The effect of a single gavage dose of fumonisin B1 on the sphinganine and sphingosine levels in vervet monkeys

Toxicon

Volumn 39, Issue 2-3, 2001, Pages 273-281

  Van Der Westhuizen, L ^a   Shephard, G S ^a   Van Schalkwyk, D J ^b  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b CAPE PENINSULA UNIVERSITY OF TECHNOLOGY   (South Africa)

Author keywords

Fumonisin; Sphinganine; Sphingosine; Vervet monkeys

Indexed keywords

CHOLESTEROL; FUMONISIN B1; LIVER ENZYME; SPHINGANINE; SPHINGOSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; FEEDING; FEMALE; KIDNEY; LIVER FUNCTION; LIVER LEVEL; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; SAMPLE; SERUM; TISSUE LEVEL; URINE LEVEL;

CERCOCEBUS; CERCOPITHECUS; CERCOPITHECUS AETHIOPS;

EID: 0034598647     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(00)00125-2     Document Type: Conference Paper

References (40)

1. Aranda-Michel J., Sherman K.E. Tests of the liver: Use and misuse. Gastroenterologist. 6:1998;34-43.
2. Castegnaro M., Garren L., Gaucher I., Wild C.P. Development of a new method for the analysis of sphinganine and sphingosine in urine and tissues. Nat. Toxins. 4:1996;284-290.
3. Cawood M.E., Gelderblom W.C.A., Vleggaar R., Behrend Y., Thiel P.G., Marasas W.F.O. Isolation of the fumonisin mycotoxins: a quantitative approach. J. Agric. Food Chem. 39:1991;1958-1962.
4. 1 and other mycotoxins in moldy corn collected from the Republic of China in regions with high incidences of Esophageal cancer. Appl. Environ. Microbiol. 60:1994;847-852.
5. Fincham J.E., Marasas W.F.O., Taljaard J.J.F., Kriek N.P.J., Badenhorst C.J., Gelderblom W.C.A., Seier J.V., Smuts C.M., Weight M.J., Slazus W., Woodroof C.W., Van Wyk M.J., Kruger M., Thiel P.G. Atherogenic effects in a non-human primate of Fusarium moniliforme cultures added to a carbohydrate diet. Atherosclerosis. 94:1992;13-25.
6. 1, in rats. Carcinogenesis. 12:1991;1247-1251.
7. Gelderblom W.C.A., Snyman S.D., Abel S., Lebepe-Mazur S., Smuts C.M., Van der Westhuizen L., Marasas W.F.O., Victor T.C., Knasmuller S., Huber W. Hepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humans. Adv. Exp. Med. Biol. 392:1996;279-296.
8. Goel S., Schumacher J., Lenz S.D., Kemppainen B.W. Effects of Fusarium moniliforme isolates on tissue and serum sphingolipid concentrations in horses. Vet. Hum. Toxicol. 38:1996;265-270.
9. 1 in rabbits: Nephrotoxicity and sphingolipid alterations. Nat. Toxins. 3:1995;395-403.
10. Gumprecht L.A., Beasley V.R., Weigel R.M., Parker H.M., Tumbleson M.E., Bacon C.W., Meredith F.I., Haschek W.M. Development of fumonisin-induced hepatotoxicity and pulmonary edema in orally dosed swine: morphological and biochemical alterations. Toxicol. Pathol. 26:1998;777-788.
11. 1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 2:1990;217-221.
12. Johnston D.E. Special considerations in interpreting liver function tests. Am. Fam. Physician. 15:1999;2223-2230.
13. 1. Onderstepoort J. Vet. Res. 57:1990;269-275.
14. Loeb W.F. The measurement of renal injury. Toxicol. Pathol. 26:1998;26-28.
15. 1 induces cell proliferation and apoptosis in the rat. Nat. Toxins. 4:1996;34-41.
16. 1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55:1988;197-203.
17. Marasas W.F.O. Risk assessment of fumonisins produced by Fusarium moniliforme in corn. Cereal Res. Comm. 25:1997;399-406.
18. Merrill A.H. Jr., Wang E., Gilchrist D.G., Riley R.T. Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Adv. Lipid Res. 26:1993;215-234.
