New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 71-74

  Kennis, Ludo E J ^a   Bischoff, François P ^a   Mertens, Carolus J ^a   Love, Christopher J ^a   Van den Keybus, Frans A F ^a   Pieters, Serge ^a   Braeken, Mirielle ^a   Megens, Anton A H P ^a   Leysen, Josee E ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; ISOBENZOFURAN DERIVATIVE;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHO CELL; CONTROLLED STUDY; DEPRESSION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIDEPRESSIVE AGENTS; CHO CELLS; CLONIDINE; CRICETINAE; HUMANS; MALE; PRAZOSIN; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; XYLAZINE; YOHIMBINE;

ANIMALIA;

EID: 0034598318     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00591-0     Document Type: Article

References (22)

1. Ruffulo R. Jr., Nichols A., Stadel J., Hieble J.P. Pharmacol. Rev. 43:1991;475-505.
2. Limberger N., Spaeth L., Starke K. Br. J. Pharmacol. 103:1991;1251-1255.
3. Raiteri M., Bonanno G., Maura G., Pende M., Andrioli G.C., Ruelle A. Br. J. Pharmacol. 107:1992;1146-1151.
4. Telle S., Colpaert F., Marien M. J. Neurochem. 68:1997;1997.
5. Raiteri M., Maura G., Folghera S., Cavazzani P., Andrioli G.C., Schlicker E., Schalnus R., Goethert M. Naunyn-Smiedeberg's Arch. Pharmacol. 342:1990;508-512.
6. Tao R., Hjorth S. Naunyn-Smiedeberg's Arch. Pharmacol. 345:1992;137-143.
7. Maura G., Bonanno G., Raiteri M. Naunyn-Smiedeberg's Arch. Pharmacol. 345:1992;410-416.
8. Gresch P., Sved A., Zigmond M., Finlay J. J. Neurochem. 65:1995;111-116.
9. Grenhoff J., Svensson T. Eur. J. Pharmacol. 165:1989;11-18.
10. Richelson E., Pfenning M. Eur. J. Pharmacol. 104:1984;277-286.
11. Mitsui Petrochemical Industries Ltd. Japan. C.A. 118(19) 191334z; C.A. 106(5) 32536c.
12. Ple P., Marnett L.J. J. Heterocycl. Chem. 25:1988;1271-1272.
13. Titus R.L., Choi M., Hutt M.P. J. Heterocycl. Chem. 4:1967;651-652.
14. Graham S.L., Shepard K.L., Anderson P.S., Baldwin J.J., Best D.B., Christy M.E., Freedman M.B., Gautheron P., Habecker C.N. J. Med. Chem. 32:1989;2548-2554.
15. Barker P. Synth. Commun. 19:1989;257-265.
16. Wilk B.K. Synthetic Communications. 23(17):1993;2481-2484.
17. Wamhoff, H.; Korte, F. Synthesis 1972, 151-175
18. Leysen J., Niemegeers C., Van Nueten J., Laduron P. Mol. Pharmacol. 21:1982;301-304.
19. Oëstreicher E.G., Pinto G.F. Comptat. Biol. Med. 17:1987;53-68.
20. Megens A., Leysen J., Awouters F., Niemegeers C. Eur. J. Pharmacol. 129:1986;49-55.
21. Colpaert F. Drug Dev. Res. 7:1986;125-140.
22. Trendelenburg A.U., Limberger N., Starke K. J. Pharmacol. Exp. Ther. 278:1996;462-467.