Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions: Relationship to GABA(A) receptor subunit expression

Brain Research

Volumn 882, Issue 1-2, 2000, Pages 139-148

  Lilly, Scott M ^a   Tietz, Elizabeth I ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Anticonvulsant; Anxiety; Benzodiazepine; Cocaine; Elevated plus maze; Pentylenetetrazol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; COCAINE; DIAZEPAM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANXIETY NEUROSIS; ARTICLE; BRAIN REGION; COCAINE DEPENDENCE; DENTATE GYRUS; DRUG EFFECT; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; ANXIETY; COCAINE; CONVULSANTS; DIAZEPAM; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; HIPPOCAMPUS; MALE; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES;

EID: 0034602246     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02858-4     Document Type: Article

References (50)

1. Guidelines for the rational use of benzodiazepines
2. Corticotropin-releasing factor antagonist attenuates the 'anxiogenic-like' effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats
3. Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats
4. Cocaine augments peripheral benzodiazepine binding in humans
5. Benzodiazepine-mediated regulation of α1-2, β1-3 and γ2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex
6. Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze
7. The actions of nicotine and cocaine in a mouse model of anxiety
8. Reinforcing properties of lorazepam in normal volunteers
9. Inhibition of the Na+, K+ pump by the epileptogenic pentylenetetrazole
10. Dizocilpine does not prevent the development of tolerance to the anxiolytic effects of diazepam in rats
11. The validation of animal tests of anxiety - Phamacological implications
12. GABA(A) receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
13. Cocaine differentially affects benzodiazepine receptors in discrete regions of the rat brain: Persistence and potential mechanisms mediating these effects
14. Tolerance and sensitization to the behavioral effects of cocaine in rats: Relationship to benzodiazepine receptors
15. Benzodiazepine self-administration in humans and laboratory animals - Implications for problems of long-term use and abuse
16. Benzodiazepines in the treatment of epilepsy
17. Immunocytochemical detection of regional protein changes in rat brain sections using computer-assisted image analysis
18. Rapid tolerance and cross-tolerance to motor impairment effects of benzodiazepines, barbiturates and ethanol
19. Continuous cocaine induces persisting changes in behavioral responsivity to both scopolamine and diazepam
20. Length of continuous cocaine exposure determines the persistence of muscarinic and benzodiazepine receptor alterations
21. The use of a plus-maze to measure anxiety in the mouse
22. GABA(A) receptor channels
23. Identification and preclinical testing of novel antiepileptic compounds
24. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
25. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat
26. Repeated cocaine injections decrease the function of striatal γ-aminobutyric acid(A) receptors
27. Antisense inhibition of striatal GABA(A) receptor proteins decreases GABA-stimulated chloride uptake and increases cocaine sensitivity in rats
28. Sensitization and kindling effects of chronic cocaine administration
29. Psychotropic drug tolerance and dependence: Common underlying mechanisms?
30. Chemical restraint for the agitated patient in the emergency department: Lorazepam versus droperidol
31. Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats
32. Current concepts in psychiatry: The drug treatment of anxiety
33. Differential expression of benzodiazepine anticonvulsant cross-tolerance according to time following flurazepam or diazepam treatment
34. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
35. One-way cross-sensitization and cross-tolerance to seizure activity from cocaine to lidocaine
36. Pharmacokinetics, metabolism, and disposition of cocaine
37. Structure and pharmacology of γ-aminobutyric acid(A) receptor subunits
38. Genetic inactivation of the serotonin(A) receptor in mice results in downregulation of major GABA(A) receptor α subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety
39. Prenatal cocaine exposure increases susceptibility to drug-induced seizures
40. Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain
41. Cocaine
42. Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance
43. Cocaine: Evidence for NMDA-, β-carboline- and dopaminergic-mediated seizures in mice
44. Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: A PET study
45. Acute pentylenetetrazol injection reduces rat GABA(A) receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density
46. Psychomotor Stimulants
47. Anticonvulsant efficacy of N-Methyl-D-Aspartate antagonists against convulsions induced by cocaine
48. Reduction in potency of selective γ-aminobutyric acid(A) agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats
49. 2 subunit increases convulsive threshold for β-CCM, a benzodiazepine 'inverse agonist', in rats
50. Brain corticotropin-releasing factor mediates 'anxiety-like' behavior induced by cocaine withdrawal in rats