6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism- based inhibitors of human leukocyte elastase

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 27-30

  Kerrigan, John E ^a,b   Walters, Matthew C ^a   Forrester, Kerri J ^a   Crowder, Jason B ^a   Christopher, Lisa J ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; ISOINDOLE DERIVATIVE; LEUKOCYTE ELASTASE INHIBITOR;

ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; REACTION ANALYSIS;

CHYMOTRYPSIN; HUMANS; INDOLES; KINETICS; LEUKOCYTE ELASTASE; PROTEINS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

OXY;

EID: 0034598349     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00588-0     Document Type: Article

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25. 4) and concentrated. The crude solid obtained was recrystallized in the solvent indicated.
26. + 558.1005, found 558.0946.
27. + 389.0807, found 389.0814.
28. + 387.0651, found 387.0709.
29. + 361.0494, found 361.0560.
30. + 411.0651, found 411.0704.
31. + 343.0236, found 343.0291.
32. + 385.0706, found 385.0715.
33. + 357.0393, found 357.0470.
34. + 385.0706, found 385.0684.
35. + 399.0862, found 399.0943.