Transposing sequences between fetal and adult hemoglobins indicates which subunits and regulatory molecule interfaces are functionally related

Biochemistry

Volumn 39, Issue 13, 2000, Pages 3774-3781

  Chen, Weihua ^a   Dumoulin, Antoine ^a,b   Li, Xianfeng ^a,c   Padovan, Julio Cesar ^d   Chait, Brian T ^d   Buonopane, Ralph ^e   Platt, Orah S ^f   Manning, Lois R ^a   Manning, James M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b ValiGene   (France)

^c ELI LILLY AND COMPANY   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e Northeastern University   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; HEMOGLOBIN CHAIN; HEMOGLOBIN F; TETRAMER;

ALLOSTERISM; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; DISSOCIATION CONSTANT; HEMOGLOBIN DETERMINATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

2,3-DIPHOSPHOGLYCERATE; ADULT; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BINDING SITES; DIMERIZATION; FETAL HEMOGLOBIN; GLYCINE; HEMOGLOBIN A; HEMOGLOBINS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; VALINE;

EID: 0034603802     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992691l     Document Type: Article

References (25)

1. Perutz, M. (1989) Annu. Rev. Biophys. 22, 139-237.
2. Arnone, A. (1972) Nature 237, 146-149.
3. Benesch, R., Benesch, R. E., and Yu, C. I. (1968) Proc. Natl. Acad. Sci. U.S.A. 59, 526-532.
4. Bunn, H. F., and Briehl, R. W. (1970) J. Clin. Invest. 49, 1088-1095.
5. Dumoulin, A., Manning, L. R., Jenkins, W. T., Winslow, R. M., and Manning, J. M. (1997) J. Biol. Chem. 272, 31 326-31 332.
6. Turner, G. J., Galacteros, F., Doyle, M. L., Hedlund, B., Pettigrew, D. W., Turner, B. W., Smith, F. R., Moo-Penn, W., Rucknagel, D. L., and Ackers, G. K. (1992) Proteins: Struct., Funct., Genet. 14, 333-350.
7. Dumoulin, A., Padovan, J. C., Manning, L. R., Popowicz, A., Winslow, R. M., Chait, B. T., and Manning, J. M. (1998) J. Biol. Chem. 27, 35032-35038.
8. Manning, J. M., Dumoulin, A., Manning, L. R., Chen, W., Padovan, J. C., and Chait, B. T. (1999) Trends Biochem. Sci. 24, 211-212.
9. Gros, G., and Bauer, C. (1978) Biochem. Biophys. Res. Commun. 80, 56-62.
10. Platt, O., Orkin, S. H., Dover, G., Beardsley, G. P., Miller, B., and Nathan, D. G. (1984) J. Clin. Invest. 24, 652-656.
11. Manning, L. R., Jenkins, W. T., Hess, J. R., Vandegriff, K., Winslow, R. M., and Manning, J. M. (1996) Protein Sci. 5, 775-781.
12. Wagenbach, M., O'Rourke, K., Vitez, L., Wieczorek, A., Hoffman, S., Durfee, S., Tedesco, J., and Stetler, G. (1991) Biotechnology 9, 57-61.
13. Martin de Llano, J. J., and Manning, J. M. (1994) Protein Sci. 3, 1206-1212.
14. Li, X., Himanen, J.-P., Martin de Llano, J. J., Padovan, J. C., Chait, B. T., and Manning, J. M. (1999) Biotechnol. Appl. Biochem. 29, 165-184.
15. Biemann, K. (1990) Methods Enzymol. 193, 886-887.
16. Manning, L. R., Dumoulin, A., Jenkins, W. T., Winslow, R. M., and Manning, J. M. ( 1999) Methods Enzymol. 306, 113-129.
17. Martin de Llano, J. J., Schneewind, O., Stetler, G., and Manning, J. M. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 918-922.
18. Martin de Llano, J. J., Jones, W., Schneider, K., Chait, B. T., Manning, J. M., Rodgers, G., Benjamin, L. J., and Weksler, B. (1993) J. Biol. Chem. 268, 27 004-27 011.
19. Yanase, H., Cahill, S., Martin de Llano, J. J. Manning, L. R. Schneider, K., Chait, B. T., Vandegriff, K. D., Winslow, R. M., and Manning, J. M. (1994) Protein. Sci. 3, 1213-1223.
20. Fronticelli, C., Gattoni, M., Lu, A. L., Brinigar, W. S., Bucci, J. L., and Chiancone, E. (1994) Biophys. Chem. 51, 53-57.
21. Perutz, M. F., Shih, D. T., and Williamson, D. (1994) J. Mol. Biol. 239, 555-560.
22. Fang, T.-Y., Zow, M., Simplacenu, V., Ho, N. T., and Ho, C. (1999) Biochemistry 38, 13 423-13 432.
23. Frier, J. A., and Perutz, M. F. (1997) J. Mol. Biol. 112, 97-112.
24. Bonaventura, C., Arumugam, M., Cashon, R., Bonaventura, J., and Moo-Penn, W. F. (1994) J. Mol. Biol. 239, 561-568.
25. Ueno, H., Popowicz, A. M., and Manning, J. M. (1993) J. Protein. Chem. 12, 561-570.