Plaque Regrowth Effects of a Triclosan/Pyrophosphate Dentifrice in a 4-Day Non-Brushing Model

Journal of Clinical Dentistry

Volumn 11, Issue 4, 2000, Pages 107-113

  McClanahan, Stephen F ^a   Bollmer, Bernard W ^a   Court, Linda K ^a   McClary, John M ^a   Majeti, S ^a   Crisanti, Mark M ^a   Beiswanger, Bradley B ^b   Mau, Melissa S ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CREST REGULAR DENTIFRICE; DRUG VEHICLE; FLUORIDE SODIUM; PYROPHOSPHATE; SILICON DIOXIDE; TOOTHPASTE; TRICLOSAN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; TOOTH PLAQUE; VEHICLES;

ADULT; ANTI-INFECTIVE AGENTS; CROSS-OVER STUDIES; DENTAL PLAQUE; DENTAL PLAQUE INDEX; DENTIFRICES; DIPHOSPHATES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; RECURRENCE; SILICON DIOXIDE; SODIUM FLUORIDE; TRICLOSAN; VEHICLES;

EID: 0034577327     PISSN: 08958831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Regos J, Zak O, Solf R, Vischer WA, Weirich EG: Antimicrobial spectrum of triclosan, a broad-spectrum antimicrobial agent for topical application. II. Comparison with some other antimicrobial agents. Dermatologica 158:72-79, 1979.
2. Nabi N, Mukerjee, C, Schmid R, Gaffar A: In vitro and in vivo studies on triclosan/PVM/MA copolymer/NaF combination as an anti-plaque agent. Am J Dent 2:197-206, 1989.
3. Savage CA: A new bacteriostat for skin care products. Drug Cosmet Ind 109: 136-163, 1971.
4. Meincke BE, Kranz RG, Lynch DL: Effect of irgasan on bacterial growth and its adsorption into the cell wall. Microbios 28:133-147, 1980.
5. Lane RM, Hull DMC, Saxton CA, van der Oudera FJG: Dentifrice compositions, US Patent 4656031, Issued April 7, 1987.
6. Lee C-J: Development and Evaluation of Drugs. CRC Press, Boca Raton, FL, pp. 153-181, 1993.
7. Addy M, Willis L, Moran J: Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol 10:89-99, 1983.
8. Williams MJR, Adams D, Hillam DG, Ashley KC: The effect of hexetidine 0.1% in the control of dental plaque. Br Dent J 163:300-302, 1987.
9. Renton-Harper P, Addy M, Moran J, Doherty FM, Newcombe RG: A comparison of chlorhexidine, cetylpyridinium chloride, triclosan, and C31G mouthrinse products for plaque inhibition. J Periodontol 67:486-489, 1996.
10. Jenkins S, Addy M, Newcombe RJ: A dose-response study of triclosan mouthrinses on plaque regrowth. J Clin Periodontol 20:609-612, 1993.
11. Moran J, Addy M, Newcombe R: A 4-day plaque regrowth study comparing an essential oil mouthrinse with a triclosan mouthrinse. J Clin Periodontol 24:636-639, 1997.
12. Addy M, Jenkins S, Newcombe R: The effects of triclosan, stannous fluoride and chlorhexidine products on: (I) Plaque regrowth over a 4-day period. J Clin Periodontol 17:693-697, 1990.
13. Jenkins S, Addy M, Newcombe RG: Dose response of chlorhexidine against plaque and comparison with triclosan. J Clin Periodontol 21:250-255, 1994.
14. Jenkins S, Addy M, Newcombe R: Triclosan and sodium lauryl sulphate mouthrinses. (II). Effects of 4-day plaque regrowth. J Clin Periodontol 18: 145-148, 1991.
15. Jenkins S, Addy M, Newcombe R: Studies on the effect of toothpaste rinses on plaque regrowth. (II). Triclosan with and without zinc citrate formulations. J Clin Periodontol 16:385-387, 1989.
16. Binney A, Addy M, Owens J, Faulkner J: A comparison of triclosan and stannous fluoride toothpastes for inhibition of plaque regrowth. A crossover study designed to assess carry over. J Clin Periodontol 24:166-170, 1997.