19. Merrill A.H. Jr., Schmelz E.-M., Dillehay D.L., Spiegel S., Shayman J.A., Schroeder J.J., Riley R.T., Voss K.A., Wang E. Sphingolipids - the enigmatic lipid class: biochemistry, physiology and pathophysiology. Toxicol. Appl. Pharmacol. 142:1997;208-225.
20. Norred W.P., Plattner R.D., Dombrink-Kurtzman M.A., Meredith F.I., Riley R.T. Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships. Toxicol. Appl. Pharmacol. 147:1997;63-70.
21. Rheeder J.P., Marasas W.F.O., Thiel P.G., Sydenham E.W., Shephard G.S., Van Schalkwyk D.J. Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology. 82:1992;353-357.
22. Riley R.T., An N.-H., Showker J.L., Yoo H.-S., Norred W.P., Chamberlain W.J., Wang E., Merrill A.H. Jr., Motelin G., Beasley V.R., Haschek W.M. Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker for exposure to fumonisin-containing feeds in pigs. Toxicol Appl. Pharmacol. 118:1993;105-112.
23. Riley R.T., Wang E., Merrill A.H. Jr. Liquid chromatographic determination of sphinganine and sphingosine: use of the free sphinganine-to-sphingosine ratio as a biomarker for consumption of fumonisins. J. AOAC Int. 77:1994;533-540.
24. 1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. J. Nutr. 124:1994;594-603.
25. Ross P.F., Ledet A.E., Owens D.L., Rice L.G., Nelson H.A., Osweiler G.D., Wilson T.M. Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins. J. Vet. Diagn. Invest. 5:1993;69-74.
26. Rother J., Van Echten G., Schwarzmann G., Sandhoff K. Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189:1992;14-20.
27. 1 in a non-human primate. Toxicon. 32:1994;735-741.
28. 1 in vervet monkeys. Nat. Toxins. 3:1995;145-150.
29. Shephard G.S., Thiel P.G., Stockenström S., Sydenham E.W. Worldwide survey of fumonisin contamination of corn and corn-based products. J. AOAC Int. 79:1996;671-687.
30. Shephard G.S., Van der Westhuizen L., Thiel P.G., Gelderblom W.C.A., Marasas W.F.O., Van Schalkwyk D.J. Disruption of sphingolipid metabolism in non-human primates consuming diets of fumonisin-containing Fusarium moniliforme culture material. Toxicon. 34:1996;527-534.
31. 2: comparative studies in rats and non-human primates. Miragalia M., Van Egmond H., Brera C., Gilbert J. Mycotoxins and Phycotoxins - Developments in Chemistry, Toxicology and Food Safety. 1998;517-522 Alaken Inc, Fort Collins, CO, USA.
32. Theal R.M., Scott K. Evaluating asymptomatic patients with abnormal liver function test results. Am. Fam. Physician. 53:1996;2111-2119.
33. Thiel P.G., Marasas W.F.O., Sydenham E.W., Shephard G.S., Gelderblom W.C.A. The implications of naturally occurring levels of fumonisins in corn for human and animal health. Mycopathologia. 117:1992;3-9.
34. 1 and other structurally related compounds. Food Chem. Toxicol. 36:1998;497-503.
35. 1. Nat. Toxins. 1:1993;222-228.
36. 1 to male and female rats. Food. Addit. Contam. 12:1995;473-478.
37. Wang E., Ross P.F., Wilson T.M., Riley R.T., Merrill A.H. Jr. Inhibition of sphingolipid biosynthesis by fumonisins - implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266:1991;14486-14490.
38. Wang E., Ross P.F., Wilson T.M., Riley R.T., Merrill A.H. Jr. Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. J. Nutr. 122:1992;1706-1716.
39. 1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. J. Nutr. 129:1999;214-220.
40. 1 cells. Toxicol Appl. Pharmacol. 114:1992;9-15.