14. Sato, H. & Noda, H. Posterior vermal Purkinje cells in macaques responding during saccades, smooth pursuit, chair rotation and/or optokinetic stimulation. Neurosci. Res. 12, 583-595 (1992).
15. Helmchen, C. & Büttner, U. Saccade-related Purkinje cell activity in the oculomotor vermis during spontaneous eye movements in light and darkness. Exp. Brain Res. 103, 198-208 (1995).
16. Bahill, A. T., Clark, S.A. & Stark, R. J. The main sequence, a tool for studying human eye movements. Math. Biosci. 24, 287-298 (1975).
17. Desmurget, M. et al. Functional anatomy of saccadic adaptation in humans. Nature Neurosci. 1, 524-528 (1998).
18. Ohtsuka, K. & Noda, H. Saccadic burst neurons in the oculomotor region of the fastigial nucleus of macaque monkey. J. Neurophysiol. 65, 1422-1434 (1991).
19. Fuchs, A. F., Robinson, F. R. & Straube, A. Role of caudal fastigial nucleus in saccade generation. I. Neuronal discharge patterns. J. Neurophysiol. 70, 1723-1740 (1993).
20. Noda, H., Sugita, S. & Ikeda, Y. Afferent and efferent connections of the oculomotor region of the fastigial nucleus in the macaque monkey. J. Comp. Neurol. 302, 330-348 (1990).
21. Scudder, C. A. Discharge of fastigial nucleus neurons is altered during adaptive modification of saccade size. Soc. Neurosci. Abstr. 24, 147 (1998).
22. Llinás, R. & Mühlethaler, M. Electrophysiology of guinea-pig cerebellar nuclear cells in the in vitro brain stem-cerebellar preparation. J. Physiol. (Lond.) 404, 241-258 (1988).
23. Aizenmann, C. D. & Linden, D. J. Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. J. Neurophysiol. 82, 1697-1709 (1999).
24. Judge, S. J., Richmond, B. J. & Chu, F. C. Implantation of magnetic search coils for measurement of eye position: an improved method. Vision Res. 20, 535-538 (1980).
25. Thier, P. & Erickson, R. G. Responses of visual-tracking neurons from cortical area MSTI to visual, eye and head motion. Eur. J. Neurosci. 4, 339-553 (1992).
26. Thielert, C.-D. Elektrophysiologische und Anatomische Untersuchungen zum Okulomotorischen Beitrag des Posterioren Vermis des Rhesusaffen. Thesis, Eberhard-Karls-Universität Tübingen (1996).
27. Haas, R., Dicke, P. W. & Thier, P. Saccade-related responses of most posterior vermal Purkinje cells do not depend on the starting position of the eyes. Soc. Neurosci. Abstr. 25, 1652 (1999).
28. Hanes, D. P., Thompson, K. G. & Schall, J. D. Relationship of presaccadic activity in frontal eye field and supplementary eye field to saccade initiation in macaque: Poisson spike train analysis. Exp. Brain Res. 103, 85-96 (1995).
29. Press, H. W., Teukolsky, S. A., Vetterling, W. T. & Flannery, B. P.(eds) Numerical Recipes in C, 650-655 (Cambridge Univ. Press, Cambridge, 1992).