Pigment-epithelium-derived factor - A key coordinator of retinal neuronal and vascular functions

New England Journal of Medicine

Volumn 342, Issue 5, 2000, Pages 349-351

  King, George L ^a   Suzuma, Kiyoshi ^a  

^a JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; TRANSFORMING GROWTH FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BLOOD FLOW; CHOROID CAPILLARY LAYER; HUMAN; NERVE CELL DIFFERENTIATION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA LUTEA;

EYE PROTEINS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTORS; PROTEINS; RETINAL DISEASES; RETINAL VESSELS; SERPINS;

EID: 0034598756     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200002033420511     Document Type: Article

References (5)

1. Casey R, Li WW. Factors controlling ocular angiogenesis. Am J Ophthalmol 1997;124:521-9.
2. Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331:1480-7.
3. Dawson DW, Volpert OV, Gillis P, et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285:245-8.
4. Steele FR, Chader GJ, Johnson LV, Tombran-Tink J. Pigment epithelium-derived factor: neutrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci U S A 1993; 90:1526-30.
5. Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton DR. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1996;37:855-68.