Autoregulation of neurotransmitter release at autonomic nerve terminals: A questionable theory

Journal of Autonomic Pharmacology

Volumn 20, Issue 5-6, 2000, Pages 271-279

  Kalsner, S ^a  

^a CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; AUTORECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; NEUROTRANSMITTER; NORADRENALIN; PHENOXYBENZAMINE; PRESYNAPTIC RECEPTOR; RECEPTOR BLOCKING AGENT; YOHIMBINE;

AUTONOMIC NERVE; AUTONOMIC NERVOUS SYSTEM; AUTOREGULATION; DRUG EFFECT; DRUG MECHANISM; FEEDBACK SYSTEM; HUMAN; HYPOTHESIS; INHIBITION KINETICS; NEGATIVE FEEDBACK; NERVE ENDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC NERVE; REGULATORY MECHANISM; REVIEW; SYSTEM ANALYSIS;

ANIMALS; AUTONOMIC PATHWAYS; AUTORECEPTORS; FEEDBACK; HOMEOSTASIS; HUMANS; NERVE ENDINGS; NEUROTRANSMITTER AGENTS;

EID: 0034581642     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2680.2000.00191.x     Document Type: Review

References (65)

1. 3H-noradrenaline release from rabbit isolated aorta
2. Role of autoinhibitory feedback in cardiac sympathetic transmission
3. Drug receptor interaction: Interaction of one or more drugs with one receptor system
4. Presynaptic alpha-adrenoceptors: Do exogenous and neuronally released noradrenaline act at different sites
5. Release of endogenous noradrenaline from an isolated muscular artery
6. The packeted release of sympathin from single release sites in the rodent vas deferens. Is release subject to feedback control?
7. Facilitation at single release sites of a sympathetic neuroeffector junction in the mouse
8. The output of sympathetic transmitter from the spleen of the cat
9. An examination of the negative feedback function of presynaptic adrenoceptors in a vascular tissue
10. Local modulation of neurotransmitter release in bovine splenic vein
11. 3H-noradrenaline release and mechanical response in the field stimulated mouse vas deferens
12. The effects of morphine on the release of noradrenaline from the cat isolated nicitating membrane and the guinea-pig ileum myenteric plexus-longitudinal muscle preparation
13. An electrophysiological analysis of the effects of noradrenaline and x-receptor antagonists on neuromuscular transmission in mammalian muscular arteries
14. Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens
15. Prejunctional adrenergic receptors and sympathetic neurotransmission: Studies in canine skeletal muscle vasculature in situ
16. Adrenergic presynaptic receptors: Examination of a hypothesis in guinea pig vas deferens
17. Single pulse stimulation of guinea pig vas deferens and the presynaptic receptor hypothesis
18. Adrenergic presynaptic receptors: An overextended hypothesis?
19. 3H]noradrenaline in vas deferens
20. The role of calcium in the effects of noradrenaline and phenoxybenzamine on adrenergic transmitter release from atria: No support for negative feedback of release
21. Evidence against the unitary hypothesis of agonist and antagonist action at presynaptic adrenoceptors
22. 3H-transmitter efflux in heart: An alternative to the negative feedback hypothesis
23. Evidence that transmitter release in sympathetic nerves is not set by feedback via presynaptic receptors
24. Limitations of presynaptic theory: No support for feedback control of autonomic effectors
25. Is there feedback regulation of neurotransmitter release by autoreceptors?
26. Clonidine and presynaptic adrenoceptor theory
27. Heteroreceptors, autoreceptors, and other terminal sites
28. Presynaptic receptors and autonomic effectors
29. The problem with autoreceptors
30. Adrenergic presynaptic antagonists and their mechanism of action in smooth muscle
31. The question of feedback at the somadendritic region and antidepressant drug action
32. 3H]noradrenaline in renal arteries: Limitations of the unitary hypothesis of presynaptic regulation of transmitter release
33. Interactions between acetylcholine and adrenergic presynaptic antagonists on norepinephrine release
34. Effects of cocaine, phenoxybenzamine and phentolamine on the catecholamine output from spleen and adrenal medulla
35. Characterization of the clonidine receptor site
36. Modulation of neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea-pig mesenteric artery
37. Presynaptic regulation of the release of catecholamines
38. Prejunctional regulatory mechanisms for nor-adrenaline release elicted by nerve stimulation
39. Lack of feedback via presynaptic -adrenoceptors by noradrenaline released by a single pulse
40. 2-adrenoceptors
41. Calcium currents modulated by adrenergic receptors in sympathetic neurones
42. Effects of phenoxybenzamine and norepinephrine on transmitter release in the pulmonary artery of the rabbit
43. 3H-noradrenaline release from rabbit pulmonary artery: Effect of -adrenoceptor antagonists and inhibitors of transmitter inactivation
44. Feedback modulation of noradrenergic transmission
45. Interactions of neuronal systems at presynaptic receptors based upon in vitro and In vivo studies - Focus on serotonergic neuronal systems
46. Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: Evidence for an - Receptor-mediated feed-back inhibition of noradrenaline release
47. Regulation of noradrenaline release by presynaptic receptor systems
48. Presynaptic -autoreceptors
49. Presynaptic receptors that regulate neurotransmitter release
50. Relative pre and postsynaptic potencies of -adrenoceptor agonists in the rabbit pulmonary artery
51. Modulation of neurotransmitter release by presynaptic autoreceptors
52. Comparison of the effects of clonidine on pre and postsynaptic adrenoceptors in the rabbit pulmonary artery
53. On sites and mechanisms of presynaptic control of noradrenaline secretion
54. Scope and mechanisms of control of stimulus secretion coupling in single varicosities of sympathetic nerve
55. Conditions for the operation of presynaptic receptors
56. Adrenergic transmission in the dog mesenteric vein and its modulation by -adrenoceptor antagonists
57. Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system
58. Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission
59. General views on the relevance of presynaptic receptor systems
60. Release of noradrenalin by one pulse: Modulation of such release by alpha-adrenoceptor antagonists and uptake blockers
61. Local regulation of adrenergic neurotransmission
62. The physiological operation of presynaptic inhibitory autoreceptors
63. A new method for simultaneous measurement of endogenous noradrenaline release and vascular responsiveness in perfused rabbit carotid arteries in vitro