17. Riep BG, Bernimoulin J-P, Barnett ML: Comparative antiplaque effectiveness of an essential oil and an amine fluoride/stannous fluoride mouthrinse. J Clin Periodontol 26:164-168, 1999.
18. Jenkins S, Addy M, Newcombe RG: A comparison of cetylpyridinium chloride, triclosan and chlorhexidine mouthrinse formulations for effects on plaque regrowth. J Clin Periodontol 21:441-444, 1994.
19. Saxton CA: The effects of a dentifrice containing zinc citrate and 2,4,4′ trichloro-2′-hydroxydiphenyl ether. J Periodontol 57:555-561, 1986.
20. Binney A, Addy M, McKeown S, Everatt L: The effect of a commercially available triclosan-containing toothpaste compared to a sodium fluoride-containing toothpaste and a chlorhexidine rinse on 4-day plaque regrowth. J Clin Periodontol 22:830-834, 1995.
21. Binney A, Addy M, McKeown S, Everatt L: The choice of controls in toothpaste studies. The effect of a number of commercially available toothpastes compared to water on 4-day plaque regrowth. J Clin Periodontol 23:456-459, 1996.
22. Moran J, Addy M, Roberts S: A comparison of natural product, triclosan and chlorhexidine mouthrinses on 4-day plaque regrowth. J Clin Periodontol 19: 578-582, 1992.
23. Mendieta C, Vallcorba N, Binney A, Addy M: Comparison of 2 chlorhexidine mouthwashes on plaque regrowth in vivo and dietary staining in vitro. J Clin Periodontol 21:296-300, 1994.
24. Moran J, Addy M, Wade W, Milson S, McAndrew R, Newcombe RG: The effect of oxidizing mouthrinses compared with chlorhexidine on salivary bacterial counts and plaque regrowth. J Clin Periodontol 22:750-755, 1995.
25. Moran J, Addy M, Wade WG, Maynard JH, Roberts SE, Astrom M, Movert R: A comparison of delmopinol and chlorhexidine on plaque regrowth over a 4-day period and salivary bacterial counts. J Clin Periodontol 19:749-753, 1992.
26. Moran J, Addy M, Jackson R, Newcombe RG: Comparative effects of quaternary ammonium mouthrinses on 4-day plaque regrowth. J Clin Periodontol 27:37-40, 2000.
27. Yates R, Moran J, Addy M, Mullan PJ, Wade WG, Newcombe R: The comparative effect of acidified sodium chlorite and chlorhexidine mouthrinses on plaque regrowth and salivary bacterial counts. J Clin Periodontol 24:603-609, 1997.
28. Binney A, Addy M, Newcombe RG: The effect of a number of commercial mouthrinses compared with toothpaste on plaque regrowth. J Periodontol 63: 839-842, 1992.
29. Moran J, Addy M, Kohut B, Hovliaras CA, Newcombe RG: Efficacy of mouthrinses in inhibiting the development of supragingival plaque over a 4-day period of no oral hygiene. J Periodontol 65:904-907, 1994.
30. Saxton CA, Lane RM, van der Ouderaa F: The effects of a dentifrice containing a zinc salt and a non-cationic antimicrobial agent on plaque and gingivitis. J Clin Periodontol 14:144-148, 1987.
31. Jenkins S, Addy M, Newcombe R: Toothpastes containing 0.3% and 0.5% triclosan. I. Effects on 4-day plaque regrowth. Am J Dent 2:211-214, 1989.
32. Silness J, Löe H: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odont Scand 22:121-135, 1964.
33. Wade WG, Addy M: Antibacterial activity of some triclosan-containing toothpastes and their ingredients. J Periodontal 63:280-282, 1992.
34. Data on file. The Procter & Gamble Company, Cincinnati, OH.