SCOPUS 정보 검색 플랫폼

Volumn 11, Issue 4, 2000, Pages 352-355

Determining synthetic failures in combinatorial libraries by hybrid gas-phase separation methods

Author keywords

[No Author keywords available]

Indexed keywords

IONIZATION; ISOMERS; MASS SPECTROMETERS; MASS SPECTROMETRY; MIXTURES; MOLECULAR STRUCTURE; SEPARATION;

COMBINATORIAL LIBRARIES;

SYNTHESIS (CHEMICAL);

PEPTIDE LIBRARY;

MASS SPECTROMETRY;

ARTICLE; GAS; IONIZATION; ISOMER; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PHASE SEPARATION; STANDARD;

CHROMATOGRAPHY, GAS; ISOMERISM; MASS SPECTROMETRY; PEPTIDE LIBRARY; PEPTIDES;

EID: 0034582601 PISSN: 10440305 EISSN: None Source Type: Journal
DOI: 10.1016/S1044-0305(00)00099-4 Document Type: Article

Times cited : (19)

References (17)

2
- 2142801217
- For discussions see: Chem. Eng. News 1996, February 12, p. 28; Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233-1251.

6
- 2142855239
- Ion mobility techniques are discussed in: Hagen, D. F. Anal Chem. 1979, 51, 870-874; Hill, H. H.; Siems, W. F.; St. Louis, R. H.; McMinn, D. G. Anal. Chem. 1990, 62, 1201A-1209A; von Helden, G.; Hsu, M.-T.; Kemper, P. R.; Bowers, M. T. J. Chem. Phys. 1991, 95, 3835-3837; Clemmer, D. E.; Jarrold, M. F. J. Mass Spectrom. 1997, 32, 577-592.

7
- 2142692351
- For discussions of binding affinities for mixtures see: Lam, K. S.; Salmon, S. E.; Hersh, E. M.; Hruby, V. J.; Kazmierski, W. M.; Knapp, R. J. Nature 1991, 354, 82-84; Salmon, S. E.; Lam, K. S.; Lebl, M.; Kandola, A.; Khattri, P. S.; Wade, S.; Patek, M.; Kocis, P.; Krchnak, V.; Thrope, D.; Felder, S. Proc. Natl. Acad. Sci. USA 1993, 90, 11708-11712; Jayawickreme, C. K.; Graminski, G. E.; Quillan, J. M.; Lerner, M. R. Proc. Natl. Acad. Sci. USA 1994, 91, 1614-1618.

8
- 2142687762
- Mix and split strategies have been described previously. See, for example: Lebl, M.; Krchnak, V. Methods Enzymol. 1997, 289, 336-392.

11
- 2142805355
- Hoaglund, C. S.; Valentine, S. J.; Sporleder, C. R.; Reilly, J. P.; Clemmer, D. E. Anal. Chem. 1998, 70, 2236-2242; Henderson, S. C.; Valentine, S. J.; Counterman, A. E.; Clemmer, D. E. Anal. Chem. 1999, 71, 291-301.

12
- 2142860370
- The value of 300 unique molecular weights comes from considering that of the 26 variable residues 24 have unique masses. Thus, there will be (24 + 2 - 1)!/2!(24 - 1)! = 300 unique peptide masses. For a discussion of combinatorial statistics see: Demirev, P. A.; Zubarev, R. A. Anal. Chem. 1997, 69, 2893-2900.

13
- 2142799689
- TIC peptides could be absent because they are preferentially formed as doubly protonated ions; examination of the mass spectrum indicates that this is not the case.

14
- 2142852707
- Ion conformers were generated using the Insight II software; BIOSYM/MSI: San Diego, CA, 1995. A multistage simulated annealing procedure was used. See: Counterman, A. E.; Clemmer, D. E. J. Am. Chem. Soc. 1999, 121, 4031-4039.

15
- 2142855238
- von Helden, G.; Hsu, M.-T.; Gotts, N.; Bowers, M. T. J. Phys. Chem. 1993, 97, 8182-8192; Mesleh, M. F.; Hunter, J. M.; Shvartsburg, A. A.; Schatz, G. C.; Jarrold, M. F. J. Phys. Chem. 1996, 100, 16082-16086; Shvartsburg, A. A.; Schatz, G. C.; Jarrold, M. F. J. Chem. Phys. 1998, 108, 2416-2423.

16
- 2142802255
- Details of peptide synthesis can be found in: Bodanszky, M. Principles of Peptide Synthesis, 2nd ed.; Springer: Berlin, 1993; Bodanszky, M. Peptide Chemistry, A Practical Textbook, 2nd ed.; Springer: Berlin, 1993.

17
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- Samuelson, S. O.; Martyna, G. J. J. Phys. Chem. 1998, 109, 11061-11073; Hoaglund-Hyzer, C. S.; Counterman, A. E.; Clemmer, D. E. Chem. Rev. 1999, 99, 3037-3080.

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