Tumor blood supply and tumor localization by adoptively transferred IL-2 activated natural killer cells

In Vivo

Volumn 14, Issue 5, 2000, Pages 651-658

  Nannmark, Ulf ^a   Hokland, Marianne E ^a   Agger, Ralf ^a   Christiansen, Mads ^a   Kjaergaard, Jørgen ^a   Goldfarb, Ronald H ^a   Bagge, Ulf ^a   Unger, Martin ^a   Johansson, Bengt R ^a   Albertsson, Per A ^a   Basse, Per H ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Adoptive immunotherapy; Cell traffic lymphocyte homing; Experimental metastases; Natural Killer (NK) cells; Tumor blood supply

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER SIZE; CELL DENSITY; CELL KINETICS; CELL TRANSFER; CONTROLLED STUDY; LUNG METASTASIS; LUNG PARENCHYMA; MELANOMA B16; MICROCIRCULATION; MICROSCOPY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL CIRCULATION; SUBCUTANEOUS TISSUE; TUMOR LOCALIZATION; TUMOR VASCULARIZATION;

EID: 0034579744     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Successful immunotherapy of natural killer-resistant established pulmonary melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2
2. Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2
3. Enhanced antimetastatic activity of lymphokine-activated killer cells purified and expanded by their adherence to plastic
4. Rapid Il-2-induced adherence of human natural killer cells. Expression of mRNA for cytokines and IL-2 receptors in adherent NK cells
5. Approaches to immunotherapy with defined populations of IL-2 cultured NK cells, immune T cells or tumor infiltrating lymphocytes
6. Accumulation of adoptively transferred adherent, lymphokine-activated killer cells in murine metastases
7. Accumulation of adoptively transferred A-NK cells in murine metastases: Kinetics and role of interleukin-2
8. Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice
9. Establishment of cell-to-cell contact by adoptively transferred adherent lymphokine-activated killer cells with metastatic murine melanoma cells
10. Microvessel origin and distribution in pulmonary metastases of B16 melanoma: Implication for adoptive immunotherapy
11. Induction of tumor regression in experimental model of human head and neck cancer by human A-LAK cells and IL-2
12. Expression and function of LFA-1 on A-NK and T-LAK cells: Role in tumor target killing and migration into tumor tissue
13. Intratumoral proliferation of the blood vessels
14. Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension
15. Circadian variation of tumor blood flow in rat subcutaneous tumors and its alteration by angiotensin II-induced hypertension
16. Retention of adoptively transferred interleukin-2-activated natural killer cells in tumor tissue
17. Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution
18. Surface characteristics, morphology, and ultrastructure of human adherent lymphokine-activated killer cells
19. Migration of IL-2-activated natural killer cells in vitro: Influence of extracellular matrix proteins
20. Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells
21. Physiologically based kinetic model of effector cell biodistribution in mammals: Implications for adoptive immunotherapy