The synthesis of streptogramin antibiotics: (-)-Griseoviridin and its C- 8 Epimer

Angewandte Chemie - International Edition

Volumn 39, Issue 9, 2000, Pages 1664-1666

  Dvorak, Curt A ^a   Schmitz, William D ^a   Poon, Daniel J ^a   Pryde, David C ^a   Lawson, Jon P ^a   Amos, Richard A ^a   Meyers, Albert I ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Antibiotics; Macrolides; Metathesis; Natural products; Total synthesis

Indexed keywords

GRISEOVIRIDIN; STREPTOGRAMIN DERIVATIVE; UNCLASSIFIED DRUG; VIRGINIAMYCIN;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY; STEREOISOMERISM;

EID: 0034595258     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000502)39:9<1664::AID-ANIE1664>3.0.CO;2-#     Document Type: Article

References (27)

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27. A sample of the heretofore unknown C-8 epi-griseoviridin has been submitted for antibacterial screening (Aventis) and found to be only very poorly active (courtesy of Dr. S. Dutka-Malen).